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Targeting CDKs in cancer therapy: advances in PROTACs and molecular glues [PDF]
npj Precision OncologyEssential transcription and cell cycle progression controllers are CDKs, whose dysregulation is a defining trait of many human cancers. CDKs have grown to be very crucial therapeutic targets in cancer.
Hany E. Marei +7 more
doaj +2 more sources
CDK-dependent nuclear localization of B-Cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast [PDF]
, 2013 Cyclin-dependent kinases (CDK) are master regulators of the cell cycle in eukaryotes. CDK activity is regulated by the presence, post-translational modification and spatial localization of its regulatory subunit cyclin.
A Sourirajan +38 more
core +14 more sources
Customer Appointment Analysis in Automobile Dealerships
Proceedings of the International Florida Artificial Intelligence Research Society Conference, 2022 Appointment scheduling prior to in-person visit to vehicle service centers is a well-known activity in our daily lives; we often do that to save our- selves time during our visits.
Priya Saha +2 more
doaj +1 more source
CDK signaling via nonconventional CDK phosphorylation sites
Molecular Biology of the Cell, 2023 Since the discovery of cyclin-dependent kinases (CDKs), it has been perceived as a dogma that CDK signaling in the cell cycle is mediated via targeting the CDK consensus sites: the optimal and the minimal motifs S/T-P-x-K/R and S/T-P, respectively.
Valk, Ervin +3 more
openaire +2 more sources
A Journey through Time on the Discovery of Cell Cycle Regulation
Cells, 2022 All living organisms on Earth are made up of cells, which are the functional unit of life. Eukaryotic organisms can consist of a single cell (unicellular) or a group of either identical or different cells (multicellular).
Rustem Uzbekov, Claude Prigent
doaj +1 more source
CDK control pathways integrate cell size and ploidy information to control cell division
eLife, 2021 Maintenance of cell size homeostasis is a property that is conserved throughout eukaryotes. Cell size homeostasis is brought about by the co-ordination of cell division with cell growth and requires restriction of smaller cells from undergoing mitosis ...
James Oliver Patterson +3 more
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CDK1/2/5 blockade: killing two birds with one stone
OncoImmunology, 2021 Pancreatic ductal adenocarcinoma (PDAC) is an immune resistant tumor. We recently demonstrated that inhibiting CDK1/2/5 by dinaciclib not only blocks immune checkpoint expression, but also triggers histone-dependent immunogenic cell death.
Jiao Liu, Rui Kang, Daolin Tang
doaj +1 more source
Biotechnology Reports, 2021 Introduction: Colorectal cancer (CRC) is one of the most cancer-related mortalities worldwide and remains a major public health issue. Despite several attempts to develop promising therapies for CRC, its survival rate decreases with metastasis.
Adewale Oluwaseun Fadaka +5 more
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Heliyon, 2023 Climatic droplet keratopathy (CDK) is a corneal diseases, which is characterized by increased oil-like deposits on the anterior elastic lamina and anterior stromal layer. Severe CDK can even cause blindness, with no specific available treatment. Besides.
Zhixiang Hua +8 more
doaj +1 more source
Aaptamine attenuates the proliferation and progression of non-small cell lung carcinoma
Pharmaceutical Biology, 2020 Context Aaptamine is a potent ocean-derived non-traditional drug candidate against human cancers. However, the underlying molecular mechanisms governing aaptamine-mediated repression of lung cancer cells remain largely undefined. Objective To examine the
Kaikai Gong +8 more
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