Results 21 to 30 of about 14,231 (159)
Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia. [PDF]
PLoS ONE, 2013 Cyclin-dependent kinase-5 (Cdk5) is over-expressed in both neurons and microvessels in hypoxic regions of stroke tissue and has a significant pathological role following hyper-phosphorylation leading to calpain-induced cell death.
Alessandra Bosutti +17 more
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A kinase of many talents: non-neuronal functions of CDK5 in development and disease [PDF]
Open Biology, 2020 The cyclin-dependent kinase 5 (CDK5) represents an unusual member of the family of cyclin-dependent kinases, which is activated upon binding to non-cyclin p35 and p39 proteins. The role of CDK5 in the nervous system has been very well established.
Samanta Sharma, Piotr Sicinski
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Cdk5, the multifunctional surveyor [PDF]
Cell Cycle, 2010 Cyclin-dependent kinases (Cdks) are a family of proline-directed Ser/Thr kinases known for their role in the control of cell cycle progression. In 1992, this family was joined by Cdk5, which is an atypical member in that it uses its own activators and is multifunctional, playing important regulatory roles in multiple cellular functions. Here, we review
Vassiliki, Lalioti +2 more
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Active Cdk5 Immunoprecipitation and Kinase Assay
Bio-Protocol, 2017 Cdk5 activity is regulated by the amounts of two activator proteins, p35 and p39 (Tsai et al., 1994; Zheng et al., 1998; Humbert et al., 2000). The p35-Cdk5 and p39-Cdk5 complexes have differing sensitivity to salt and detergent concentrations (Hisanaga ...
Andrew Bankston, Li Ku, Yue Feng
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A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes
Proceedings of the National Academy of Sciences, 2023 Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various neurodegenerative diseases. This deleterious effect is mediated by pathological cleavage of the Cdk5 activator p35 into the truncated product p25, leading to prolonged Cdk5 activation and altered substrate specificity. Elevated p25 levels have been reported in humans and
Ping-Chieh Pao +17 more
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The Structural Perspective on CDK5 [PDF]
Neurosignals, 2003 Cyclin-dependent kinase 5 (CDK5) plays an essential role in the development of the central nervous system during mammalian embryogenesis. In the adult, CDK5 is required for the maintenance of neuronal architecture. Its deregulation has profound cytotoxic effects and has been implicated in the development of neurodegenerative diseases such as Alzheimer ...
Mapelli, Marina, Musacchio, Andrea
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Cancer Cell International, 2019 Background Bridging integrator 1 (BIN1) has showed outstanding tumor-suppressive potential via inhibiting c-MYC-mediated tumorigenesis. However, a frequent phosphorylation of c-MYC at Ser-62 site could block the BIN1/c-MYC interaction and limits the ...
Xiangyu Zhang +8 more
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Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5.
PLoS ONE, 2009 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that has been implicated in learning, synaptic plasticity, neurotransmission, and numerous neurological disorders.
Ammar H Hawasli +7 more
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Inactivation of Cyclin-Dependent Kinase 5 in Hair Cells Causes Hearing Loss in Mice
Frontiers in Molecular Neuroscience, 2018 Cyclin-dependent kinase 5 (CDK5) is abundantly expressed in post-mitotic cells including neurons. It is involved in multiple cellular events, such as cytoskeletal dynamics, signaling cascades, gene expression, and cell survival, et al.
Xiaoyan Zhai +7 more
doaj +1 more source
CDK5 activator p35 downregulates E‐cadherin precursor independently of CDK5
FEBS Letters, 2008 Dysfunction of E-cadherins often results in metastasis of cancerous cells. Here we show that p35, a critical regulator of cyclin-dependent kinase 5 (CDK5), specifically depletes the precursor form of E-cadherin, but not the mature form, by using a precursor-specific antibody.
Lin, Shuyong +4 more
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