Results 171 to 180 of about 69,053 (332)

Selective modulation of the cyclin B/CDK1 and cyclin D/CDK4 complexes during in vitro human megakaryocyte development [PDF]

, 1999
Alessandra Bassini, Sabina Pierpaoli, Elisabetta Falcieri, Marco Vitale, Lia Guidotti, Silvano Capitani, Giorgio Zauli   +6 more
openalex   +1 more source

MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling

Journal of Cell Biology, 2019
Cyclin B–dependent kinase (CDK1-CCNB1) promotes entry into mitosis. Additionally, it inhibits mitotic exit by activating the spindle checkpoint. This latter role is mediated through phosphorylation of the checkpoint kinase MPS1 and other spindle ...
Tatiana Alfonso-Pérez, D. Hayward, James Holder, U. Gruneberg, F. Barr   +4 more
semanticscholar   +1 more source

Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly

Cytoskeleton, EarlyView.
ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley   +1 more source

Structural basis of human separase regulation by securin and CDK1–cyclin B1

Nature, 2021
Jun Yu, P. Raia, C. M. Ghent, T. Raisch, Y. Sadian, S. Cavadini, Pramod M. Sabale, D. Barford, S. Raunser, D. Morgan, A. Boland   +10 more
semanticscholar   +1 more source

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

Developmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore, Anjali Balakrishnan, Yacine Touahri, Dawn Zinyk, Humna Noman, Satoshi Okawa, Jeff Biernaskie, Carol Schuurmans   +7 more
wiley   +1 more source

Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo [PDF]

, 2001
Anne C. Østvold, Jens Henrik Norum, Siri B.W Mathiesen, Birgit Wanvik, Iren Sefland, Kirsten Grundt   +5 more
openalex   +1 more source

WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells

Proceedings of the National Academy of Sciences of the United States of America, 2019
WEE1 kinase is a key regulator of the G2/M transition. The WEE1 kinase inhibitor AZD1775 (WEE1i) induces origin firing in replicating cells. We show that WEE1i induces CDK1-dependent RIF1 phosphorylation and CDK2- and CDC7-dependent activation of the ...
T. Moiseeva, Chenao Qian, Norie Sugitani, H. Osmanbeyoglu, C. Bakkenist   +4 more
semanticscholar   +1 more source

Bioinformatics analysis of immune‐programmed cell death‐related genes in nasopharyngeal carcinoma

Eye &ENT Research, EarlyView.
Abstract Background Nasopharyngeal carcinoma (NPC) is a prevalent malignant tumor of the head and neck, characterized by a complex pathogenesis. Most newly diagnosed NPC patients are locally advanced, and 20%–30% of advanced NPC patients have poor immunotherapy results.
Hongqiang Chen, Zhe Zhang, Xueting Yang, Chao Li   +3 more
wiley   +1 more source

Cdk1, Plks, Auroras, and Neks: The Mitotic Bodyguards

, 2008
“omnis cellula e cellula”, in 1858, an important dogma in cell biology was born, when Rudolf Virchow established that every cell must derives from a pre-existing cell. And indeed cell division is the only way for life to expend, it is also the way for immortalization, and unfortunately when uncontrolled also the way for cancer.
Salaün, Patrick, Rannou, Yoann, Prigent, Claude   +2 more
openaire   +5 more sources

Prognostic Significance of CDK1 in Ovarian and Cervical Cancers. [PDF]

J Cancer
Background: Ovarian cancer (OC) and cervical cancer (CC) are the leading causes of death among women. Therefore, identifying markers for early detection and treatment is critical. CDK1 governs the G2/M transition of the cell cycle and is a significant regulatory protein of the cycle.
Xu C, Chen C, Xu Y, Li Z, Chen H, Wang G.   +5 more
europepmc   +3 more sources