Role of caspases, calpain and cdk5 in ammonia-induced cell death in developing brain cells [PDF]
Neurobiology of Disease, 2008 Hyperammonemia in neonates and infants causes irreversible damages in the developing CNS due to brain cell loss. Elucidating the mechanisms triggering ammonia-induced cell death in CNS is necessary for the development of neuroprotective strategies.
Laurène Cagnon, Olivier Braissant
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The Duality of Cdk5: A Master Regulator in Neurodevelopment and a Hijacked Oncogene in Cancer [PDF]
CellsCyclin-dependent kinase 5 (Cdk5) is an atypical serine/threonine kinase distinct from classical cell cycle regulators. Its activity is highest in the nervous system and essential for development, but its functions in other tissues, particularly in cancer,
Yoshiaki V. Nishimura, Takeshi Kawauchi
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Targeting a Tau Kinase Cdk5, Cyclin-Dependent Kinase: A Blood-Based Diagnostic Marker and Therapeutic Earmark for Alzheimer’s Disease [PDF]
BiomoleculesProtein kinases are important molecules of Alzheimer’s Disease (AD), driving neuronal demise and the emergence of the disease’s destructive hallmarks. Cdk5 has recently been highlighted as a key therapeutic target for AD.
Sakshi Kumari +9 more
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Inhibition of CDK5 signaling mediated inflammation in macrophages promotes cutaneous wound healing [PDF]
Scientific ReportsCyclin-dependent kinase 5 (CDK5) plays a critical role in the inflammatory response. Macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair.
Jingjing Wang +12 more
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All-Trans Retinoic Acid Induces DU145 Cell Cycle Arrest through Cdk5 Activation [PDF]
Cellular Physiology and Biochemistry, 2014 Background/Aims: All-trans retinoic acid (ATRA), the active form of vitamin A, plays an important role in the growth arrest of numerous types of cancer cells.
Eugene Lin +7 more
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Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors. [PDF]
, 2013 Current inhibitors of angiogenesis comprise either therapeutic antibodies (e.g. bevacicumab binding to VEGF-A) or small molecular inhibitors of receptor tyrosin kinases like e.g. sunitinib, which inhibits PDGFR and VEGFR.
Fürst, Robert +8 more
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Cells, 2021 Cyclin-dependent kinase 5 (Cdk5) is expressed in terminally differentiated cells, where it drives development, morphogenesis, and survival. Temporal and spatial kinase activity is regulated by specific activators of Cdk5, dependent on the cell type and ...
Nicole Mangold +9 more
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Open Chemistry, 2021 Pit-1 (POU1F1) is a POU-homeodomain transcription factor, and it is one of the most important tissue-specific transcription factors in pituitary development.
Xie Weiyan +5 more
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CDK5: an oncogene or an anti-oncogene: location location location
Molecular Cancer, 2023 Recent studies have uncovered various physiological functions of CDK5 in many nonneuronal tissues. Upregulation of CDK5 and/or its activator p35 in neurons promotes healthy neuronal functions, but their overexpression in nonneuronal tissues is causally ...
Kumar Nikhil, Kavita Shah
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Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior
Frontiers in Pharmacology, 2022 Cyclin-dependent kinase 5 (Cdk5) is a crucial regulator of neuronal signal transduction. Cdk5 activity is implicated in various neuropsychiatric and neurodegenerative conditions such as stress, anxiety, depression, addiction, Alzheimer’s disease, and ...
Alan Umfress +11 more
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