Results 11 to 20 of about 14,231 (159)
Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis. [PDF]
PLoS ONE, 2016 Podocytes are terminally differentiated glomerular epithelial cells. Podocyte loss has been found in many renal diseases. Cdk5 is a cyclin-dependent protein kinase which is predominantly regulated by p35.
Ya-Li Zheng +11 more
doaj +4 more sources
Journal of Biomedical Science, 2021 AbstractCdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function. The mechanisms underlying the modulation of Cdk5, its modes of action, and its effects on the nervous system have been a great focus in the field for nearly three ...
Pao, Ping-Chieh, Tsai, Li-Huei
openaire +4 more sources
Structural Insights into Cdk5 Activation by a Neuronal Cdk5 Activator [PDF]
Biochemical and Biophysical Research Communications, 2001 Although Cdk5 shows high sequence identity to Cdk1 and Cdk2, it can be fully activated by its neuronal activators p35/p25(nck5a) and p39(nck5ai) in a phosphorylation-independent manner. To understand structural basis of the Cdk5/p25(nck5a) activation, the complex is modelled to assume either an obstructed or an opened conformation based on X-ray ...
Lim, HY +5 more
+12 more sources
Cdk5 variant 1 (cdk5-v1), but not full-length cdk5, is a centrosomal protein [PDF]
Cell Cycle, 2010 (2010). Cdk5 variant 1 (cdk5-v1), but not full-length cdk5, is a centrosomal protein. Cell Cycle: Vol. 9, No. 11, pp. 2251-2253.
Tom, Kim +3 more
openaire +2 more sources
Cdk5 regulates Rap1 activity [PDF]
Neurochemistry International, 2013 Rap1 signaling is important for migration, differentiation, axonal growth, and during neuronal polarity. Rap1 can be activated by external stimuli, which in turn regulates specific guanine nucleotide exchange factors such as C3G, among others. Cdk5 functions are also important to neuronal migration and differentiation.
Utreras Puratich, Elías +7 more
openaire +11 more sources
Role of caspases, calpain and cdk5 in ammonia-induced cell death in developing brain cells
Neurobiology of Disease, 2008 Hyperammonemia in neonates and infants causes irreversible damages in the developing CNS due to brain cell loss. Elucidating the mechanisms triggering ammonia-induced cell death in CNS is necessary for the development of neuroprotective strategies.
Laurène Cagnon, Olivier Braissant
doaj +1 more source
CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis
Journal of Experimental & Clinical Cancer Research, 2019 Background CDK5, an atypical member of the CDK family, play a significant role in the tumorigenesis of multiple organ, but CDK5 and its substrates in genesis and development of HCC is still unclear.
Fuqiang Wang +10 more
doaj +1 more source
Regulation of Sox6 by cyclin dependent kinase 5 in brain. [PDF]
PLoS ONE, 2014 Cyclin dependent kinase 5 (Cdk5) is a proline-directed Ser/Thr kinase involved in various biological functions during normal brain development and neurodegeneration.
Parvathi Rudrabhatla +3 more
doaj +1 more source
生物医学转化, 2022 Objective This study aims to elucidate the underlying mechanism of hyperglycemia induced Alzheimer's disease (AD)-like pathological changes. Methods Thirty Sprague Dawley rats (aged 18 weeks) were randomly divided into one control groups and two ...
Cai Hongbin +7 more
doaj +1 more source