Results 21 to 30 of about 33,736 (233)

Over expression of Plk1 does not induce cell division in rat cardiac myocytes in vitro. [PDF]

PLoS ONE, 2009
BACKGROUND:Mammalian cardiac myocytes withdraw from the cell cycle during post-natal development, resulting in a non-proliferating, fully differentiated adult phenotype that is unable to repair damage to the myocardium, such as occurs following a ...
Carmen H Coxon, Katrina A Bicknell, Fleur L Moseley, Gavin Brooks   +3 more
doaj   +1 more source

Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells. [PDF]

PLoS ONE, 2010
Histone deacetylase inhibitors (HDACis) are promising anticancer drugs; however, the molecular mechanisms leading to HDACi-induced cell death have not been well understood and no clear mechanism of resistance has been elucidated to explain limited ...
William Brazelle, Jenny M Kreahling, Jennifer Gemmer, Yihong Ma, W Douglas Cress, Eric Haura, Soner Altiok   +6 more
doaj   +1 more source

Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core

Molecules, 2022
The DYRK (Dual-specificity tyrosine phosphorylation-regulated kinase) family of protein kinases is involved in the pathogenesis of several neurodegenerative diseases.
Mihaela-Liliana Ţînţaş, Ludovic Peauger, Florent Alix, Cyril Papamicaël, Thierry Besson, Jana Sopková-de Oliveira Santos, Vincent Gembus, Vincent Levacher   +7 more
doaj   +1 more source

A family of human cdc2-related protein kinases. [PDF]

The EMBO Journal, 1992
The p34cdc2 protein kinase is known to regulate important transitions in the eukaryotic cell cycle. We have identified 10 human protein kinases based on their structural relation to p34cdc2. Seven of these kinases are novel and the products of five share greater than 50% amino acid sequence identity with p34cdc2.
M, Meyerson, G H, Enders, C L, Wu, L K, Su, C, Gorka, C, Nelson, E, Harlow, L H, Tsai   +7 more
openaire   +2 more sources

Morphological analysis of CDC2 and glycogen synthase kinase 3β phosphorylation as markers of g2 → m transition in glioma. [PDF]

, 2011
G2 → M transition is a strategic target for glioma chemotherapy. Key players in G2 → M transition include CDC2 and glycogen synthase kinase 3β (GSK3β), which are highly regulated by posttranslational phosphorylation.
Otero, José Javier, Tihan, Tarik
core   +3 more sources

Mitotic Regulation of Protein 4.1R Involves Phosphorylation by cdc2 Kinase [PDF]

Molecular Biology of the Cell, 2005
The nonerythrocyte isoform of the cytoskeletal protein 4.1R (4.1R) is associated with morphologically dynamic structures during cell division and has been implicated in mitotic spindle function. In this study, we define important 4.1R isoforms expressed in interphase and mitotic cells by RT-PCR and mini-cDNA library construction. Moreover, we show that
Shu-Ching, Huang, Eva S, Liu, Siu-Hong, Chan, Indira D, Munagala, Heidi T, Cho, Ramasamy, Jagadeeswaran, Edward J, Benz   +6 more
openaire   +2 more sources

The Retinoblastoma Protein Physically Associates with the Human cdc2 Kinase [PDF]

Molecular and Cellular Biology, 1992
The protein product (pRB) of the retinoblastoma susceptibility gene functions as a negative regulator of cell proliferation, and its activity appears to be modulated by phosphorylation. Using a new panel of anti-human pRB monoclonal antibodies, we have investigated the biochemical properties of this protein. These antibodies have allowed us to detect a
Q J, Hu, J A, Lees, K J, Buchkovich, E, Harlow   +3 more
openaire   +2 more sources

Activation of type‐1 protein phosphatase by cdc2 kinase [PDF]

FEBS Letters, 1992
Purified cdc2 or cdc2 obtained from HeLa cells in association with p131sucl activate inactive type‐1 protein phosphatase (PP1) (catalytic subunit · inhibitor‐2 complex, purified from skeletal muscle). Likewise in the case of PP1 activation by FA/GSK3, activation by cdc2 is accompanied by phosphorylation of inhibitor‐2 (I2) and free I2 can be ...
openaire   +2 more sources

Functional interaction of fibroblast growth factor 8b and androgen in prostate cancer cell proliferation

Tumor Biology, 2017
Fibroblast growth factor 8b and androgen play important roles in cell proliferation of prostate cancer. We investigated the effects of fibroblast growth factor 8b and androgen on the proliferation of prostate cell lines and the corresponding ...
Wen-jun Xiao, Gui-ming Zhang, Ding-wei Ye   +2 more
doaj   +1 more source

Role of Pentacyclic Triterpenoids in Chemoprevention and Anticancer Treatment: An Overview on Targets and Underling Mechanisms

Journal of Pharmacopuncture, 2019
DNA: Deoxyribonucleic acid, BRCA1: Breast cancer gene 1, BRCA2: Breast cancer gene 2,WHO: World Health Organization, Nrf2: Nuclear factor erythroid 2 [NF-E2]-related factor 2 , NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells, MDR ...
Mahavir H. Ghante, Prasad G. Jamkhande
doaj   +1 more source