Results 71 to 80 of about 29,264 (228)

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase [PDF]

, 2011
Background: Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form ...
Walker, Roderick G., Brown, Elaine, Thomson, Graeme, Blake, David G., Malone, Kirk, Turner, Nicholas J., Grant, Karen, Mottram, Jeremy C., Walkinshaw, Malcolm D., Nowicki, Matthew W.   +9 more
core   +3 more sources

Boron Neutron Capture Therapy Eliminates Radioresistant Liver Cancer Cells by Targeting DNA Damage and Repair Responses [Corrigendum]

Journal of Hepatocellular Carcinoma, 2023
Huang CY, Lai ZY, Hsu TJ, Chou FI, Liu HM, Chuang YJ. J Hepatocell Carcinoma. 2022;9:1385–1401. The authors have advised due to an error at the time of figure assembly, Figure 7A on page 1395 is incorrect.
Huang CY, Lai ZY, Hsu TJ, Chou FI, Liu HM, Chuang YJ   +5 more
doaj  

Single cell RNA-Seq reveals pre-cDCs fate determined by transcription factor combinatorial dose

BMC Molecular and Cell Biology, 2019
Background Classic dendritic cells (cDCs) play a central role in the immune system by processing and presenting antigens to activate T cells, and consist of two major subsets: CD141+ cDC (cDC1) and CD1c+ cDC (cDC2).
Wenji Ma, Jaeyop Lee, Daniel Backenroth, Yu Jerry Zhou, Erin Bush, Peter Sims, Kang Liu, Yufeng Shen   +7 more
doaj   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

S. mansoni -derived omega-1 prevents OVA-specific allergic airway inflammation via hampering of cDC2 migration.

PLoS Pathogens
Chronic infection with Schistosoma mansoni parasites is associated with reduced allergic sensitization in humans, while schistosome eggs protects against allergic airway inflammation (AAI) in mice.
Thiago A Patente, Thomas A Gasan, Maaike Scheenstra, Arifa Ozir-Fazalalikhan, Katja Obieglo, Sjoerd Schetters, Stijn Verwaerde, Karl Vergote, Frank Otto, Ruud H P Wilbers, Eline van Bloois, Yolanda van Wijck, Christian Taube, Hamida Hammad, Arjen Schots, Bart Everts, Maria Yazdanbakhsh, Bruno Guigas, Cornelis H Hokke, Hermelijn H Smits   +19 more
doaj   +1 more source

Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology

Journal of the Chinese Chemical Society, EarlyView.
Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley   +1 more source

Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III

, 2002
The availability of a sister chromatid, and thus the cell cycle phase in which DNA double-strand breaks (DSBs) occur, influences the choice between homologous recombination (HR) or nonhomologous end joining (NHEJ).
Jo Murray (4460464), Thomas Caspari (155113), Antony Carr (4561024)   +2 more
core   +1 more source

Glucose to lactate shift reprograms CDK-dependent mitotic decisions and its communication with MAPK Sty1 in Schizosaccharomyces pombe

Biology Open, 2023
Priyanka Sarkar, Susmita Misra, Agamani Ghosal, Soumyajit Mukherjee, Alok Ghosh, Geetanjali Sundaram   +5 more
doaj   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source