Results 21 to 30 of about 22,951 (177)
Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe. [PDF]
PLoS ONE, 2015 The activity of Cdc2 (CDK1) kinase, which coordinates cell cycle progression and DNA break repair, is blocked upon its phosphorylation at tyrosine 15 (Y15) by Wee1 kinase in the presence of DNA damage.
Thomas Caspari, Victoria Hilditch
doaj +1 more source
BMC Cancer, 2008 Background Gliomas are the most common and aggressive primary brain tumors for which unfortunately no effective treatment modalities exist despite advances in molecular biology as the knowledge base to unravel the extremely complex molecular mechanisms ...
Wang Ai-Dong +5 more
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Nature Communications, 2021 Type 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear.
Nikos E. Papaioannou +22 more
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Cell Reports, 2023 Summary: The current paradigm indicates that naive T cells are primed in secondary lymphoid organs. Here, we present evidence that intranasal administration of peptide antigens appended to nanofibers primes naive CD8+ T cells in the lung independently ...
Youhui Si +9 more
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Are physiological oscillations physiological?
The Journal of Physiology, EarlyView., 2023 Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley +1 more source
Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression. [PDF]
Proceedings of the National Academy of Sciences, 1992 Recent studies have shown that there exists a family of protein kinases structurally and functionally related to the yeast cell cycle regulatory kinase cdc2 [Meyerson, M., Faha, B., Su, L.-K., Harlow, E. & Tsai, L.-H. (1991) Cold Spring Harbor Symp. Quant. Biol. 56, 177-186 and Meyerson, M., Enders, G. H., Wu, C.-L., Su, L.-K., Gorka, C., Nelson, C.
M R, Hellmich +3 more
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Biomedicines, 2022 Inflammatory bowel disease (IBD) is an idiopathic and chronic disorder that includes ulcerative colitis (UC) and Crohn’s disease (CD). Both diseases show an uncontrolled intestinal immune response that generates tissue inflammation. Dendritic cells (DCs)
Irene Soleto +13 more
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ILC2‐derived IL‐13 promotes skin cDC2 diversity [PDF]
Immunology & Cell Biology, 2021 In a new study, researchers have identified a new population of type 2 conventional dendritic cells in the skin that depend on IL-13 and promote Th2 mediated immunity.
Stephen L Nutt, Michaël Chopin
openaire +3 more sources
GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2
Frontiers in Immunology, 2023 Conventional type 1 dendritic cells (cDC1) and conventional type 2 dendritic cells (cDC2) have attracted increasing attention as alternatives to monocyte-derived dendritic cells (moDCs) in cancer immunotherapy.
Seyed Mohammad Lellahi +14 more
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Cell Cycle Sibling Rivalry: Cdc2 Versus Cdk2 [PDF]
Cell Cycle, 2005 It has been long believed that the cyclin-dependent kinase 2 (Cdk2) binds to cyclin E or cyclin A and exclusively promotes the G1/S phase transition and that Cdc2/cyclin B complexes play a major role in mitosis. We now provide evidence that Cdc2 binds to cyclin E (in addition to cyclin A and B) and is able to promote the G1/S transition.
Philipp, Kaldis, Eiman, Aleem
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