Results 181 to 190 of about 125,522 (281)

Ruby CDK for Newbies

, 2007
Richard L. Apodaca
openalex   +1 more source

Identifying Susceptibility Genes and Shared Genetic Architecture for Longevity and Muscle Weakness

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Longevity and muscle strength are heritable traits, and age‐related muscle weakness is a major contributor to disability in older adults. However, the susceptibility genes and shared genetic mechanisms underlying lifespan and sarcopenia remain unclear.
Yilong Lin, Yun Zhang, Shengjie Lin, Songsong Wang, Zhiqiang Que, Yue Zhang, Jing She, Ruidan Zhao, Jiawei Chen, Anqi Qiu, Shinan Wu, Ruiqin Yang, Liyi Zhang, Qingmo Yang   +13 more
wiley   +1 more source

Evaluating the clinical utility of ctDNA testing to identify molecular cancer progression - lessons from SERENA-6. [PDF]

NPJ Breast Cancer
Taranto E, DeMichele A.
europepmc   +1 more source

Benefits of using SLGT2 Inhibitors for Patients with CDK and DM2 to Reduce Mortality Risks [PDF]

Fonseca Pandora Eloa Oliveira, Azevedo Jeremias Aguiar, Bié Sara Maria Gomes, Sávio Benvindo Ferreira   +3 more
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Supplementary Video 3 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

, 2023
Shuang Chen, Yun Dai, Xin‐Yan Pei, Jennifer S. Myers, Li Wang, Lora B. Kramer, Mandy Garnett, Daniella M. Schwartz, Florence Su, Gary Simmons, Justin D. Richey, Dustin G. Larsen, Paul Dent, Robert Z. Orlowski, Steven Grant   +14 more
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A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Combination of cyclin-dependent kinase 4/6 inhibitors and renin-angiotensin system inhibitors in breast cancer treatment: a promising therapeutic approach. [PDF]

Rev Assoc Med Bras (1992)
Mutlu E, İnanç M.
europepmc   +1 more source

Astrocyte Senescence Impairs Synaptogenesis due to Thrombospondin‐1 Loss

Aging Cell, Volume 25, Issue 2, February 2026.
Senescent hippocampal astrocytes lose TSP secretion, impairing excitatory synaptogenesis via the α2δ‐1 pathway. Restoring TSP‐1 rescues synaptic formation, revealing the contribution of astrocyte senescence to age‐related hippocampal synaptic decline.
Stefano Ercoli, Lucía Casares‐Crespo, Elena Juárez‐Escoto, Helena Mira   +3 more
wiley   +1 more source

Pan-cyclin-dependent kinase inhibition is a potential treatment for adenoid cystic carcinoma that downregulates the MYB::NFIB fusion and induces tumor regression. [PDF]

Cancer Commun (Lond)
Huang J, Larsson P, Kakay Afshari M, Tejera Nevado P, Tešan Tomić T, Fehr A, Jäwert F, Stenman G, Andersson MK.   +8 more
europepmc   +1 more source

P221: Exploring the Role of CDK- 4/6 Inhibitors and Aromatase Inhibitors as Neoadjuvant Therapy in Breast Cancer: Response Rates in Early and Advanced Diseases of Breast Cancer

D.S. SP, D.N. Semitha, Duszynski Kr, Deepak Kumar, Datta Patil, Vivek Duraivelu, Deepti Joshi   +6 more
openalex   +1 more source