Results 51 to 60 of about 33,736 (233)

Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin

Molecules, 2017
HER2/neu positive breast tumors predict a high mortality and comprise 25%–30% of breast cancer. We have shown that Flavokawain A (FKA) preferentially reduces the viabilities of HER2-overexpressing breast cancer cell lines (i.e., SKBR3 and MCF7/HER2 ...
Danielle D. Jandial, Lauren S. Krill, Lixia Chen, Chunli Wu, Yu Ke, Jun Xie, Bang H. Hoang, Xiaolin Zi   +7 more
doaj   +1 more source

Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress. [PDF]

PLoS Pathogens, 2009
The nuclear lamina is a major obstacle encountered by herpesvirus nucleocapsids in their passage from the nucleus to the cytoplasm (nuclear egress).
Sofia Hamirally, Jeremy P Kamil, Yasmine M Ndassa-Colday, Alison J Lin, Wan Jin Jahng, Moon-Chang Baek, Sarah Noton, Laurie A Silva, Martha Simpson-Holley, David M Knipe, David E Golan, Jarrod A Marto, Donald M Coen   +12 more
doaj   +1 more source

Regulation of Op18 during Spindle Assembly in Xenopus Egg Extracts [PDF]

, 2001
Oncoprotein 18 (Op18) is a microtubule-destabilizing protein that is negatively regulated by phosphorylation. To evaluate the role of the three Op18 phosphorylation sites in Xenopus (Ser 16, 25, and 39), we added wild-type Op18, a nonphosphorylatable ...
Andersen, Andersen, Arnaud, Bahler, Belmont, Brattsand, Carmena, Cassimeris, Charles, Curmi, Curmi, Desai, Desai, Descombes, Di Paolo, Felix, Gard, Gavet, Gigant, Glover, Golsteyn, Gruss, Hamanaka, Heald, Heald, Heald, Heald, Hirano, Horwitz, Howell, Howell, Hyman, Jourdain, Karaiskou, Kotani, Kumagai, Kumagai, Lane, Larsson, Lawler, Llamazares, Logarinho, Luo, Marklund, Maucuer, McKim, Moutinho-Santos, Murray, Nachury, Nigg, Ohkura, Qian, Qian, Sandaltzopoulos, Sawin, Schubart, Shirayama, Steinmetz, Sunkel, Taagepera, Tournebize, Vernos, Walczak, Wallon, Wianny, Wiese, Wray, Zhang   +67 more
core   +4 more sources

The design of peptide-based substrates for the cdc2 protein kinase [PDF]

Biochemical Journal, 1995
The substrate sequence specificity of the cdc2 protein kinase from Pisaster ochraceus has been evaluated. The peptide, Ac-Ser-Pro-Gly-Arg-Arg-Arg-Arg-Lys-amide, serves as an efficient cdc2 kinase substrate with a Km of 1.50 +/- 0.04 microM and a Vmax. of 12.00 +/- 0.18 mumol/min per mg.
J, Srinivasan, M, Koszelak, M, Mendelow, Y G, Kwon, D S, Lawrence   +4 more
openaire   +2 more sources

Computer-Aided Drug Design Applied to Marine Drug Discovery: Meridianins as Alzheimer’s Disease Therapeutic Agents

Marine Drugs, 2017
Computer-aided drug discovery/design (CADD) techniques allow the identification of natural products that are capable of modulating protein functions in pathogenesis-related pathways, constituting one of the most promising lines followed in drug discovery.
Laura Llorach-Pares, Alfons Nonell-Canals, Melchor Sanchez-Martinez, Conxita Avila   +3 more
doaj   +1 more source

Down-regulatory mechanism of mammea E/BB from Mammea siamensis seed extract on Wilms' Tumor 1 expression in K562 cells. [PDF]

, 2016
BackgroundWilms' tumor 1 (WT1) is a biological marker for predicting leukemia progression. In this study, mammea E/BB, an active compound from Saraphi (Mammea siamensis) seed extract was examined for its effect on down-regulatory mechanism of WT1 gene ...
Ampasavate, Chadarat, Anuchapreeda, Songyot, Katekunlaphan, Trinnakorn, Okonogi, Siriporn, Rungrojsakul, Methee, Saiai, Aroonchai, Sweeney, Colleen A   +6 more
core   +1 more source

Cdc2-like kinases: structure, biological function and therapeutic targets for diseases

Signal Transduction and Targeted Therapy, 2023
The CLKs (Cdc2-like kinases) belong to the dual-specificity protein kinase family and play crucial roles in regulating transcript splicing via the phosphorylation of SR proteins (SRSF1–12), catalyzing spliceosome molecular machinery, and modulating the ...
Mengqiu Song, Luping Pang, Mengmeng Zhang, Yingzi Qu, Kyle Vaughn Laster, Zigang Dong   +5 more
doaj   +1 more source

The Xenopus Suc1/Cks Protein Promotes the Phosphorylation of G2/M Regulators [PDF]

, 1999
The entry into mitosis is controlled by Cdc2/cyclin B, also known as maturation or M-phase promoting factor (MPF). In Xenopus egg extracts, the inhibitory phosphorylations of Cdc2 on Tyr-15 and Thr-14 are controlled by the phosphatase Cdc25 and the ...
Dunphy, William G., Kumagai, Akiko, Patra, Debabrata, Wang, Sophie X.   +3 more
core   +1 more source

A Novel cdc2‐Related Protein Kinase Expressed in the Nervous System [PDF]

Journal of Neurochemistry, 1997
Abstract: We report the cloning and characterization of a cDNA encoding a cdc2‐related protein kinase, named PFTAIRE, that is expressed primarily in the postnatal and adult nervous system. We have demonstrated by in situ hybridization and indirect immunofluorescence that several populations of terminally differentiated neurons and some neuroglia ...
M A, Lazzaro, P R, Albert, J P, Julien
openaire   +2 more sources

High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase. [PDF]

PLoS Neglected Tropical Diseases, 2011
Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form an active ...
Roderick G Walker, Graeme Thomson, Kirk Malone, Matthew W Nowicki, Elaine Brown, David G Blake, Nicholas J Turner, Malcolm D Walkinshaw, Karen M Grant, Jeremy C Mottram   +9 more
doaj   +1 more source