Results 171 to 180 of about 67,859 (329)
Bioscience Reports, 2019 Overexpressed genes in tumors usually contributed to aggressiveness in pancreatic ductal adenocarcinoma (PDAC). Using Gene Expression Omnibus (GEO) profiles including GSE46234, GSE71989, and GSE107610, we detected overexpressed genes in tumors with R ...
Shu Dong +3 more
semanticscholar +1 more source
Aging Cell, EarlyView.The underlying mechanisms of age‐related revascularization impairment are not clear. Our research firstly identified that macrophages were more senescent in the ischemic skeletal muscle of old mice and senescent macrophages could inhibit revascularization.
Minghong Chen +7 more
wiley +1 more source
CDK1 Inactivation Regulates Anaphase Spindle Dynamics and Cytokinesis In Vivo [PDF]
, 1997 Sally P. Wheatley +5 more
openalex +1 more source
Partial inhibition of Cdk1 in G2 phase overrides the SAC and decouples mitotic events
Cell Cycle, 2014 Entry and progression through mitosis has traditionally been linked directly to the activity of cyclin-dependent kinase 1 (Cdk1). In this study we utilized low doses of the Cdk1-specific inhibitor, RO3306 from early G2 phase onwards.
R. McCloy +5 more
semanticscholar +1 more source
A Mathematical Model of the Cell Cycle: Exploring the Impact of Zingerone on Cancer Cell Proliferation [PDF]
arXivThis paper presents a mathematical model that explores the interactions between Cyclin-Dependent Kinase 1 (CDK1) and the Anaphase-Promoting Complex (APC) in cancer cells. Through the analysis of a dynamical system simulating the CDK1-APC network, we investigate the system's behavior and its implications for cancer progression and potential therapeutic ...
arxiv
Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration
Aging Cell, EarlyView.Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Jonathan Plessis‐Belair +3 more
wiley +1 more source
CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours
PLOS ONE, 2016 Activating KRAS mutations are found in approximately 20% of human cancers but no RAS-directed therapies are currently available. Here we describe a novel, robust, KRAS synthetic lethal interaction with the cyclin dependent kinase, CDK1. This was discovered using parallel siRNA screens in KRAS mutant and wild type colorectal isogenic tumour cells and ...
Costa-Cabral, S +10 more
openaire +8 more sources
A dependent pathway of cytoplasmic polyadenylation reactions linked to cell cycle control by c-mos and CDK1 activation. [PDF]
, 1997 Scott Ballantyne +2 more
openalex +1 more source
MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling
Journal of Cell Biology, 2019 Cyclin B–dependent kinase (CDK1-CCNB1) promotes entry into mitosis. Additionally, it inhibits mitotic exit by activating the spindle checkpoint. This latter role is mediated through phosphorylation of the checkpoint kinase MPS1 and other spindle ...
Tatiana Alfonso-Pérez +4 more
semanticscholar +1 more source
Cancer Science, EarlyView.PSMD14/E2F1 axis‐mediated CENPF could promote the metastasis of BC through inhibiting arachidonic acid metabolism‐induced ferroptosis. This research might bring novel insights on discovering methods in alleviating tumor metastasis in BC. ABSTRACT The metastasis of triple‐negative breast cancer (TNBC) usually contributes to the failure of treatment ...
Meifeng Zhou +4 more
wiley +1 more source