Results 91 to 100 of about 67,859 (329)
Distinct Cdk1 requirements during single-strand annealing, noncrossover, and crossover recombination. [PDF]
PLoS Genetics, 2011 Repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) in haploid cells is generally restricted to S/G2 cell cycle phases, when DNA has been replicated and a sister chromatid is available as a repair template.
Camilla Trovesi +4 more
doaj +1 more source
Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade. [PDF]
, 2020 Saturated fatty acids (SFAs) (the "bad" fat), especially palmitate (PA), in the human diet are blamed for potential health risks such as obesity and cancer because of SFA-induced lipotoxicity. However, epidemiological results demonstrate a latent benefit
Candas-Green, Demet +9 more
core
Chemical genetic analyses of quantitative changes in Cdk1 activity during the human cell cycle [PDF]
, 2013 Cyclin-dependent kinase 1 (Cdk1) controls cell proliferation and is inhibited by promising anticancer agents, but its mode of action and the consequences of its inhibition are incompletely understood.
Booth, A +4 more
core +3 more sources
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Frontiers in Bioengineering and Biotechnology, 2020 Hepatocellular carcinoma (HCC) is one of the important types of liver cancer. LncRNA is an important regulatory factor that regulates many biological processes such as tumor cells during tumorigenesis and metastasis.
Jinglan Jin +5 more
semanticscholar +1 more source
Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer [PDF]
, 2017 Cyclin-dependent kinase 1 (CDK1) is the central mammalian regulator of cell proliferation and a promising therapeutic target for breast cancer. In fact, CDK1 inhibition downregulates survival and induces apoptosis.
Galindo Moreno, María +5 more
core +2 more sources
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Compartmentalized control of Cdk1 drives mitotic spindle assembly
bioRxiv, 2021 During cell division, dramatic microtubular rearrangements driven by cyclin B-cdk1 (Cdk1) kinase activity mark mitosis onset leading to interphase cytoskeleton dissolution and mitotic spindle assembly.
Angela Flavia Serpico +3 more
semanticscholar +1 more source
Inhibition of CDK1 Reverses the Resistance of 5-Fu in Colorectal Cancer
Cancer Management and Research, 2020 Yiping Zhu,1 Kai Li,2 Jieling Zhang,2 Lu Wang,1 Lili Sheng,1 Liang Yan2 1Department of Oncology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, People’s Republic of China; 2Provincial Key Laboratory of Biological Macro ...
Zhu Y +5 more
doaj
Polarized Cell Growth: Double Grip by CDK1 [PDF]
Current Biology, 2007 Precise coupling of cell growth and cell-cycle progression is crucial for achieving cell homeostasis. A recent study sheds light on two distinct roles of cyclin-dependent kinase 1 (CDK1) in promoting polarized cell growth in budding yeast.
Giulia Rancati, Rong Li
openaire +3 more sources