Results 161 to 170 of about 138,770 (367)
Molecular Ecology Resources, EarlyView.ABSTRACT Reliable tools for the identification of genetic sex are invaluable in many fields of biology, but their design requires knowledge of sex‐linked sequences, which is lacking in many taxa. Restriction‐site‐associated DNA sequencing (RADseq) is widely used to identify sex‐linked markers, but multiple distinct strategies are employed, and it is ...
James France +4 more
wiley +1 more source
Human and Yeast Cdk-activating Kinases (CAKs) Display Distinct Substrate Specificities [PDF]
, 1998 Philipp Kaldis +4 more
openalex +1 more source
Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration
Aging Cell, EarlyView.Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Jonathan Plessis‐Belair +3 more
wiley +1 more source
Inhibition of Myogenesis by Multiple Cyclin-Cdk Complexes [PDF]
, 1997 Kun Guo, Kenneth Walsh
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Aging Cell, EarlyView.Therapeutic plasma exchange safely reduces biological age by up to 2.6 years. Multi‐omics analysis reveals coordinated cellular and molecular responses associated with aging rejuvenation. ABSTRACT We conducted a randomized, placebo‐controlled trial to assess the safety and biological age (BA) effects of various therapeutic plasma exchange (TPE ...
Matias Fuentealba +14 more
wiley +1 more source
Cdk family genes are expressed not only in dividing but also in terminally differentiated mouse germ cells, suggesting their possible function during both cell division and differentiation [PDF]
, 1995 Kunsoo Rhee, Debra J. Wolgemuth
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Aging Cell, EarlyView.Severe short‐term energy restriction in adults with prediabetes led to a significant reduction in circulating proteins linked to inflammation, senescence, and protein turnover. These changes, partly mediated by extracellular vesicles, suggest systemic dietary‐induced benefits beyond glycemic control, including improved aging biomarkers.
Maria Lastra Cagigas +16 more
wiley +1 more source
Aging Cell, EarlyView.In the CA1, microglia are activated to be responsible for synaptic pruning. However, LPS induces a senescent phenotype in microglia, characterized by the elevated levels of p16, as well as the production of SASPs. These senescent microglia mediate the removal of excitatory synapses selectively, resulting in dendritic spine loss and LTP impairment ...
Kai Liu +8 more
wiley +1 more source
Iron overload and morbidities in Chinese with non‐transfusion‐dependent thalassaemia
British Journal of Haematology, EarlyView.A cross‐sectional study in Hong Kong included 109 adult and paediatric Chinese patients with non‐transfusion dependent thalassaemia (NTDT). The study found significant chronic health issues in 52% of patients. More severe disease was observed in patients with non‐deletional α‐thalassaemia intermedia, β‐thalassaemia intermedia, advanced age and history ...
Wing‐yan Leung +19 more
wiley +1 more source
Epidermal growth factor increases the level of the cyclin-dependent kinase (CDK) inhibitor p21/CIP1 (CDK-interacting protein 1) in A431 cells by increasing the half-lives of the p21/CIP1 transcript and the p21/CIP1 protein [PDF]
, 1999 Lene E. Johannessen +2 more
openalex +1 more source