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Are physiological oscillations physiological?
The Journal of Physiology, EarlyView., 2023 Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley +1 more source
The Protein-tyrosine Kinase Lck Associates with and Is Phosphorylated by Cdc2 [PDF]
Journal of Biological Chemistry, 1996 The protein-tyrosine kinase Lck is essential for signaling through the T-cell antigen receptor. Treatment of T-cells with a variety of extracellular stimuli increases the phosphorylation of Lck on serine residues. This results in shifts in the apparent molecular weight of Lck to forms that exhibit reduced electrophoretic mobility on SDS-polyacrylamide ...
Robert L. Geahlen +2 more
openaire +3 more sources
Scientific Reports, 2021 Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity of splice factors and of ...
Simon Uzor +11 more
doaj +1 more source
Over expression of Plk1 does not induce cell division in rat cardiac myocytes in vitro. [PDF]
PLoS ONE, 2009 BACKGROUND:Mammalian cardiac myocytes withdraw from the cell cycle during post-natal development, resulting in a non-proliferating, fully differentiated adult phenotype that is unable to repair damage to the myocardium, such as occurs following a ...
Carmen H Coxon +3 more
doaj +1 more source
Learning Induces a CDC2-Related Protein Kinase, KKIAMRE [PDF]
The Journal of Neuroscience, 1999 To elucidate molecular mechanisms in learning and memory, we analyzed expression of mRNAs in brains of rabbits undergoing eyeblink conditioning. Infusion of the transcription inhibitor actinomycin D into the cerebellar interpositus nucleus reversibly blocked learning but not performance of the conditioned response.
Richard F. Thompson +6 more
openaire +3 more sources
Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells. [PDF]
PLoS ONE, 2010 Histone deacetylase inhibitors (HDACis) are promising anticancer drugs; however, the molecular mechanisms leading to HDACi-induced cell death have not been well understood and no clear mechanism of resistance has been elucidated to explain limited ...
William Brazelle +6 more
doaj +1 more source
Molecules, 2022 The DYRK (Dual-specificity tyrosine phosphorylation-regulated kinase) family of protein kinases is involved in the pathogenesis of several neurodegenerative diseases.
Mihaela-Liliana Ţînţaş +7 more
doaj +1 more source
The Xenopus Suc1/Cks Protein Promotes the Phosphorylation of G2/M Regulators [PDF]
, 1999 The entry into mitosis is controlled by Cdc2/cyclin B, also known as maturation or M-phase promoting factor (MPF). In Xenopus egg extracts, the inhibitory phosphorylations of Cdc2 on Tyr-15 and Thr-14 are controlled by the phosphatase Cdc25 and the ...
Dunphy, William G. +3 more
core +1 more source
Microtubule-Targeting Drugs Induce Bcl-2 Phosphorylation and Association with Pin1
Neoplasia: An International Journal for Oncology Research, 2001 Bcl-2 is a critical suppressor of apoptosis that is overproduced in many types of cancer. Phosphorylation of the Bcl-2 protein is induced on serine residues in tumor cells arrested by microtubule-targeting drugs (paclitaxel, vincristine, nocodazole) and ...
Nuzhat Pathan +4 more
doaj +1 more source
Reactivation of the mitosis-promoting factor in postmitotic cardiomyocytes [PDF]
, 2003 Cardiomyocytes cease to divide shortly after birth and an irreversible cell cycle arrest is evident accompanied by the downregulation of cyclin-dependent kinase activities.
Datwyler, D. A. +5 more
core +1 more source