Results 171 to 180 of about 138,770 (367)

Highly Coordinated Gene Regulation in Mouse Skeletal Muscle Regeneration [PDF]

, 2003
Mammalian skeletal muscles are capable of regeneration after injury. Quiescent satellite cells are activated to reenter the cell cycle and to differentiate for repair, recapitulating features of myogenesis during embryonic development.
Choi, Sangdun, Hart, Rebecca, Lee, Sun Young, Lin, Ling, Liu, Xuebin, Schageman, Jeoffrey J., Thurmond, Frederick A., Williams, R. Sanders, Yan, Zhen, Zhang, Mei   +9 more
core   +1 more source

Synergistic potential of CDK4/6 inhibitors and ATRA in non‐APL AML

British Journal of Haematology, EarlyView.
Summary Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by diverse genetic abnormalities. The standard of care remains to be chemotherapy and stem cell transplantation. In acute promyelocytic leukaemia (APL), differentiation therapy with all‐trans retinoic acid (ATRA) has significantly improved outcomes. Despite this, the success
Rafał Skopek, Setenay Gupse Özcan, Paulina Chmiel, Stephanie Morgner, Jaqueline Schütt, Faezeh Ghazvini Zadegan, Clara Stanko, Małgorzata Palusińska, Karolina Maślińska‐Gromadka, Yordan Sbirkov, Sven Stengel, Martin Fischer, Annamaria Brioli, Arthur Zelent, Łukasz Szymański, Tino Schenk   +15 more
wiley   +1 more source

CDK Inhibitors and FDA: Approved and Orphan

Cancers
The protein kinases are a large family of enzymes which catalyze protein phosphorylation at certain amino acids [...]
Jonas Cicenas, Jokubas Simkus
openaire   +3 more sources

Spliceosome protein alterations differentiate hubs of the default mode connectome during the progression of Alzheimer's disease

Brain Pathology, EarlyView.
Default mode network (DMN) consists, in part, of the frontal (FC), precuneus (PreC), and posterior cingulate cortex (PCC), which plays a critical role in episodic memory and retrieval of autobiographical memories, displays spatiotemporal differences in the onset of amyloid and hypometabolism that reflects tau neurodegeneration and loss of connectivity ...
Sylvia E. Perez, Muhammad Nadeem, Bin He, Jennifer C. Miguel, David G. Moreno, Marta Moreno‐Rodriguez, Michael Malek‐Ahmadi, Chadwick M. Hales, Elliott J. Mufson   +8 more
wiley   +1 more source

Requirement of PP2A-B56Par1 for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/CSte9 during Pre-Start G1 in S. pombe

iScience, 2020
Summary: Exit from the cell cycle during the establishment of quiescence and upon cell differentiation requires the sustained inactivation of CDK complexes.
Vilte Stonyte, Ruth Martín, Dario Segura-Peña, Nikolina Sekulić, Sandra Lopez-Aviles   +4 more
doaj  

SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities. [PDF]

, 1997
Rati Verma, R. M. Renny Feldman, Raymond J. Deshaies   +2 more
openalex   +1 more source

Dissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors

Nature Chemical Biology, 2020
P. Parua, R. Fisher
semanticscholar   +1 more source

HROB Induces Lung Adenocarcinoma Progression via ZC3HC1‐CCNB1 Axis Regulation and Cell Cycle Dysregulation

Cancer Science, EarlyView.
We have uncovered a novel mechanism by which HROB modulates cell proliferation in lung adenocarcinoma. Our findings suggest that HROB recruits ZC3HC1 and mediates its de‐phosphorylation at Ser354, which in turn promotes K27‐linked ubiquitination of CCNB1, leading to its proteasomal degradation.
Zhe Zhang, Cheng Wang, Yuanwei Guo, Zhenyu Zhao, Zhi Yang, Shouzhi Xie, Xinhang Hu, Xingchun Huang, Yupeng Jiang, Bing Xiao, Li Wang, Fenglei Yu, Bin Wang   +12 more
wiley   +1 more source

A Requirement for Cyclin D3–Cyclin-dependent Kinase (cdk)-4 Assembly in the Cyclic Adenosine Monophosphate–dependent Proliferation of Thyrocytes [PDF]

, 1998
Fabienne Depoortere, Alexandra Van Keymeulen, Jiří Lukáš, Sabine Costagliola, Jiřina Bártková, Jacques E. Dumont, Jiří Bártek, Pierre P. Roger, Sarah Dremier   +8 more
openalex   +1 more source

Aurora‐A Promotes Cell‐Cycle Progression From Quiescence Through Primary Cilia Disassembly

Cancer Science, EarlyView.
Our findings demonstrate that AurA facilitates cell cycle reentry by promoting primary cilia disassembly. Utilizing an inducible degron system, we showed that AurA depletion delays the G0/G1 transition, a defect rescued by forced deciliation. These results underscore AurA's role beyond mitosis and reinforce its potential as a therapeutic target in ...
Atsushi Kohso, Hironori Inaba, Masato T. Kanemaki, Esteban C. Gabazza, Hidemi Toyoda, Masahiro Hirayama, Hidemasa Goto   +6 more
wiley   +1 more source