Results 121 to 130 of about 69,053 (332)

Recurrent CDK1 overexpression in laryngeal squamous cell carcinoma [PDF]

Tumor Biology, 2016
In this study, we analyzed the expression profile of four genes (CCNA2, CCNB1, CCNB2, and CDK1) in laryngeal squamous cell carcinoma (LSCC) cell lines and tumor samples. With the application of microarray platform, we have shown the overexpression of these genes in all analyzed LSCC samples in comparison to non-cancer controls from head and neck region.
Katarzyna Kiwerska, Joanna Jackowska, Marcin Szaumkessel, Magdalena Kostrzewska-Poczekaj, Krzysztof Szyfter, Andrzej Marszałek, Maciej Giefing, Joanna Janiszewska, Kinga Bednarek, Malgorzata Jarmuz-Szymczak, Reidar Grénman, Anna Bartochowska, Magdalena Bodnar, Małgorzata Wierzbicka   +13 more
openaire   +4 more sources

CDK1 bridges NF-κB and β-catenin signaling in response to H. pylori infection in gastric tumorigenesis

Cell Reports, 2023
Summary: Infection with Helicobacter pylori (H. pylori) is the main risk factor for gastric cancer, a leading cause of cancer-related death worldwide.
Shoumin Zhu, Marwah Al-Mathkour, Longlong Cao, Shayan Khalafi, Zheng Chen, Julio Poveda, Dunfa Peng, Heng Lu, Mohammed Soutto, Tianling Hu, Oliver G. McDonald, Alexander Zaika, Wael El-Rifai   +12 more
doaj  

Biological functions of CDK5 and potential CDK5 targeted clinical treatments. [PDF]

, 2017
Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit.
Casimiro, Mathew C., Pestell, Richard G., Shupp, Alison   +2 more
core   +2 more sources

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Securin Is Not Required for Chromosomal Stability in Human Cells [PDF]

, 2005
Abnormalities of chromosome number are frequently observed in cancers. The mechanisms regulating chromosome segregation in human cells are therefore of great interest.
Azofeifa, Bunz, Cahill, Ciosk, Cohen-Fix, Funabiki, Giménez-Abián, Gorr, Gruber, Haering, Hauf, Hauf, Huang, Jallepalli, Jürgen Cox, Katrin Pfleghaar, Losada, McGuinness, Mei, Michael R Speicher, Michor, Nasmyth, Olaf Stemmann, R. Scott Hawley, Ramos-Morales, Saez, Simone Heubes, Speicher, Stemmann, Stemmann, Uhlmann, Waizenegger, Zou   +32 more
core   +4 more sources

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

Role of Cyclin-Dependent Kinase 1 in Translational Regulation in the M-Phase

Cells, 2020
Cyclin dependent kinase 1 (CDK1) has been primarily identified as a key cell cycle regulator in both mitosis and meiosis. Recently, an extramitotic function of CDK1 emerged when evidence was found that CDK1 is involved in many cellular events that are ...
Jaroslav Kalous, Denisa Jansová, Andrej Šušor   +2 more
doaj   +1 more source

MALMPS: A Machine Learning‐Based Metabolic Gene Prognostic Signature for Stratifying Clinical Outcomes and Molecular Heterogeneity in Stage II/III Colorectal Cancer

Advanced Science, EarlyView.
Chen et al. identified a metabolic gene prognostic signature with machine‐learning framework and assessed the prognostic value in independent CRC cohorts. The metabolic signature subtypes are characterized by specific metabolic and proteomic characteristics, and associated with distinct molecular pathway and therapeutic potential.
Hao Chen, Ze Wang, Chenglong Sun, Yang Zhong, Yuan Liu, Yikun Li, Tongchao Zhang, Yuan Zhang, Xingyu Zhu, Leping Li, Feifei Teng, Ming Lu, Wei Chong   +12 more
wiley   +1 more source

Identification and validation of CDK1 as a promising therapeutic target for Eriocitrin in colorectal cancer: a combined bioinformatics and experimental approach

BMC Cancer
Background Colorectal cancer (CRC) is a prevalent malignancy worldwide, associated with significant morbidity and mortality. Cyclin-dependent kinase 1 (CDK1) plays a crucial role in cell cycle regulation and has been implicated in various cancers.
Jiemiao Shen, Xing Gong, Haili Ren, Xia Tang, Hairong Yu, Yilu Tang, Shen Chen, Minghui Ji   +7 more
doaj   +1 more source

Cyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint

Journal of Cell Biology, 2020
Jackman and colleagues show that Cyclin B1-Cdk1, the major mitotic kinase, binds to the spindle checkpoint protein MAD1 and synergizes with MPS1 to facilitate MAD1 release from the nuclear pore complex and recruitment to kinetochores before nuclear ...
M. Jackman, C. Marcozzi, Martina Barbiero, M. Pardo, Lu Yu, A. Tyson, J. Choudhary, J. Pines   +7 more
semanticscholar   +1 more source