Results 111 to 120 of about 35,931 (261)

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

COPS2 Antagonizes OCT4 to Accelerate the G2/M Transition of Mouse Embryonic Stem Cells

Stem Cell Reports, 2018
Summary: Proper regulation of the cell cycle is essential to safeguard the genomic integrity of embryonic stem cells (ESCs) while maintaining the fast proliferation rate.
Peng Li, Nan Ding, Weiyu Zhang, Lingyi Chen   +3 more
doaj  

Hamartin and Tuberin Interaction With the G2/M Cyclin-Dependent Kinase CDK1 and Its Regulatory Cyclins A and B [PDF]

, 2001
Michael Catania, Paul S. Mischel, Harry V. Vinters   +2 more
openalex   +1 more source

LncRNA SOX21‐AS1 Promotes the Progression of Pancreatic Cancer by Sponging miR‐9‐3p and Upregulating YOD1

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pancreatic cancer (PC) is a highly aggressive malignancy of the digestive system. Recent studies have indicated that the long noncoding RNA SOX21‐AS1 is significantly upregulated in PC tissue samples. This study aims to elucidate the biological role and underlying molecular mechanisms of SOX21‐AS1 in PC progression. Quantitative real‐time PCR (
Han‐Bing Xu, Jian‐Tao Han, Cheng‐Peng Zhang, Bin Jiang   +3 more
wiley   +1 more source

Cdk1: A kinase with changing substrate specificity [PDF]

Cell Cycle, 2011
Mardo Kõivomägi, Mart Loog
openaire   +3 more sources

Differential expression of CDK1 in cancer of the cervix.

, 2023
Almost all cervical cancers are caused by infection with high-risk human papillomaviruses (HPVs) (1-3); the transcriptional features that distinguish the gene expression programs of HPV-induced cancers from that of cancers resulting from non-viral abrogation of tumor suppression remain incompletely defined. We mined published microarray datasets (4, 5)
openaire   +1 more source

Evidence for regulation of protein synthesis at the elongation step by CDK1/cyclin B phosphorylation [PDF]

, 2001
Annabelle Monnier
openalex   +1 more source

Crystal Structure–Activity Relationship of Some MeO Phenylacrylonitriles: Dual Antimicrobial–Cytotoxic Effects and in Silico Perspectives

ChemistryOpen, EarlyView.
Methoxy‐phenylacrylonitriles (2a–c) are synthesized and characterized by fourier‐transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and X‐ray crystallography (for 2a,b). Compound 2b shows selective cytotoxicity against MCF‐7 cells (IC50: 34 μM) and enhances activity against Gram‐positive bacteria. Molecular docking reveals strong
Leyla Babali Özen, Öner Ekici, Furkan Özen, Süleyman Berberler, Gül Özkan, Betül Yılmaz Öztürk, Pınar Oztopcu‐Vatan, Cansu Filik İşçen, Günseli Turgut Cin   +8 more
wiley   +1 more source

Combined evaluation of both WEE1 and phosphorylated cyclin dependent kinase 1 expressions in oral squamous cell carcinomas predicts cancer recurrence and progression

Journal of Dental Sciences, 2022
Background/purpose: WEE1 is a mitotic inhibitor at G2 checkpoint of the cell cycle that negatively regulates cyclin-dependent kinase 1 (CDK1) through inhibitory phosphorylation.
Yu-Hsueh Wu, Julia Yu-Fong Chang, Chun-Pin Chiang, Yi-Ping Wang   +3 more
doaj  

The mcm5-bob1 Bypass of Cdc7p/Dbf4p in DNA Replication Depends on Both Cdk1-Independent and Cdk1-Dependent Steps in Saccharomyces cerevisiae [PDF]

, 2002
Robert A. Sclafani, Marianne Tecklenburg, Angela Pierce   +2 more
openalex   +1 more source