Results 61 to 70 of about 29,264 (228)

Dynamic recruitment of Cdc2 to specific microtubule structures during mitosis [PDF]

, 2001
A-type cyclin-dependent kinases (CDKs), also known as cdc2, are central to the orderly progression of the cell cycle. We made a functional Green Fluorescent Protein (GFP) fusion with CDK-A (Cdc2-GFP) and followed its subcellular localization during the ...
Binarova, P., Heberle-Bors, E., Bogre, L., Doonan, J., David, J. P., Drykova, D., Weingartner, M., Schweighofer, A.   +7 more
core  

Discovery of triterpenoid derivatives as novel selective CDC2-like kinase 2 inhibitors against knee osteoarthritis

Journal of Chemical Research
CDC2-like kinase 2 is a promising target for the therapy of knee osteoarthritis. A series of natural and commercial triterpenoid derivatives were evaluated for their inhibitory activity against CDC2-like kinase 2 using ADP-Glo assay by GloMax ® Navigator
Xiaozhe Zhang, Kesong Shi, Tao Zhang, Qingpu Wang   +3 more
doaj   +1 more source

Identification of dendritic cell precursor from the CD11c+ cells expressing high levels of MHC class II molecules in the culture of bone marrow with FLT3 ligand

Frontiers in Immunology, 2023
Dendritic cells (DCs) are readily generated from the culture of mouse bone marrow (BM) treated with either granulocyte macrophage-colony stimulating factor (GM-CSF) or FMS-like tyrosine kinase 3 ligand (FLT3L).
Hyunju In, Hyunju In, Ji Soo Park, Ji Soo Park, Hyun Soo Shin, Hyun Soo Shin, Seul Hye Ryu, Seul Hye Ryu, Seul Hye Ryu, Moah Sohn, Moah Sohn, Wanho Choi, Wanho Choi, Sejung Park, Sejung Park, Soomin Hwang, Soomin Hwang, Jeyun Park, Lihua Che, Lihua Che, Tae-Gyun Kim, Min Kyung Chu, Hye Young Na, Hye Young Na, Chae Gyu Park, Chae Gyu Park, Chae Gyu Park   +26 more
doaj   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Proto‐Panic Modulation by Caffeine‐Proteinoid Complexes

Journal of Applied Polymer Science, EarlyView.
Caffeine–proteinoid microspheres synthesized by thermal polymerization exhibit compartmentalized drug loading with encapsulation efficiencies of 61%–82% and triphasic release kinetics. Electrochemical monitoring reveals multi‐scale oscillatory dynamics consistent with chaotic and damped harmonic behavior, while Boolean logic operations demonstrate ...
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

CXCR5 Signals Fine-Tune Dendritic Cell Transcription and Regulate T_H2 Development

Vaccines
Background/Objectives: We previously demonstrated that dendritic cell (DC) expression of CXCR5 is required for TH2 priming in mice infected with the helminth Heligmosomoides polygyrus (Hp).
Miranda L. Curtiss, Natalia Ballesteros Benavides, Alexander F. Rosenberg, Christopher D. Scharer, Beatriz León, Frances E. Lund   +5 more
doaj   +1 more source

Phosphorylation of numatrin and other nuclear proteins by cdc2 containing CTD kinase cdc2/p58

Journal of Biological Chemistry, 1991
Numatrin is a nuclear matrix phosphoprotein whose synthesis and abundance were shown to be regulated during the cell cycle in mitogen-stimulated lymphocytes (Feuerstein, N., and Mond, J. (1987) J. Biol. Chem. 262, 11389-11397). We examined the effect of (a) CTD-kinase, which contains the cdc2 catalytic component (p34) in a complex with a p58 subunit ...
openaire   +2 more sources

Carboxyl-terminal Domain of p27Kip1 Activates CDC2 [PDF]

Journal of Biological Chemistry, 1997
A variant form of p27 was unexpectedly detected in a synchronized culture of NIH3T3 cells treated with serum. The expression levels of this form of p27 which lacked its amino (NH2)-terminal region reached maximum during G2/M phase. Since the appearance of the NH2-terminal truncated form of p27 coincided with increased expression of Cdc2, we ...
Uren A, Jakus J, Font de Mora J, Yeudall A, Santos E, Gutkind S, Heidaran MA   +6 more
openaire   +3 more sources

High‐Dimensional Spectral Flow Cytometry Panel for Immunophenotypic Characterization of Fixed Whole Blood Samples

Cytometry Part A, EarlyView.
ABSTRACT Peripheral blood mononuclear cells (PBMCs) are commonly used for immune profiling in clinical research, but their isolation and cryopreservation present logistical challenges, particularly in settings with limited access to research facilities. To address this, we implemented a whole blood fixation protocol to preserve surface protein epitopes
Vaishnavi Parthasarathy, Alexander T. Heubeck, Tyanna Stuckey, Veronica Hernandez, Blessing Musgrove, Maia M. Bennett‐Boehm, Troy Torgerson, Peter Skene, Julian Reading   +8 more
wiley   +1 more source

Activation of type-1 protein phosphatase by cdc2 kinase [PDF]

, 1992
Purified cdc2 or cdc2 obtained from HeLa cells in association with p131sucl activate inactive type-1 protein phosphatase (PP1) (catalytic subunit · inhibitor-2 complex, purified from skeletal muscle).
Villa-Moruzzi, Emma, Emma Villa-Moruzzi
core   +1 more source