Results 21 to 30 of about 28,778 (201)
CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis
Journal of Experimental & Clinical Cancer Research, 2019 Background CDK5, an atypical member of the CDK family, play a significant role in the tumorigenesis of multiple organ, but CDK5 and its substrates in genesis and development of HCC is still unclear.
Fuqiang Wang +10 more
doaj +1 more source
Regulation of Sox6 by cyclin dependent kinase 5 in brain. [PDF]
PLoS ONE, 2014 Cyclin dependent kinase 5 (Cdk5) is a proline-directed Ser/Thr kinase involved in various biological functions during normal brain development and neurodegeneration.
Parvathi Rudrabhatla +3 more
doaj +1 more source
生物医学转化, 2022 Objective This study aims to elucidate the underlying mechanism of hyperglycemia induced Alzheimer's disease (AD)-like pathological changes. Methods Thirty Sprague Dawley rats (aged 18 weeks) were randomly divided into one control groups and two ...
Cai Hongbin +7 more
doaj +1 more source
A kinase of many talents: non-neuronal functions of CDK5 in development and disease [PDF]
Open Biology, 2020 The cyclin-dependent kinase 5 (CDK5) represents an unusual member of the family of cyclin-dependent kinases, which is activated upon binding to non-cyclin p35 and p39 proteins. The role of CDK5 in the nervous system has been very well established.
Samanta Sharma, Piotr Sicinski
doaj +1 more source
p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]
, 2005 In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Bertrand, Philippe +7 more
core +1 more source
Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia. [PDF]
PLoS ONE, 2013 Cyclin-dependent kinase-5 (Cdk5) is over-expressed in both neurons and microvessels in hypoxic regions of stroke tissue and has a significant pathological role following hyper-phosphorylation leading to calpain-induced cell death.
Alessandra Bosutti +17 more
doaj +1 more source
Cdk5 activity in the brain - multiple paths of regulation [PDF]
, 2014 Cyclin dependent kinase-5 (Cdk5), a family member of the cyclin-dependent kinases, plays a pivotal role in the central nervous system. During embryogenesis, Cdk5 is indispensable for brain development and, in the adult brain, it is essential for numerous
Lahiri, Debomoy, Shah, Kavita
core +1 more source
Cdk5, the multifunctional surveyor [PDF]
Cell Cycle, 2010 Cyclin-dependent kinases (Cdks) are a family of proline-directed Ser/Thr kinases known for their role in the control of cell cycle progression. In 1992, this family was joined by Cdk5, which is an atypical member in that it uses its own activators and is multifunctional, playing important regulatory roles in multiple cellular functions. Here, we review
Vassiliki, Lalioti +2 more
openaire +2 more sources
Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]
, 2009 The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
core +1 more source
Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals [PDF]
, 2012 Presynaptic terminals are specialized sites for information transmission where vesicles fuse with the plasma membrane and are locally recycled. Recent work has extended this classical view, with the observation that a subset of functional vesicles is ...
Burden, Jemima J +8 more
core +1 more source