Results 221 to 230 of about 67,859 (329)

Regulation of Activation-induced Fas (CD95/Apo-1) Ligand Expression in T Cells by the Cyclin B1/Cdk1 Complex [PDF]

, 2004
Ralph Torgler, Sabine Jakob, Edgar Ontsouka, Ueli Nachbur, Christoph Mueller, Douglas R. Green, Thomas Brunner   +6 more
openalex   +1 more source

Isoliquiritigenin Promotes the Repair of High Uric Acid‐Induced Vascular Injuries

Smart Medicine, Volume 4, Issue 2, June 2025.
High uric acid‐induced vascular injuries are always accompanied with hyperuricemia, for which seeking for effective safety drugs is an urgent and crucial problem that needs to be solved. Here, we have successfully screened isoliquiritigenin out from multiplex traditional Chinese medicine monomers in promoting the repair of high uric acid‐induced ...
Hongyan Zhou, Xinyu Song, Yingying Tian, Lili Zhao, Jingyi Yang, Fangfu Ye, Ting Cao, Jiayu Zhang   +7 more
wiley   +1 more source

GGCT Inhibits Ferroptosis in PTC Cells by Upregulating p53 Through RPS15A

Cancer Science, Volume 116, Issue 6, Page 1592-1603, June 2025.
Our results showed that γ‐glutamine cyclotransferase (GGCT) knockdown in PTC cells inhibited GSH synthesis, promoted the malignant accumulation of malondialdehyde (MDA) and reactive oxygen species (ROS), and finally promoted cell ferroptosis. In vivo experiments showed that Pro‐GA, a specific inhibitor of GGCT, inhibited the subcutaneous tumorigenesis ...
Hui‐min Zhang, Han‐ning Li, Enbo Qi, Yang Yang, Huiping Ma, Jie Ma, Xiwen Xiong, Jun Wang, Zhi‐fang Yang, Xing‐hua Liao   +9 more
wiley   +1 more source

Optimization of Immunotherapy Strategies Based on Spatiotemporal Heterogeneity of Tumour‐Associated Tissue‐Resident Memory T Cells

Immunology, Volume 175, Issue 2, Page 123-133, June 2025.
The tumour microenvironment (TME) and tumour evolution stage lead to temporal and spatial heterogeneity in tumour‐resident macrophages (TRMs), affecting their phenotype and function across different stages and tumour types. While TRMs infiltration is often linked to positive immunotherapy responses and prognosis, some subtypes may negatively impact ...
Yile Shang, Yinjun He, Xiang Zhang, Wenguang He, Hanju Hua, Feng Ye, Xile Zhou, Yandong Li, Weixiang Zhong, Guosheng Wu, Weiqin Jiang   +10 more
wiley   +1 more source

Identification of differentially expressed genes in oral squamous cell carcinoma (OSCC): Overexpression of NPM, CDK1 and NDRG1 and underexpression of CHES1 [PDF]

, 2005
Joseph Tung‐Chieh Chang, Hung‐Ming Wang, K.Y. Chang, Wen‐Ho Chen, Mingchun Wen, Yuan‐Ming Hsu, Benjamin Yat‐Ming Yung, I‐How Chen, Chun‐Ta Liao, Ling–Ling Hsieh, Ann‐Joy Cheng   +10 more
openalex   +1 more source

The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers [PDF]

, 2006
Michelle T. Paulsen, Adrienne M. Starks, Frederick A. Derheimer, Sheela Hanasoge, Liwu Li, Jack E. Dixon, Mats Ljungman   +6 more
openalex   +3 more sources

Omaveloxolone Suppresses Cell Growth and Causes Cell Cycle Arrest by Downregulating CDC20 Expression in Glioblastoma Cells Both In Vitro and In Vivo

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Omaveloxolone is a synthetic oleanane triterpene with considerable antitumor activity. It induces human glioblastoma (GBM) cell death in vitro and in vivo, but the underlying mechanism remains to be determined. In this study, GBM cell lines (GBM8401 and U‐87 MG cells) were exposed to different concentrations of omaveloxolone (0, 600, 800 and ...
Kuan‐Ting Lee, Yi‐Chiang Hsu, Ann‐Shung Lieu, Chih‐Lung Lin, Tai‐Hsin Tsai   +4 more
wiley   +1 more source

Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling [PDF]

, 2005
Christian Preisinger, Roman Körner, Mathias Wind, Wolf D. Lehmann, Robert Kopajtich, Francis A. Barr   +5 more
openalex   +1 more source

HAND2-AS1 plays a tumor-suppressive role in hepatoblastoma through the negative regulation of CDK1

Heliyon
Objective: Hepatoblastoma (HB) is the most commonly seen pediatric liver malignancy. The preliminary experiment of our research group found that cyclin dependent kinase 1 (CDK1) was upregulated in HB.
Keke Chen, Yalan You, Wenfang Tang, Xin Tian, Chengguang Zhu, Zexi Yin, Minhui Zeng, Xiangling He   +7 more
doaj  

The Efficacy of Hellebrigenin Against Nasopharyngeal Carcinoma Cells: The Molecular and Bioinformatic Analysis

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Nasopharyngeal carcinoma (NPC) is a unique cancer type originating from the nasopharynx. To investigate novel strategies for improving prognosis and reducing the adverse effects of current treatments, this study examined the efficacy of hellebrigenin.
Hsin‐Yu Ho, Mu‐Kuan Chen, Yun‐Jung Tsai, Chia‐Chieh Lin, Yu‐Sheng Lo, Yi‐Ching Chuang, Ming‐Ju Hsieh   +6 more
wiley   +1 more source