Results 51 to 60 of about 531,349 (289)

T-loop phosphorylation of Arabidopsis CDKA;1 is required for its function and can be partially substituted by an aspartate residue [PDF]

, 2007
As in other eukaryotes, progression through the cell cycle in plants is governed by cyclin-dependent kinases. Phosphorylation of a canonical Thr residue in the T-loop of the kinases is required for high enzyme activity in animals and yeast.
, Dissmeyer, N., Grini, P., Inzé, D., Nowack, M., Pusch, S., Schnittger, A., Stals, H.   +7 more
core   +2 more sources

Mitotic Regulation of Protein 4.1R Involves Phosphorylation by cdc2 Kinase [PDF]

Molecular Biology of the Cell, 2005
The nonerythrocyte isoform of the cytoskeletal protein 4.1R (4.1R) is associated with morphologically dynamic structures during cell division and has been implicated in mitotic spindle function. In this study, we define important 4.1R isoforms expressed in interphase and mitotic cells by RT-PCR and mini-cDNA library construction. Moreover, we show that
Ramasamy Jagadeeswaran, Eva S. Liu, Heidi T. Cho, Edward J. Benz, Shu-Ching Huang, Indira D. Munagala, Siu-Hong Chan   +6 more
openaire   +2 more sources

Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition – implications for the next generation of DC vaccines

OncoImmunology, 2019
Current treatments for glioblastoma (GBM) have limited efficacy and significant morbidity and therefore new strategies are urgently needed. Dendritic cells have the power to create anti-tumor immune responses. The greater potency of circulating dendritic
Jason Adhikaree, Hester Ann Franks, Constantinos Televantos, Poonam Vaghela, Aanchal Preet Kaur, David Walker, Marc Schmitz, Andrew Mark Jackson, Poulam Manubhai Patel   +8 more
doaj   +1 more source

Caffeine as a tool for investigating the integration of Cdc25 phosphorylation, activity and ubiquitin-dependent degradation in Schizosaccharomyces pombe

Cell Division, 2020
The evolutionarily conserved Cdc25 phosphatase is an essential protein that removes inhibitory phosphorylation moieties on the mitotic regulator Cdc2. Together with the Wee1 kinase, a negative regulator of Cdc2 activity, Cdc25 is thus a central regulator
John P. Alao, Per Sunnerhagen
doaj   +1 more source

p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]

, 2005
In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Bertrand, Philippe, Bretteville, Alexis, Buée, Luc, Bégard, Séverine, Delacourte, André, Hamdane, Malika, Sambo, Anne-Véronique, Schindowski, Katharina   +7 more
core   +1 more source

Bacillus subtilis KLBMPGC81 suppresses appressorium-mediated plant infection by altering the cell wall integrity signaling pathway and multiple cell biological processes in Magnaporthe oryzae

Frontiers in Cellular and Infection Microbiology, 2022
Magnaporthe oryzae is one of the most destructive crop pathogens in the world, causing huge losses in rice harvest every year. Bacillus subtilis is a potential biocontrol agent that has been explored in many crop systems because it is a potent producer ...
Lianwei Li, Yanru Li, Kailun Lu, Rangrang Chen, Jihong Jiang   +4 more
doaj   +1 more source

Advance in Reversible Covalent Kinase Inhibitors [PDF]

arXiv, 2021
Reversible covalent kinase inhibitors (RCKIs) are a class of novel kinase inhibitors attracting increasing attention because they simultaneously show the selectivity of covalent kinase inhibitors, yet avoid permanent protein-modification-induced adverse effects.
arxiv  

Positional information readout in $Ca^{2+}$ signaling [PDF]

Phys. Rev. Lett. 123, 058102 (2019), 2017
Living cells respond to spatial signals. Signal transmission to the cell interior often involves the release of second messengers like $Ca^{2+}$ . They will eventually trigger a physiological response by activating kinases that in turn activate target proteins through phosphorylation. Here, we investigate theoretically how positional information can be
arxiv   +1 more source

Pre-M Phase-promoting Factor Associates with Annulate Lamellae in Xenopus Oocytes and Egg Extracts [PDF]

, 2003
We have used complementary biochemical and in vivo approaches to study the compartmentalization of M phase-promoting factor (MPF) in prophase Xenopus eggs and oocytes. We first examined the distribution of MPF (Cdc2/CyclinB2) and membranous organelles in
Alfa C.E., Argon Y., Ashcroft N.R., Audit M., Bagley S., Bailly E., Bailly E., Bal A.K., Beaudouin J., Beckhelling C., Beckhelling C., Borgne A., Brunati A.M., Charrasse S., Clute P., Cordes V.C., Cyert M.S., Dabauvalle M.C., De Souza C.P., Detlaff T.A., Dumont J.N., Edgar B.A., Felix M.A., Gautier J., Gerhart J.C., Hagting A., Hang J., Hara K., Hartley R.S., Heim R., Imreh G., Iwao Y., Iwao Y., Iwashita J., Jackman M., Kallenbach R.J., Kessel R.G., Kimelman D., Kobayashi H., Laemmli U.K., Leiss D., Li J., Lindsay H.D., Liu F., Masui Y., Masui Y., Meier E., Moreno S., Morgan D.O., Morgan D.O., Murray A., Murray A.W., Newport J., Nigg E.A., Norbury C., Novak B., Nurse P., O'Farrell P.H., Ohi R., Ookata K., Pante N., Pines J., Pitt J.N., Pockwinse S.M., Pérez-Mongiovi D., Pérez-Mongiovi D., Raff J.W., Rankin S., Reinsch S., Rieder C.L., Roegiers F., Sakamoto I., Salina D., Shinagawa A., Shinagawa A., Shinagawa A., Solomon M.J., Takahashi Y., Takizawa C.G., Wakefield J.G., Xu X., Yang J., Zernicka-Goetz M.   +82 more
core   +2 more sources

Reversal of terminal differentiation and control of DNA replication [PDF]

, 1993
DNA replication in mammalian cells occurs in discrete nuclear foci. Here we show that terminally differentiated myotubes can be induced to reenter S phase and show the same pattern of replication foci as cycling cells.
Cardoso, M. Cristina, Leonhardt, Heinrich, Nadal-Ginard, Bernardo   +2 more
core   +1 more source