Results 31 to 40 of about 531,349 (289)
European Journal of Biochemistry, 1990 The M-phase-specific cdc2 (cell division control) protein kinase (a component of the M-phase-promoting factor) was found to activate casein kinase II in vitro. The increase in casein kinase II activity ranged over 1.5-5-fold.
O. Mulner-lorillon +6 more
semanticscholar +1 more source
Morphological analysis of CDC2 and glycogen synthase kinase 3β phosphorylation as markers of g2 → m transition in glioma. [PDF]
, 2011 G2 → M transition is a strategic target for glioma chemotherapy. Key players in G2 → M transition include CDC2 and glycogen synthase kinase 3β (GSK3β), which are highly regulated by posttranslational phosphorylation.
Otero, José Javier, Tihan, Tarik
core +3 more sources
Marine Drugs, 2010 For development to proceed normally, animal eggs must undergo a maturation process that ultimately depends on phosphorylations of key regulatory proteins.
Alicia Marquardt +3 more
doaj +1 more source
Frontiers in Genetics, 2020 C-terminally truncated hepatitis B virus (HBV) X (ctHBx) infection and exposure to microcystins-LR (MC-LR) can lead to human hepatitis and liver cancer, but the mechanism associated with their synergistically effects not been fully elucidated. The ctHBx (
Chanchan Xiao +10 more
doaj +1 more source
Raptor is phosphorylated by cdc2 during mitosis. [PDF]
PLoS ONE, 2010 The appropriate control of mitotic entry and exit is reliant on a series of interlocking signaling events that coordinately drive the biological processes required for accurate cell division.
Dana M Gwinn +2 more
doaj +1 more source
Regulation of Nuclear Envelope Assembly/Disassembly by MAP Kinase [PDF]
, 1996 Mouse eggs arrested in metaphase II display high levels of cdc2/cyclin B1 and MAP protein kinase activities. Following fertilization there is a time-dependent decrease in the activity of each of these protein kinases.
Kopf, Gregory S. +3 more
core +1 more source
Western blot analysis of Src kinase assays using peptide substrates ligated to a carrier protein
BioTechniques, 2004 We have applied intein-mediated peptide ligation (IPL) to the use of peptide substrates for kinase assays and subsequent Western blot analysis. IPL allows for the efficient ligation of a synthetic peptide with an N-terminal cysteine residue to an intein ...
Jie Xu, Luo Sun, Inca Ghosh, Ming-Qun Xu
doaj +1 more source
Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins [PDF]
PLoS Comput Biol. 2008 Jun 27;4(6):e1000099, 2008 Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an appropriate biological response. Although scaffolds are widely believed to have dramatic effects on the dynamics of signal propagation, the mechanisms that underlie these consequences are not well ...
arxiv +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1996 In eukaryotes, tight regulatory mechanisms ensure the ordered progression through the cell cycle phases. The mechanisms that prevent chromosomal DNA replication from taking place more than once each cell cycle are thought to involve the function of ...
Mary Hendrickson +3 more
semanticscholar +1 more source
Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45 [PDF]
Oncogene, 1999 Recently Gadd45, a p53-regulated stress protein, has been implicated in the activation of a G2/M checkpoint after damage by UV radiation and alkylating agents. While inhibitory phosphorylation of Cdc2 and suppression of cyclin B1 levels are known to be involved in G2 delays after genotoxic stress, Gadd45 has now been found to directly inhibit the ...
Albert J. Fornace +8 more
openaire +3 more sources