Results 61 to 70 of about 29,622 (230)

Mapping Allergen B‐ and T‐Cell Epitopes: Technological Advances and Their Role in Precision Allergy Therapy

Allergy, EarlyView.
ABSTRACT Allergic diseases arise from aberrant immune recognition of otherwise harmless environmental proteins and are driven by epitope‐specific interactions between allergens and the adaptive immune system. Although component‐resolved diagnostics have improved molecular characterisation of sensitization, they remain limited to whole‐allergen ...
Mark Møiniche, Josefine Corneliussen, Kristoffer H. Johansen, Alexandre Ruiz‐Carrasco, Caroline Paulsen, Yuchen Li, Carolina Barra, Sandhya Bangaru, Monica L. Fernández‐Quintero, Ewa Bartko, Lars Blom, Esperanza Rivera‐de‐Torre   +11 more
wiley   +1 more source

Only Cdc2-He and Cdc2-Hf are phosphorylated at tyrosine 15.

, 2015
(A) Serial dilutions (10-fold; starting with 107 cells/ml) of the listed strains were spotted onto YEA plates containing the indicated drugs. The plates were incubated at 30°C for 3 days. One YEA plate was incubated at 37°C.
Victoria Hilditch (763611), Thomas Caspari (155113)   +1 more
core   +1 more source

Discovery of triterpenoid derivatives as novel selective CDC2-like kinase 2 inhibitors against knee osteoarthritis

Journal of Chemical Research
CDC2-like kinase 2 is a promising target for the therapy of knee osteoarthritis. A series of natural and commercial triterpenoid derivatives were evaluated for their inhibitory activity against CDC2-like kinase 2 using ADP-Glo assay by GloMax ® Navigator
Xiaozhe Zhang, Kesong Shi, Tao Zhang, Qingpu Wang   +3 more
doaj   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer

, 2021
Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity of splice factors and of ...
B Clark (11242545), SR Porazinski (21887372), MR Ladomery (21887381), S Uzor (21929222), K Iida (21929228), ID Wilson (21831332), M Hagiwara (21929231), CM Perks (7223), L Li (4699549), M Ajiro (21929225), AA Alqasem (21929234), S Oltean (21860669)   +11 more
core   +1 more source

Cxbladder Triage in Haematuria Assessment Reduces Time From Referral to Specialist Assessment and Bladder Cancer Treatment and Improves Equity for Māori

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Bladder cancer is responsible for considerable morbidity and mortality. Patients commonly present with haematuria to primary care for assessment. In Canterbury, New Zealand, the first‐line investigations available to primary care were changed in 2018, from urine cytology to CxBladder Triage (CxBT) and upper urinary tract imaging ...
Daniel Eaton, Melissa Kerdemelidis, Giovanni Losco, Stephen Mark, Maira Patu, Nikki Elliot, Chris Frampton   +6 more
wiley   +1 more source

CXCR5 Signals Fine-Tune Dendritic Cell Transcription and Regulate T_H2 Development

Vaccines
Background/Objectives: We previously demonstrated that dendritic cell (DC) expression of CXCR5 is required for TH2 priming in mice infected with the helminth Heligmosomoides polygyrus (Hp).
Miranda L. Curtiss, Natalia Ballesteros Benavides, Alexander F. Rosenberg, Christopher D. Scharer, Beatriz León, Frances E. Lund   +5 more
doaj   +1 more source

Phosphorylation of numatrin and other nuclear proteins by cdc2 containing CTD kinase cdc2/p58

Journal of Biological Chemistry, 1991
Numatrin is a nuclear matrix phosphoprotein whose synthesis and abundance were shown to be regulated during the cell cycle in mitogen-stimulated lymphocytes (Feuerstein, N., and Mond, J. (1987) J. Biol. Chem. 262, 11389-11397). We examined the effect of (a) CTD-kinase, which contains the cdc2 catalytic component (p34) in a complex with a p58 subunit ...
openaire   +2 more sources

Carboxyl-terminal Domain of p27Kip1 Activates CDC2 [PDF]

Journal of Biological Chemistry, 1997
A variant form of p27 was unexpectedly detected in a synchronized culture of NIH3T3 cells treated with serum. The expression levels of this form of p27 which lacked its amino (NH2)-terminal region reached maximum during G2/M phase. Since the appearance of the NH2-terminal truncated form of p27 coincided with increased expression of Cdc2, we ...
Uren A, Jakus J, Font de Mora J, Yeudall A, Santos E, Gutkind S, Heidaran MA   +6 more
openaire   +3 more sources

scRNA‐Seq in Gastric Cancer Reveals Macrophage‐Derived C1q as a Diagnostic Marker

Cancer Science, EarlyView.
Single‐cell sequencing of GC analyzed the tumor microenvironment and discovered the C1QA+ TAMs subpopulation with immunosuppressive function. The role of C1q in the prognosis and diagnosis of GC was demonstrated through plasma and tumor tissue from the GC cohort.
Saisai Gong, Yupeng Zhao, Sheng Yang, Tong Liu, Chengyun Li, Yun Zhou, Geyu Liang   +6 more
wiley   +1 more source