Results 151 to 160 of about 138,770 (367)

Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment

Molecular Nutrition &Food Research, EarlyView.
Effect of Natural Polyphenols on Breast Cancer proliferation and progression. ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and cancer treatments in the past decade; however, the complexity and heterogeneity of certain breast cancer subtypes often lead to ...
Marzia Sichetti, Martina Giuseffi, Eugenia Giglio, Graziella Marino, Marisabel Mecca   +4 more
wiley   +1 more source

Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway

iScience, 2023
Summary: Wee1-like protein kinase (WEE1) restrains activities of cyclin-dependent kinases (CDKs) in S and G2 phase. Inhibition of WEE1 evokes drastic increase in CDK activity, which perturbs replication dynamics and compromises cell cycle checkpoints ...
Valdemaras Petrosius, Jan Benada, Olaf Nielsen, Erwin M. Schoof, Claus Storgaard Sørensen   +4 more
doaj  

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation [PDF]

, 1999
A. Montagnoli, Frédéric Di Fiore, Esther Eytan, Andrea C. Carrano, Giulio Draetta, Avram Hershko, Michele Pagano   +6 more
openalex   +1 more source

Salen‐Type Copper(II) Complexes: Synthesis, Characterization, Computational Studies, Molecular Docking, Anticancer Potential, and Pharmacokinetic Prediction

ChemistryOpen, EarlyView.
Integrating synthesis, density functional theory studies, molecular docking, cytotoxicity, and ADMET predictions, this study identifies [CuII(salen)(H2O)2] (2) as a selective anticancer agent. Docking and in vitro assays highlight its favorable target interactions, selective anticancer activity, and reduced toxicity toward normal fibroblasts ...
Abdellatif A. Helaly, Bandar A. Babgi, Yoji Kobayashi, Rohit K. Rai, Ehab M. M. Ali, Abdulaziz A. Kalantan, Walid M. I. Hassan, Mostafa A. Hussien, Muhammad M. I. Ismail   +8 more
wiley   +1 more source

p27Xic1, a Cdk Inhibitor, Promotes the Determination of Glial Cells in Xenopus Retina [PDF]

, 1999
Shin‐ichi Ohnuma, Anna Philpott, Ke Wang, Christine E. Holt, William A. Harris   +4 more
openalex   +1 more source

Learning Information Spread in Content Networks

, 2013
We introduce a model for predicting the diffusion of content information on social media. When propagation is usually modeled on discrete graph structures, we introduce here a continuous diffusion model, where nodes in a diffusion cascade are projected ...
Bourigault, Simon, Denoyer, Ludovic, Gallinari, Patrick, Lagnier, Cédric, Lamprier, Sylvain   +4 more
core   +2 more sources

Dual role of CDKs in DNA repair: To be, or not to be

DNA Repair, 2009
The maintenance of genome integrity is essential for the regulation of cell proliferation and differentiation. DNA must be accurately duplicated and segregated to daughter cells at cell division, a process that is primarily regulated by cyclin-dependent kinases (CDKs).
Yata, K, Esashi, F
openaire   +3 more sources

Thiostrepton Suppresses the Progression of Rhabdomyosarcoma by Inhibiting the PI3K‐AKT Signaling Pathway

Pediatric Discovery, EarlyView.
The study establish TST as a multi‐mechanism PI3K‐AKT inhibitor for refractory RMS while validating Cmap‐driven drug repurposing for pediatric oncology. ABSTRACT Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma with 5‐year survival below 30% in high‐risk/metastatic cases, was investigated through integrated bioinformatics analysis (
Yu Wang, Peng Hong, Zhiqiang Gao, Wei Ma, Zaihong Hu, Jie Lin, Kongkong Cui, Qinlin Shi, Xiao‐Mao Tian, Guanghui Wei   +9 more
wiley   +1 more source

Retinoblastoma Protein Contains a C-terminal Motif That Targets It for Phosphorylation by Cyclin-cdk Complexes [PDF]

, 1999
Peter D. Adams, Xiaotong Li, William R. Sellers, Kayla Baker, Xiaohong Leng, J. Wade Harper, Yoichi Taya, William G. Kaelin   +7 more
openalex   +1 more source

Phytoestrogen Signal Pathways and Estrogen Signaling in Ovarian Cancer: A Narrative Review

Phytotherapy Research, EarlyView.
Phytoestrogen signal pathways targeted in ovarian cancer. ABSTRACT Ovarian cancer (OC) is the second most common gynecological cancer and the leading cause of death from gynecological malignancies. Ovarian cancer mortality rate ranks fifth among cancer‐related deaths in Western societies.
Ozgur Kutuk, Ayse Kaplan
wiley   +1 more source