Results 181 to 190 of about 138,770 (367)

CDK 4/6 Inhibitors in Breast Cancer: Current Controversies and Future Directions

Current Oncology Reports, 2019
Laura M. Spring, Seth A. Wander, Mark L. Zangardi, A. Bardia   +3 more
semanticscholar   +1 more source

Super‐Enhancer Target Gene CBP/p300‐Interacting Transactivator With Glu/Asp‐Rich C‐Terminal Domain, 2 Cooperates With Transcription Factor Forkhead Box J3 to Inhibit Pulmonary Vascular Remodeling

Cell Proliferation, EarlyView.
During hypoxia, the transcriptional effect of super‐enhancer in promoting CBP/p300‐interacting transactivator with Glu/Asp‐rich C‐terminal domain, 2 reduced, eventually leading to the thickening of the smooth muscle layer of the pulmonary artery.
Songyue Li, Jingya Zhang, Xu Wang, Xinru Wang, Yuyu Song, Xinyue Song, Xiuli Wang, Weiwei Cao, Chong Zhao, Jing Qi, Xiaodong Zheng, Yan Xing   +11 more
wiley   +1 more source

CELL CYCLE REGULATOR: CYCLIN DEPENDENT KINASE 10 AS POTENTIAL TARGET IN CANCER

Pakistan Journal of Medicine and Dentistry, 2019
Cell cycle progression through each phase is regulated by series of kinase family, the cyclin dependent kinases (CDK). To understand this CDK machinery that controls normal cell cycles, by forming CDK/cyclin complexes thus assisting the identification ...
Muhammad Fazal Hussain Qureshi, Mahira Lakhani, Muzna Shah, Shamim Mushtaq   +3 more
doaj  

The Pho85 kinase, a member of the yeast cyclin‐ dependent kinase (Cdk) family, has a regulation mechanism different from Cdks functioning throughout the cell cycle [PDF]

, 1999
Masafumi Nishizawa, Kohji Suzuki, Marie Fujino, Tomoko Oguchi, Akio Toh‐e   +4 more
openalex   +1 more source

The regulation of CDK activity by cyclins

, 2020
In eukaryotes, the two major cell cycle events of DNA replication and chromosome segregation are directed by Cyclin Dependent Kinases (CDKs) in combination with G1/S cyclins (S-CDK) and G2/M cyclins (M-CDK), respectively. It is still unclear what differentiates S-CDK activity from M-CDK activity, and how much functional redundancy exists between cyclin-
openaire   +3 more sources

Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules

Cell Proliferation, EarlyView.
A potent combination of small molecules YFSS (Y27632, Forskolin, SB431542, SP600125) that were screened through a neuronal‐specific promoter–reporter system TUBB3::mCherry effectively induces neuronal‐GBM conversion in vitro and in vivo, unveiling molecular mechanisms that offer a theoretical basis and a potential therapeutic strategy for treating GBM.
Ya'nan Hu, Jinming Liu, Jian Tu, Min Yang, Qisheng He, Fei Li, Xiaojing Xu, Zhongqing Ji, Jianwei Xu, Wentao Zhong, Mengwen Yan, Ying Yang, Huanxiang Zhang   +12 more
wiley   +1 more source

Transcriptional regulation of the CDK inhibitor p16INK4a gene by a novel pRb‐associated repressor, RBAR1 [PDF]

, 1999
Satoshi Kaneko, Junji Nishioka, Minoru Tanaka, Kunio Nakashima, Tsutomu Nobori   +4 more
openalex   +1 more source

Exploring the Single‐Cell Dynamics of FOXM1 Under Cell Cycle Perturbations

Cell Proliferation, EarlyView.
The varied FOXM1 dynamic patterns reveal significant differences in cellular responses to the same stimuli at the single‐cell level. This emphasises the relationship between cue, signal and response as influenced by different drug types and concentrations.
Tooba Jawwad, Maliwan Kamkaew, Kriengkrai Phongkitkarun, Porncheera Chusorn, Supawan Jamnongsong, Eric W.‐F. Lam, Somponnat Sampattavanich   +6 more
wiley   +1 more source

Correlations between the levels of vitamin D, parathormone, calcium, blood phosphates in patients with chronic disease of the kidneys untreated with replacement renal therapy

Терапевтический архив, 2009
Aim. To characterize correlations between the levels of vitamin D, parathormone, calcium, blood phosphates in patients with different stages of chronic disease of the kidney (CDK) given no therapy replacing renal function (TRRF).
Aleksey Vladimirovich Smirnov, Mikhail Mikhaylovich Volkov, Ol'ga Vladimirovna Galkina, Aleksandr Anatol'evich Zhloba, Vladimir Leonidovich Emanuel', A V Smirnov, M M Volkov, O V Galkina, A A Zhloba, V L Emanel   +9 more
doaj  

Synthetic Approaches and Clinical Application of Representative Small-Molecule Inhibitors of Cyclin-Dependent Kinase for Cancer Therapy

Molecules
The regulation of the cancer cell cycle heavily relies on cyclin-dependent kinases (CDKs). Targeting CDKs has been identified as a promising approach for effective cancer therapy.
Ya-Tao Wang, Shi-Qi Jiang, Shao-Lin Zhang   +2 more
doaj   +1 more source