Results 181 to 190 of about 246,652 (211)

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Single cell Raman spectroscopic profiles predict treatment responses in patients with <i>de novo</i> acute myeloid leukemia. [PDF]

Front Cell Dev Biol
Zhang M, Su L, Han W, Song F, Fu Y, Chi MB, Chen X, Wu YH, Gao SJ.   +8 more
europepmc   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Programmable Hierarchical Assembly of Atomically Precise Metal Nanoclusters Using Supra-Amphiphilic Nucleic Acids. [PDF]

JACS Au
Zhou G, Zhang S, Zhou Y, Yan B, Duan M, Zheng H, Zhou L, Luo S, Shen J.   +8 more
europepmc   +1 more source

Membrane-Spanning Nanopores Formed from Nucleic Acids. [PDF]

Chem Rev
Li Y, Karrasch T, Keyser UF, Göpfrich K.   +3 more
europepmc   +1 more source

Detection of a Target Nucleic Acid by Ligation-Assisted Fluorescence Enhancement of a Peptide Nucleic Acid (PNA) Twin Probe via Disulfide Binding. [PDF]

Biopolymers
Ouchi Y, Ishii K, Sato Y, Imai Y, Matsui H, Ohtsuki T, Hakata Y, Shigeto H, Yamamura S, Kitamatsu M.   +9 more
europepmc   +1 more source

Z-nucleic acid-mediated PANoptosis in infection, inflammation, and cancer. [PDF]

Commun Biol
Thapa N, Kim A, Patel P, Nguyen MQ, Lee E, Karki R.   +5 more
europepmc   +1 more source

Low-toxic and organic solvent-free isolation of RNA. [PDF]

PLoS One
Böttcher R, Fröhlich T, Förstemann K.
europepmc   +1 more source

Revealing the biomolecular response of glioma cells to helium, carbon and oxygen minibeam radiation therapy using synchrotron-based infrared microspectroscopy.

Analyst
González-Vegas R, Seksek O, Chiblak S, Brons S, Abdollahi A, Prezado Y, Yousef I, Martínez-Rovira I.   +7 more
europepmc   +1 more source