Results 31 to 40 of about 22,951 (177)

Intestinal CD103+CD11b+ cDC2 Conventional Dendritic Cells Are Required for Primary CD4+ T and B Cell Responses to Soluble Flagellin

Frontiers in Immunology, 2018
Systemic immunization with soluble flagellin (sFliC) from Salmonella Typhimurium induces mucosal responses, offering potential as an adjuvant platform for vaccines. Moreover, this engagement of mucosal immunity is necessary for optimal systemic immunity,
Adriana Flores-Langarica, Charlotte Cook, Katarzyna Müller Luda, Emma K. Persson, Jennifer L. Marshall, Nonantzin Beristain-Covarrubias, Juan Carlos Yam-Puc, Madelene Dahlgren, Jenny J. Persson, Satoshi Uematsu, Satoshi Uematsu, Shizuo Akira, Ian R. Henderson, Bengt Johansson Lindbom, Bengt Johansson Lindbom, William Agace, William Agace, Adam F. Cunningham   +17 more
doaj   +1 more source

CD163+ cytokine-producing cDC2 stimulate intratumoral type 1 T cell responses in HPV16-induced oropharyngeal cancer

Journal for ImmunoTherapy of Cancer, 2020
Background Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a distinct clinical entity with a much better prognosis after (chemo)radiotherapy than HPV-negative OPSCC, especially in patients with a concomitant ...
Sjoerd H van der Burg, Ilina Ehsan, Ekaterina J Jordanova, Florent Ginhoux, Saskia J Santegoets, Chantal L Duurland, Nikki M Loof, Sylvia L van Egmond, Vanessa J van Ham, Vipin Narang, Charles A Dutertre, Marij J P Welters   +11 more
doaj   +1 more source

Carboxyl-terminal Domain of p27Kip1 Activates CDC2 [PDF]

Journal of Biological Chemistry, 1997
A variant form of p27 was unexpectedly detected in a synchronized culture of NIH3T3 cells treated with serum. The expression levels of this form of p27 which lacked its amino (NH2)-terminal region reached maximum during G2/M phase. Since the appearance of the NH2-terminal truncated form of p27 coincided with increased expression of Cdc2, we ...
Uren A, Jakus J, Font de Mora J, Yeudall A, Santos E, Gutkind S, Heidaran MA   +6 more
openaire   +3 more sources

Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition – implications for the next generation of DC vaccines

OncoImmunology, 2019
Current treatments for glioblastoma (GBM) have limited efficacy and significant morbidity and therefore new strategies are urgently needed. Dendritic cells have the power to create anti-tumor immune responses. The greater potency of circulating dendritic
Jason Adhikaree, Hester Ann Franks, Constantinos Televantos, Poonam Vaghela, Aanchal Preet Kaur, David Walker, Marc Schmitz, Andrew Mark Jackson, Poulam Manubhai Patel   +8 more
doaj   +1 more source

Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

eLife, 2020
Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response to vaccination, producing long-lived antibody secreting plasma cells and memory B cells that protect against subsequent infection. With advancing age the
Marisa Stebegg, Alexandre Bignon, Danika Lea Hill, Alyssa Silva-Cayetano, Christel Krueger, Ine Vanderleyden, Silvia Innocentin, Louis Boon, Jiong Wang, Martin S Zand, James Dooley, Jonathan Clark, Adrian Liston, Edward Carr, Michelle A Linterman   +14 more
doaj   +1 more source

Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase. [PDF]

The EMBO Journal, 1992
Exit from metaphase of the cell cycle requires inactivation of MPF, a stoichiometric complex between the cdc2 catalytic and the cyclin B regulatory subunits, as well as that of cyclin A-cdc2 kinase. Inactivation of both complexes depends on proteolytic degradation of the cyclin subunit, yet cyclin proteolysis is not sufficient to inactivate the H1 ...
T, Lorca, J C, Labbé, A, Devault, D, Fesquet, J P, Capony, J C, Cavadore, F, Le Bouffant, M, Dorée   +7 more
openaire   +2 more sources

Characterization of the Murine cdc2 Gene

Molecules and Cells, 1998
A 1204 bp full-length cDNA encoding murine cdc2 was isolated and used as a probe to obtain four overlapping cdc2 genomic clones which span the entire cdc2 sequence. Characterization of these clones revealed that the cdc2 mRNA is distributed over 28 kb and in 8 exons ranging in size from 63 to approximately 303 bp.
D, Jun, H K, Park, A A, Nordin, J E, Nagel, Y H, Kim   +4 more
openaire   +2 more sources

Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway

Virology Journal, 2018
Porcine reproductive and respiratory syndrome virus(PRRSV) is an important immunosuppressive virus which can suppresses infected cells proliferation.
Linlin Song, Ximeng Han, Cunyu Jia, Xin Zhang, Yunjie Jiao, Taofeng Du, Shuqi Xiao, Julian A. Hiscox, En-Min Zhou, Yang Mu   +9 more
doaj   +1 more source

Cdc2: a monopotent or pluripotent CDK? [PDF]

Cell proliferation, 2011
Cell cycle progression is controlled by both extracellular and intracellular signalling molecules. It has been generally believed that cdc2/CDK1 only control G(2)-M transition in mammalian and many other higher eukaryotic cells. Accumulating evidence shows that cdc2 not only promotes G(2)-M transition but is also capable of regulating G(1) progress and
X, Hu, L C, Moscinski
openaire   +2 more sources

S100A8/A9 (calprotectin) negatively regulates G2/M cell cycle progression and growth of squamous cell carcinoma. [PDF]

PLoS ONE, 2013
Malignant transformation results in abnormal cell cycle regulation and uncontrolled growth in head and neck squamous cell carcinoma (HNSCC) and other cancers.
Ali Khammanivong, Chengxing Wang, Brent S Sorenson, Karen F Ross, Mark C Herzberg   +4 more
doaj   +1 more source