The plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis [PDF]
, 2004 Transgenic Arabidopsis thaliana plants overproducing the E2Fa-DPa transcription factor have two distinct cell-specific phenotypes: some cells divide ectopically and others are stimulated to endocycle.
Beemster, Gerrit +8 more
core +3 more sources
Chemistry &Biodiversity, EarlyView.Metabolites from fungi isolated from protease rich‐fruits displayed antifungal, antitrypanosomal and enzymatic inhibitory activities. ABSTRACT Fungal secondary metabolites display remarkable chemical diversity and biological potential, with applications in agriculture and pharmaceuticals. This study isolated and characterized bioactive metabolites from
Gabriela de Oliveira Almeida +8 more
wiley +1 more source
Comparing EEG patterns of actual and imaginary wrist movements - a machine learning approach [PDF]
, 2005 Our goal is to develop an algorithm for feature extraction and classification to be used in building brain-computer interfaces. In this paper, we present preliminary results for classifying EEG data of imaginary wrist movements.
Conway, B.A., Lakany, H.
core
Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells [PDF]
, 2014 Background Although MYC is an attractive therapeutic target for breast cancer treatment, it has proven challenging to inhibit MYC directly, and clinically effective pharmaceutical agents targeting MYC are not yet available. An alternative approach is to
Kang, Jian +3 more
core +2 more sources
Cdks set the replication schedule [PDF]
Journal of Cell Biology, 2010 The cyclin-dependent kinases (Cdks) have an even bigger role in DNA replication than researchers thought, [Thomson et al.][1] reveal. The enzymes not only activate individual replication sites, they also control the large-scale pattern of DNA duplication by turning on clusters of replication ...
openaire +2 more sources
In Vivo Biosynthesis and Direct Incorporation of Non‐Canonical Amino Acids into Proteins
ChemBioChem, Accepted Article.Autonomous cells are engineered biological systems capable of biosynthesising and directly incorporating non‐canonical amino acids (ncAAs) into proteins. These systems have the potential to extend the applicability of the genetic code to enable large‐scale fermentative production of proteins carrying ncAAs.
Ivana Drienovska +2 more
wiley +1 more source
Immunomodulation as a Potent COVID-19 Pharmacotherapy: Past, Present and Future
Journal of Inflammation Research, 2021 Decsa Medika Hertanto,1,2 Bayu Satria Wiratama,3,4 Henry Sutanto,5,6 Citrawati Dyah Kencono Wungu7,8 1Department of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, Indonesia; 2Department of Internal Medicine, Dr.
Hertanto DM +3 more
doaj
A single cyclin–CDK complex is sufficient for both mitotic and meiotic progression in fission yeast
Nature Communications, 2015 The dominant model for eukaryotic cell cycle control proposes that cell cycle progression is driven by a succession of CDK complexes with different substrate specificities.
P. Gutierrez-Escribano, P. Nurse
semanticscholar +1 more source
Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix. [PDF]
, 2019 The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inactivation by ...
Cristea, Sandra +8 more
core
Ecography, EarlyView.The processes driving defense trait correlations may vary within and between species based on ecological or environmental contexts. However, most studies of plant defense theory fail to address this potential for shifts in trait correlations across scales.
Carolyn D. K. Graham, Marjorie G. Weber
wiley +1 more source