Results 1 to 10 of about 137,554 (368)
Structural insights into the functional diversity of the CDK–cyclin family [PDF]
Open Biology, 2018 Since their characterization as conserved modules that regulate progression through the eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are now also emerging as significant regulators of transcription, metabolism
Daniel J. Wood, Jane A. Endicott
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New functional activities for the p21 family of CDK inhibitors. [PDF]
Genes & Development, 1997 The association of cdk4 with D-type cyclins to form functional kinase complexes is comparatively inefficient. This has led to the suggestion that assembly might be a regulated step. In this report we demonstrate that the CDK inhibitors p21(CIP), p27(KIP),
J. LaBaer +7 more
semanticscholar +2 more sources
Lineage-specific CDK activity dynamics characterize early mammalian development [PDF]
Cell ReportsSummary: Cyclin-dependent kinases (CDKs) regulate proliferation dynamics and cell fate in response to extracellular inputs. It remains largely unknown how CDK activity fluctuates and influences cell commitment during early mammalian development. Here, we
Bechara Saykali +8 more
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Targeting CDKs in cancer therapy: advances in PROTACs and molecular glues [PDF]
npj Precision OncologyEssential transcription and cell cycle progression controllers are CDKs, whose dysregulation is a defining trait of many human cancers. CDKs have grown to be very crucial therapeutic targets in cancer.
Hany E. Marei +7 more
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Customer Appointment Analysis in Automobile Dealerships
Proceedings of the International Florida Artificial Intelligence Research Society Conference, 2022 Appointment scheduling prior to in-person visit to vehicle service centers is a well-known activity in our daily lives; we often do that to save our- selves time during our visits.
Priya Saha +2 more
doaj +1 more source
California school lead testing results and the new lead and copper rule
Water Practice and Technology, 2022 Under the revised lead and copper rule, schools and daycare centers will need to conduct lead and copper sampling. The California Division of Drinking Water required Public Water Systems to assist local schools in testing water for lead between 2017 and ...
David Eugene Kimbrough
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A study of lead service lines in California
Water Practice and Technology, 2022 Under new regulations In the USA, all Community Water Systems (CWS) need to develop an inventory of their lead service lines (LSL) and determine those owned by their customers. This study will present an approach to address this issue that meets both the
David Eugene Kimbrough
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A Journey through Time on the Discovery of Cell Cycle Regulation
Cells, 2022 All living organisms on Earth are made up of cells, which are the functional unit of life. Eukaryotic organisms can consist of a single cell (unicellular) or a group of either identical or different cells (multicellular).
Rustem Uzbekov, Claude Prigent
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European Journal of Haematology, 2021 Cyclin‐dependent kinase (CDK) 4/6 inhibitors are integral treatment for advanced hormone receptor positive breast cancer; however, venous thromboembolic events (VTE) occurred in 1%‐5% of clinical trial patients. Thrombosis rates in the real‐world setting
M. West +9 more
semanticscholar +1 more source
CDK-dependent nuclear localization of B-Cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast [PDF]
, 2013 Cyclin-dependent kinases (CDK) are master regulators of the cell cycle in eukaryotes. CDK activity is regulated by the presence, post-translational modification and spatial localization of its regulatory subunit cyclin.
A Sourirajan +38 more
core +6 more sources