Results 11 to 20 of about 531,349 (289)
cdc2 protein kinase: interactions with cyclins and suc1. [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 1991 P. Brambilla, B. Ducommun, G. Draetta
semanticscholar +3 more sources
Boolean network model predicts cell cycle sequence of fission yeast [PDF]
, 2007 A Boolean network model of the cell-cycle regulatory network of fission yeast (Schizosaccharomyces Pombe) is constructed solely on the basis of the known biochemical interaction topology.
A Faure +40 more
core +15 more sources
Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. [PDF]
PLoS ONE, 2011 During a normal cell cycle, the transition from G₂ phase to mitotic phase is triggered by the activation of the cyclin B1-dependent Cdc2 kinase. Here we report our finding that treatment of MCF-7 human breast cancer cells with nocodazole, a prototypic ...
Hye Joung Choi +2 more
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Identification of a Wee1-like kinase gene essential for procyclic Trypanosoma brucei survival. [PDF]
PLoS ONE, 2013 Regulation of eukaryotic cell cycle progression requires sequential activation and inactivation of cyclin-dependent kinases (CDKs). Activation of the cyclin B-cdc2 kinase complex is a pivotal step in mitotic initiation and the tyrosine kinase Wee1 is a ...
Natalia Y Boynak +6 more
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Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression. [PDF]
Proceedings of the National Academy of Sciences, 1992 Recent studies have shown that there exists a family of protein kinases structurally and functionally related to the yeast cell cycle regulatory kinase cdc2 [Meyerson, M., Faha, B., Su, L.-K., Harlow, E. & Tsai, L.-H. (1991) Cold Spring Harbor Symp. Quant. Biol. 56, 177-186 and Meyerson, M., Enders, G. H., Wu, C.-L., Su, L.-K., Gorka, C., Nelson, C.
Mark R. Hellmich +3 more
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Inferring Compensatory Kinase Networks in Yeast using Prolog [PDF]
EPTCS 385, 2023, pp. 260-273, 2023 Signalling pathways are conserved across different species, therefore making yeast a model organism to study these via disruption of kinase activity. Yeast has 159 genes that encode protein kinases and phosphatases, and 136 of these have counterparts in humans.
arxiv +1 more source
Cell Death and Disease, 2023 The outcome of the disease visceral leishmaniasis (VL), caused by Leishmania donovani (LD), largely relies on the relative dominance of host-protective type-1 T helper (Th1) cell response versus disease-promoting type-2 T helper (Th2) cell response.
Manish Mishra +4 more
doaj +1 more source
A family of human cdc2-related protein kinases. [PDF]
The EMBO Journal, 1992 The p34cdc2 protein kinase is known to regulate important transitions in the eukaryotic cell cycle. We have identified 10 human protein kinases based on their structural relation to p34cdc2. Seven of these kinases are novel and the products of five share greater than 50% amino acid sequence identity with p34cdc2.
Ed Harlow +7 more
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The Retinoblastoma Protein Physically Associates with the Human cdc2 Kinase [PDF]
Molecular and Cellular Biology, 1992 The protein product (pRB) of the retinoblastoma susceptibility gene functions as a negative regulator of cell proliferation, and its activity appears to be modulated by phosphorylation. Using a new panel of anti-human pRB monoclonal antibodies, we have investigated the biochemical properties of this protein. These antibodies have allowed us to detect a
Ed Harlow +3 more
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Role of protein phosphorylation in cell signaling, disease, and the intervention therapy
MedComm, 2022 Protein phosphorylation is an important post‐transcriptional modification involving an extremely wide range of intracellular signaling transduction pathways, making it an important therapeutic target for disease intervention.
Kun Pang +10 more
doaj +1 more source