Results 1 to 10 of about 531,349 (289)

The design of peptide-based substrates for the cdc2 protein kinase. [PDF]

Biochemical Journal, 1995
The substrate sequence specificity of the cdc2 protein kinase from Pisaster ochraceus has been evaluated. The peptide, Ac-Ser-Pro-Gly-Arg-Arg-Arg-Arg-Lys-amide, serves as an efficient cdc2 kinase substrate with a Km of 1.50 +/- 0.04 microM and a Vmax. of
J. Srinivasan, M. Koszelak, M. Mendelow, Y. Kwon, D. Lawrence   +4 more
semanticscholar   +4 more sources

The Efficacy of Hellebrigenin Against Nasopharyngeal Carcinoma Cells: The Molecular and Bioinformatic Analysis. [PDF]

J Cell Mol Med
ABSTRACT Nasopharyngeal carcinoma (NPC) is a unique cancer type originating from the nasopharynx. To investigate novel strategies for improving prognosis and reducing the adverse effects of current treatments, this study examined the efficacy of hellebrigenin.
Ho HY, Chen MK, Tsai YJ, Lin CC, Lo YS, Chuang YC, Hsieh MJ.   +6 more
europepmc   +2 more sources

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3 [PDF]

ChemMedChem, 2011
New drugs are urgently needed for the treatment of tropical parasitic diseases such as leishmaniasis and human African trypanosomiasis (HAT). This work involved a high‐throughput screen of a focussed kinase set of ∼3400 compounds to identify potent and ...
Laura A. T. Cleghorn, Andrew Woodland, I. Collie, L. S. Torrie, Neil R. Norcross, Torsten Luksch, C. Mpamhanga, Roderick G. Walker, J. Mottram, R. Brenk, J. Frearson, I. Gilbert, P. Wyatt   +12 more
semanticscholar   +5 more sources

Regulation of the vertebrate cell cycle by the cdc2 protein kinase.

Cold Spring Harbor Symposia on Quantitative Biology, 1988
A homolog of the cdc2/CDC28 protein kinase of yeast is found in all vertebrate species that have been investigated. Human cdc2 exists as a complex with a 13-kD protein that is homologous to the suc1 gene product of fission yeast.
G. Draetta, L. Brizuela, B. Moran, D. Beach   +3 more
semanticscholar   +4 more sources

The Cdc2 protein kinase controls Cdc10/Sct1 complex formation.

Molecular Biology of the Cell, 1997
In the fission yeast Schizosaccharomyces pombe, the execution of Start requires the activity of the Cdc2 protein kinase and the Cdc10/Sct1 transcription complex. The loss of any of these genes leads to G1 arrest and activation of the mating pathway under
T. Connolly, M. Caligiuri, D. Beach
semanticscholar   +5 more sources

A Novel cdc2‐Related Protein Kinase Expressed in the Nervous System [PDF]

Journal of Neurochemistry, 1997
Abstract: We report the cloning and characterization of a cDNA encoding a cdc2‐related protein kinase, named PFTAIRE, that is expressed primarily in the postnatal and adult nervous system. We have demonstrated by in situ hybridization and indirect immunofluorescence that several populations of terminally differentiated neurons and some neuroglia ...
M. Lazzaro, P. Albert, J. Julien
semanticscholar   +3 more sources

PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. [PDF]

Proceedings of the National Academy of Sciences, 1994
Members of the cell division cycle 2 (CDC2) family of kinases play a pivotal role in the regulation of the eukaryotic cell cycle. In this communication, we report the isolation of a cDNA that encodes a CDC2-related human protein kinase temporarily ...
X. Graña, A. D. Luca, N. Sang, Yan Fu, P. Claudio, J. Rosenblatt, D. Morgan, A. Giordano   +7 more
semanticscholar   +7 more sources

The mammalian cdc2 protein kinase: mechanisms of regulation during the cell cycle

Journal of Cell Science, 1989
Summary Recent experimental evidence has demonstrated the central role of the cdc2 protein kinase in the transition from G2 to M phase in eukaryotic cells.
G. Draetta, D. Beach
semanticscholar   +4 more sources

Interaction of Neuronal Cdc2-like Protein Kinase with Microtubule-associated Protein Tau* [PDF]

Journal of Biological Chemistry, 2000
Neuronal Cdc2-like protein kinase (NCLK), a ∼58-kDa heterodimer, was isolated from neuronal microtubules (Ishiguro, K., Takamatsu, M., Tomizawa, K., Omori, A., Takahashi, M., Arioka, M., Uchida, T. and Imahori, K. (1992) J. Biol. Chem. 267, 10897–10901).
K. Sobue, A. Agarwal-Mawal, Wei Li, Weiguo Sun, Yutaka Miura, H. Paudel   +5 more
semanticscholar   +3 more sources

The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2. [PDF]

Molecular Biology of the Cell, 1995
The Cdc2 protein kinase is a key regulator of the G1-S and G2-M cell cycle transitions in the fission yeast Schizosaccharomyces pombe. The activation of Cdc2 at the G2-M transition is triggered by dephosphorylation at a conserved tyrosine residue Y15 ...
G. D. Haese, N. Walworth, A. Carr, K. Gould   +3 more
semanticscholar   +4 more sources