Results 11 to 20 of about 33,667 (166)

Microtubule-Targeting Drugs Induce Bcl-2 Phosphorylation and Association with Pin1

Neoplasia: An International Journal for Oncology Research, 2001
Bcl-2 is a critical suppressor of apoptosis that is overproduced in many types of cancer. Phosphorylation of the Bcl-2 protein is induced on serine residues in tumor cells arrested by microtubule-targeting drugs (paclitaxel, vincristine, nocodazole) and ...
Nuzhat Pathan, Christine Aime-sempe, Shinichi Kitada, Subrata Haldar, John C. Reed   +4 more
doaj   +1 more source

Checkpoint-Dependent Regulation of Origin Firing and Replication Fork Movement in Response to DNA Damage in Fission Yeast [PDF]

, 2009
To elucidate the checkpoint mechanism responsible for slowing passage through S phase when fission yeast cells are treated with the DNA-damaging agent methyl methanesulfonate (MMS), we carried out two-dimensional gel analyses of replication intermediates
Huberman, Joel A., Kumar, Sanjay
core   +3 more sources

Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs

Marine Drugs, 2010
For development to proceed normally, animal eggs must undergo a maturation process that ultimately depends on phosphorylations of key regulatory proteins.
Alicia Marquardt, Samuel Abernathy, Jose R. Escalona, Stephen A. Stricker   +3 more
doaj   +1 more source

Synergistic Effect of MC-LR and C-Terminal Truncated HBx on HepG2 Cells and Their Effects on PP2A Mediated Downstream Target of MAPK Signaling Pathway

Frontiers in Genetics, 2020
C-terminally truncated hepatitis B virus (HBV) X (ctHBx) infection and exposure to microcystins-LR (MC-LR) can lead to human hepatitis and liver cancer, but the mechanism associated with their synergistically effects not been fully elucidated. The ctHBx (
Chanchan Xiao, Fanbiao Mei, Guanhua Ren, Long Long, Maojian Chen, Xiang Fang, Jilin Li, Kezhi Li, Yanping Tang, Tianren Huang, Wei Deng   +10 more
doaj   +1 more source

Raptor is phosphorylated by cdc2 during mitosis. [PDF]

PLoS ONE, 2010
The appropriate control of mitotic entry and exit is reliant on a series of interlocking signaling events that coordinately drive the biological processes required for accurate cell division.
Dana M Gwinn, John M Asara, Reuben J Shaw   +2 more
doaj   +1 more source

Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease [PDF]

, 2005
We have recently reported that a polymorphism in the cell division cycle (CDC2) gene, designated Ex6 + 7I/D, is associated with Alzheimer's disease (AD). The CDC2 gene is located on chromosome 10q21.1 close to the marker D10S1225 linked to AD.
Andreasen N, Annica Johansson, Blennow K, Braak E, Bybee A, Donovan N, Dranovsky A, Evan G, Farrer LA, Feilotter H, Georgi AB, Giovanni A, Grana X, Harald Hampel, Hardy J, Henrik Zetterberg, Husseman JW, Hyman AA, Johansson A, Jonathan A. Prince, Jordan-Sciutto K, Kaj Blennow, Katharina Buerger, Kitamura Y, Kobayashi S, Konishi Y, Lars-Olof Wahlund, Ledesma MD, Lennart Minthon, Lindwall G, Liu DX, McKhann G, Meyer JM, Mirra SS, Nagy Z, Pei JJ, Simpson NE, Strittmatter WJ, Suzuki T, Vanderstichele H, Vincent I, Vulliet R, Zhang J   +42 more
core   +1 more source

Western blot analysis of Src kinase assays using peptide substrates ligated to a carrier protein

BioTechniques, 2004
We have applied intein-mediated peptide ligation (IPL) to the use of peptide substrates for kinase assays and subsequent Western blot analysis. IPL allows for the efficient ligation of a synthetic peptide with an N-terminal cysteine residue to an intein ...
Jie Xu, Luo Sun, Inca Ghosh, Ming-Qun Xu
doaj   +1 more source

The dynamic organization of fungal acetyl-CoA carboxylase [PDF]

, 2016
Acetyl-CoA carboxylases (ACCs) catalyse the committed step in fatty-acid biosynthesis: the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. They are important regulatory hubs for metabolic control and relevant drug targets for the treatment of ...
Hagmann, Anna, Hunkeler, Moritz, Imseng, Stefan, Maier, Timm, Stuttfeld, Edward   +4 more
core   +1 more source

Functional characterization of the diatom cyclin-dependent kinase A2 as a mitotic regulator reveals plant-like properties in a non-green lineage [PDF]

, 2015
Background: Cyclin-dependent kinases (CDKs) are crucial regulators of cell cycle progression in eukaryotes. The diatom CDKA2 was originally assigned to the classical A-type CDKs, but its cell cycle phase-specific transcription at the G2-to-M phase ...
Bowler, Chris, De Veylder, Lieven, Huysman, Marie, Tanaka, Atsuko, Vyverman, Wim   +4 more
core   +2 more sources

Biological functions of CDK5 and potential CDK5 targeted clinical treatments. [PDF]

, 2017
Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit.
Casimiro, Mathew C., Pestell, Richard G., Shupp, Alison   +2 more
core   +2 more sources