Results 111 to 120 of about 35,931 (261)

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

open access: yesJournal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

COPS2 Antagonizes OCT4 to Accelerate the G2/M Transition of Mouse Embryonic Stem Cells

open access: yesStem Cell Reports, 2018
Summary: Proper regulation of the cell cycle is essential to safeguard the genomic integrity of embryonic stem cells (ESCs) while maintaining the fast proliferation rate.
Peng Li   +3 more
doaj  

LncRNA SOX21‐AS1 Promotes the Progression of Pancreatic Cancer by Sponging miR‐9‐3p and Upregulating YOD1

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pancreatic cancer (PC) is a highly aggressive malignancy of the digestive system. Recent studies have indicated that the long noncoding RNA SOX21‐AS1 is significantly upregulated in PC tissue samples. This study aims to elucidate the biological role and underlying molecular mechanisms of SOX21‐AS1 in PC progression. Quantitative real‐time PCR (
Han‐Bing Xu   +3 more
wiley   +1 more source

Differential expression of CDK1 in cancer of the cervix.

open access: yes, 2023
Almost all cervical cancers are caused by infection with high-risk human papillomaviruses (HPVs) (1-3); the transcriptional features that distinguish the gene expression programs of HPV-induced cancers from that of cancers resulting from non-viral abrogation of tumor suppression remain incompletely defined. We mined published microarray datasets (4, 5)
openaire   +1 more source

Crystal Structure–Activity Relationship of Some MeO Phenylacrylonitriles: Dual Antimicrobial–Cytotoxic Effects and in Silico Perspectives

open access: yesChemistryOpen, EarlyView.
Methoxy‐phenylacrylonitriles (2a–c) are synthesized and characterized by fourier‐transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and X‐ray crystallography (for 2a,b). Compound 2b shows selective cytotoxicity against MCF‐7 cells (IC50: 34 μM) and enhances activity against Gram‐positive bacteria. Molecular docking reveals strong
Leyla Babali Özen   +8 more
wiley   +1 more source

Combined evaluation of both WEE1 and phosphorylated cyclin dependent kinase 1 expressions in oral squamous cell carcinomas predicts cancer recurrence and progression

open access: yesJournal of Dental Sciences, 2022
Background/purpose: WEE1 is a mitotic inhibitor at G2 checkpoint of the cell cycle that negatively regulates cyclin-dependent kinase 1 (CDK1) through inhibitory phosphorylation.
Yu-Hsueh Wu   +3 more
doaj  

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