Spinal cord injury markedly increases mortality and reduces life expectancy—greatest relative risk in younger individuals, greatest absolute risk in older adults. Findings highlight the need for age‐ and etiology‐specific long‐term management. ABSTRACT Background Spinal cord injury (SCI) is associated with substantial morbidity, premature mortality ...
Mahdi Safdarian +7 more
wiley +1 more source
Frontiers in Cell-Cycle-Targeting Therapies: Addressing the Heterogeneity of the Cancer Cell Cycle. [PDF]
Ganesan IP, Kiyokawa H.
europepmc +1 more source
Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner +3 more
wiley +1 more source
Nephrotoxicity secondary to CDK 4/6 inhibitors in advanced breast cancer patients and its impact on survival. [PDF]
Avci T +4 more
europepmc +1 more source
[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas [PDF]
Chen Y +6 more
europepmc +1 more source
The molecular aspects in prostatic cancer, unraveling the role of CDKs in prostate cancer progression. [PDF]
Farjami Z +4 more
europepmc +1 more source
Evolutionary constraints associated with functional specificity of the CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK, and CK2α [PDF]
Natarajan Kannan, Andrew F. Neuwald
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Structural basis of T-loop-independent recognition and activation of CDKs by the CDK-activating kinase. [PDF]
Cushing VI +8 more
europepmc +1 more source
Roscovitine is a proteostasis regulator that corrects the trafficking defect of
Caroline Norez +11 more
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Supplementary Figure S4 from Potent Antimyeloma Activity of a Novel ERK5/CDK Inhibitor
Stela Álvarez-Fernández +8 more
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