The Duality of Cdk5: A Master Regulator in Neurodevelopment and a Hijacked Oncogene in Cancer [PDF]
CellsCyclin-dependent kinase 5 (Cdk5) is an atypical serine/threonine kinase distinct from classical cell cycle regulators. Its activity is highest in the nervous system and essential for development, but its functions in other tissues, particularly in cancer,
Yoshiaki V. Nishimura, Takeshi Kawauchi
doaj +2 more sources
Targeting a Tau Kinase Cdk5, Cyclin-Dependent Kinase: A Blood-Based Diagnostic Marker and Therapeutic Earmark for Alzheimer’s Disease [PDF]
BiomoleculesProtein kinases are important molecules of Alzheimer’s Disease (AD), driving neuronal demise and the emergence of the disease’s destructive hallmarks. Cdk5 has recently been highlighted as a key therapeutic target for AD.
Sakshi Kumari +9 more
doaj +2 more sources
HPV18E6 and CDK5 virus-host interaction is a prospective therapeutic target for HPV-positive cervical cancer [PDF]
Tumour Virus ResearchThe E6 oncoprotein encoded by the cancer-causing human papillomavirus (HPV) is vital for maintaining the ability of the virus to promote cell proliferation and cancer progression.
Chuanyun Xiao +4 more
doaj +2 more sources
Inhibition of CDK5 signaling mediated inflammation in macrophages promotes cutaneous wound healing [PDF]
Scientific ReportsCyclin-dependent kinase 5 (CDK5) plays a critical role in the inflammatory response. Macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair.
Jingjing Wang +12 more
doaj +2 more sources
Cells, 2021 Cyclin-dependent kinase 5 (Cdk5) is expressed in terminally differentiated cells, where it drives development, morphogenesis, and survival. Temporal and spatial kinase activity is regulated by specific activators of Cdk5, dependent on the cell type and ...
Nicole Mangold +9 more
doaj +1 more source
Open Chemistry, 2021 Pit-1 (POU1F1) is a POU-homeodomain transcription factor, and it is one of the most important tissue-specific transcription factors in pituitary development.
Xie Weiyan +5 more
doaj +1 more source
CDK5: an oncogene or an anti-oncogene: location location location
Molecular Cancer, 2023 Recent studies have uncovered various physiological functions of CDK5 in many nonneuronal tissues. Upregulation of CDK5 and/or its activator p35 in neurons promotes healthy neuronal functions, but their overexpression in nonneuronal tissues is causally ...
Kumar Nikhil, Kavita Shah
doaj +1 more source
ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity. [PDF]
PLoS ONE, 2014 Cyclin-dependent kinase 5 is a proline-directed serine/threonine kinase and its activity participates in the regulation of nociceptive signaling. Like binding with the activators (P35 or P25), the phosphorylation of Cdk5 plays a critical role in Cdk5 ...
Xiaoqin Zhang +4 more
doaj +1 more source
Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior
Frontiers in Pharmacology, 2022 Cyclin-dependent kinase 5 (Cdk5) is a crucial regulator of neuronal signal transduction. Cdk5 activity is implicated in various neuropsychiatric and neurodegenerative conditions such as stress, anxiety, depression, addiction, Alzheimer’s disease, and ...
Alan Umfress +11 more
doaj +1 more source
CDK5 positively regulates Notch1 signaling in pancreatic cancer cells by phosphorylation
Cancer Medicine, 2021 The marked overexpression of cyclin‐dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. Although, a previous study has
Qiaoyun Chu +4 more
doaj +1 more source