Results 81 to 90 of about 33,736 (233)

GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling [PDF]

, 2015
The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates nutrient and growth factor signals for the co-ordinated regulation of cellular metabolism and cell ...
Alan Prescott, Averous, Avruch, Azoulay-Alfaguter, Bain, Bar-Peled, Bar-Peled, Bradford, Carriere, Carriere, Clare Stretton, Coghlan, Cross, Demetriades, Dibble, Doble, Fonseca, Foster, Frey, Ganley, Garcia-Martinez, Gwinn, Gwinn, Hajduch, Hara, Harinder S. Hundal, Hosokawa, Ian G. Ganley, Inoki, Inoki, Inoki, Jewell, Jung, Kelleher, Kim, Kim, Kwak, Lipina, MacAulay, Marchand, Martina, Meijer, Menon, Michael J. Munson, Oshiro, Oshiro, Parr, Peter M. Taylor, Pfaffl, Ramirez-Valle, Rebsamen, Sancak, Shin, Smith, Stretton, Sutherland, Thorsten M. Hoffmann, Wang, Wang, Yoon, Zoncu   +60 more
core   +3 more sources

The Cdc2 protein kinase controls Cdc10/Sct1 complex formation.

Molecular Biology of the Cell, 1997
In the fission yeast Schizosaccharomyces pombe, the execution of Start requires the activity of the Cdc2 protein kinase and the Cdc10/Sct1 transcription complex. The loss of any of these genes leads to G1 arrest and activation of the mating pathway under appropriate conditions.
T, Connolly, M, Caligiuri, D, Beach
openaire   +3 more sources

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1 [PDF]

, 2001
In a screen designed to discover suppressors of mitotic catastrophe, we identified the Xenopus ortholog of 53BP1 (X53BP1), a BRCT protein previously identified in humans through its ability to bind the p53 tumor suppressor.
Carpenter, Phillip B., Dunphy, William G., Morales, Julio C., Xia, Zhenfang   +3 more
core  

p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]

, 2005
In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Bertrand, Philippe, Bretteville, Alexis, Buée, Luc, Bégard, Séverine, Delacourte, André, Hamdane, Malika, Sambo, Anne-Véronique, Schindowski, Katharina   +7 more
core   +1 more source

Regulation of the Vertebrate Cell Cycle by the cdc2 Protein Kinase

Cold Spring Harbor Symposia on Quantitative Biology, 1988
A homolog of the cdc2/CDC28 protein kinase of yeast is found in all vertebrate species that have been investigated. Human cdc2 exists as a complex with a 13-kD protein that is homologous to the suc1 gene product of fission yeast. In both human and fission yeast cells, the protein kinase also exists in a complex with a 62-kD polypeptide that has not ...
G, Draetta, L, Brizuela, B, Moran, D, Beach   +3 more
openaire   +2 more sources

Hinokiflavone induces apoptosis, cell cycle arrest and autophagy in chronic myeloid leukemia cells through MAPK/NF-κB signaling pathway

BMC Complementary Medicine and Therapies, 2022
Background Chronic myeloid leukemia (CML) is a myeloproliferative tumor originating from hematopoietic stem cells, and resistance to tyrosine kinase inhibitors (TKI) has become a major cause of treatment failure.
Xiang Qin, Xi Chen, Ling Guo, Jing Liu, You Yang, Yan Zeng, Cheng Li, Wenjun Liu, Wenzhe Ma   +8 more
doaj   +1 more source

Pre-M Phase-promoting Factor Associates with Annulate Lamellae in Xenopus Oocytes and Egg Extracts [PDF]

, 2003
We have used complementary biochemical and in vivo approaches to study the compartmentalization of M phase-promoting factor (MPF) in prophase Xenopus eggs and oocytes. We first examined the distribution of MPF (Cdc2/CyclinB2) and membranous organelles in
Alfa C.E., Argon Y., Ashcroft N.R., Audit M., Bagley S., Bailly E., Bailly E., Bal A.K., Beaudouin J., Beckhelling C., Beckhelling C., Borgne A., Brunati A.M., Charrasse S., Clute P., Cordes V.C., Cyert M.S., Dabauvalle M.C., De Souza C.P., Detlaff T.A., Dumont J.N., Edgar B.A., Felix M.A., Gautier J., Gerhart J.C., Hagting A., Hang J., Hara K., Hartley R.S., Heim R., Imreh G., Iwao Y., Iwao Y., Iwashita J., Jackman M., Kallenbach R.J., Kessel R.G., Kimelman D., Kobayashi H., Laemmli U.K., Leiss D., Li J., Lindsay H.D., Liu F., Masui Y., Masui Y., Meier E., Moreno S., Morgan D.O., Morgan D.O., Murray A., Murray A.W., Newport J., Nigg E.A., Norbury C., Novak B., Nurse P., O'Farrell P.H., Ohi R., Ookata K., Pante N., Pines J., Pitt J.N., Pockwinse S.M., Pérez-Mongiovi D., Pérez-Mongiovi D., Raff J.W., Rankin S., Reinsch S., Rieder C.L., Roegiers F., Sakamoto I., Salina D., Shinagawa A., Shinagawa A., Shinagawa A., Solomon M.J., Takahashi Y., Takizawa C.G., Wakefield J.G., Xu X., Yang J., Zernicka-Goetz M.   +82 more
core   +2 more sources

Limited utility of qPCR-based detection of tumor-specific circulating mRNAs in whole blood from clear cell renal cell carcinoma patients [PDF]

, 2020
BACKGROUND: RNA sequencing data is providing abundant information about the levels of dysregulation of genes in various tumors. These data, as well as data based on older microarray technologies have enabled the identification of many genes which are ...
Busch, Jonas, Hinze, Christian, Jung, Klaus, Jung, Monika, Rabien, Anja, Schmidt-Ott, Kai M., Simonovic, Sinisa   +6 more
core   +2 more sources

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source