Results 11 to 20 of about 28,778 (201)
Biological functions of CDK5 and potential CDK5 targeted clinical treatments. [PDF]
Oncotarget, 2017 Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit.
Casimiro, Mathew C. +2 more
core +4 more sources
Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis. [PDF]
PLoS ONE, 2016 Podocytes are terminally differentiated glomerular epithelial cells. Podocyte loss has been found in many renal diseases. Cdk5 is a cyclin-dependent protein kinase which is predominantly regulated by p35.
Ya-Li Zheng +11 more
doaj +4 more sources
Journal of Biomedical Science, 2021 AbstractCdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function. The mechanisms underlying the modulation of Cdk5, its modes of action, and its effects on the nervous system have been a great focus in the field for nearly three ...
Pao, Ping-Chieh, Tsai, Li-Huei
openaire +4 more sources
Structural Insights into Cdk5 Activation by a Neuronal Cdk5 Activator [PDF]
Biochemical and Biophysical Research Communications, 2001 Although Cdk5 shows high sequence identity to Cdk1 and Cdk2, it can be fully activated by its neuronal activators p35/p25(nck5a) and p39(nck5ai) in a phosphorylation-independent manner. To understand structural basis of the Cdk5/p25(nck5a) activation, the complex is modelled to assume either an obstructed or an opened conformation based on X-ray ...
Lim, HY +5 more
+12 more sources
ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity. [PDF]
PLoS ONE, 2014 Cyclin-dependent kinase 5 is a proline-directed serine/threonine kinase and its activity participates in the regulation of nociceptive signaling. Like binding with the activators (P35 or P25), the phosphorylation of Cdk5 plays a critical role in Cdk5 ...
Xiaoqin Zhang +4 more
doaj +1 more source
CDK5 positively regulates Notch1 signaling in pancreatic cancer cells by phosphorylation
Cancer Medicine, 2021 The marked overexpression of cyclin‐dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. Although, a previous study has
Qiaoyun Chu +4 more
doaj +1 more source
PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPAR?? at Ser273 [PDF]
, 2020 Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPAR gamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK ...
Choi, Jang Hyun +11 more
core +1 more source
Cdk5 variant 1 (cdk5-v1), but not full-length cdk5, is a centrosomal protein [PDF]
Cell Cycle, 2010 (2010). Cdk5 variant 1 (cdk5-v1), but not full-length cdk5, is a centrosomal protein. Cell Cycle: Vol. 9, No. 11, pp. 2251-2253.
Tom, Kim +3 more
openaire +2 more sources
Cdk5 regulates Rap1 activity [PDF]
Neurochemistry International, 2013 Rap1 signaling is important for migration, differentiation, axonal growth, and during neuronal polarity. Rap1 can be activated by external stimuli, which in turn regulates specific guanine nucleotide exchange factors such as C3G, among others. Cdk5 functions are also important to neuronal migration and differentiation.
Utreras Puratich, Elías +7 more
openaire +11 more sources