Results 161 to 170 of about 69,053 (332)

Approaches to repurposing reverse transcriptase antivirals in cancer

British Journal of Clinical Pharmacology, EarlyView.
This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head, Saiful Islam, Jennifer H. Martin   +2 more
wiley   +1 more source

Bioinformatics Analysis Reveals CDK1 and DLGAP5 as Key Modulators of Tumor Immune Cell Infiltration in Hepatocellular Carcinoma

Cancer Management and Research
Jiajing Li,1 Qi Liu,2 Ting Zhang,2 Qian Du3 1The Diagnostics Laboratory, Affiliated Hospital to Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 2Affiliated Hospital to Zunyi Medical University, Zunyi, Guizhou, 563000, People’
Li J, Liu Q, Zhang T, Du Q
doaj  

The oocyte spindle midzone pauses Cdk1 inactivation during fertilization to enable male pronuclear formation and embryo development

Cell Reports, 2022
Summary: Inactivation of cyclin-dependent kinase 1 (Cdk1), controlled by cyclin B1 proteolysis, orders events during mitotic exit. Here, we used a FRET biosensor to study Cdk1 activity while simultaneously monitoring anaphase II and pronuclear (PN ...
Chenxi Zhou, Hayden A. Homer
doaj  

Overexpression of BUB1B, CCNA2, CDC20, and CDK1 in tumor tissues predicts poor survival in pancreatic ductal adenocarcinoma

Bioscience Reports, 2019
Overexpressed genes in tumors usually contributed to aggressiveness in pancreatic ductal adenocarcinoma (PDAC). Using Gene Expression Omnibus (GEO) profiles including GSE46234, GSE71989, and GSE107610, we detected overexpressed genes in tumors with R ...
Shu Dong, Fei Huang, Hao Zhang, Qiwen Chen   +3 more
semanticscholar   +1 more source

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

CDK1 Inactivation Regulates Anaphase Spindle Dynamics and Cytokinesis In Vivo [PDF]

, 1997
Sally P. Wheatley, Edward H. Hinchcliffe, Michael Glotzer, Anthony A. Hyman, Greenfield Sluder, Yu-Li Wang   +5 more
openalex   +1 more source

Partial inhibition of Cdk1 in G2 phase overrides the SAC and decouples mitotic events

Cell Cycle, 2014
Entry and progression through mitosis has traditionally been linked directly to the activity of cyclin-dependent kinase 1 (Cdk1). In this study we utilized low doses of the Cdk1-specific inhibitor, RO3306 from early G2 phase onwards.
R. McCloy, Samuel Rogers, C. E. Caldon, T. Lorca, A. Castro, A. Burgess   +5 more
semanticscholar   +1 more source

NAT10 regulates tumor progression and immune microenvironment in pancreatic ductal adenocarcinoma via the N4‐acetylated LAMB3‐mediated FAK/ERK pathway

Cancer Communications, EarlyView.
Abstract Background N‐acetyltransferase 10 (NAT10) was reported to be associated with the immune microenvironment in several cancers. However, it is not known in pancreatic ductal adenocarcinoma (PDAC). This study aimed to elucidate the roles and mechanisms of NAT10 in tumor malignancy and the tumor microenvironment (TME) in PDAC.
Enhong Chen, Qin Wang, Leisheng Wang, Zebo Huang, Dongjie Yang, Changyong Zhao, Wuqiang Chen, Shuo Zhang, Shuming Xiong, Youzhao He, Yong Mao, Hao Hu   +11 more
wiley   +1 more source

A dependent pathway of cytoplasmic polyadenylation reactions linked to cell cycle control by c-mos and CDK1 activation. [PDF]

, 1997
Scott Ballantyne, D. Daniel, Marvin Wickens   +2 more
openalex   +1 more source

Macromolecular High‐Affinity Binding Probed by Advanced Fluorescence Techniques

ChemBioChem, EarlyView.
For interacting biomolecules in solution, confocal fluorescence microscopy enables some very effective approaches to characterize intermolecular binding in complex sample environments and with small sample consumption. These approaches range from fluorescence‐based genetically encoded biosensors for use in living cells to the high controllability in ...
Alida Meyer, Benno Schedler, Jörg Fitter   +2 more
wiley   +1 more source