Results 41 to 50 of about 9,966,852 (260)
Engineering cell free protein synthesis and synthetic cells [PDF]
, 2023 Mimicking the structure and function of natural cells, synthetic cells hold significant potential in various applications. These synthetic cells, which come in numerous forms, are developed from different materials, including lipids and proteins, as well
Chowdhry, Razia
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Protocols for Implementing an Escherichia coli Based TX-TL Cell-Free Expression System for Synthetic Biology [PDF]
, 2013 Ideal cell-free expression systems can theoretically emulate an in vivo cellular environment in a controlled in vitro platform. This is useful for expressing proteins and genetic circuits in a controlled manner as well as for providing a prototyping ...
Sun, Zachary Z. +5 more
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Holistic engineering of cell-free systems through proteome-reprogramming synthetic circuits
Nature Communications, 2020 Synthetic biological modules can be used to reprogram host proteomes, which in turn enhance the function of the synthetic modules. The authors use this holistic synthetic biology approach to engineer a more favorable environment for cell-free protein ...
Luis E. Contreras-Llano +6 more
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Immuno, 2021 Improvements in bioengineering methodology and tools have allowed for significant progress in the development of therapeutics and diagnostics in medicine, as well as progress in many other diverse industries, such as materials manufacturing, food and ...
Leila A. Mashouf +4 more
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, 2009 There is currently much excitement surrounding the rapidly growing discipline of synthetic biology, which utilizes the design and construction principles of engineering to develop, evolve and standardize biological components and systems. This systematic
Ali Tavassoli, Tavassoli, Ali
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Synthetic Biology Outside the Cell: Linking Computational Tools to Cell-Free Systems
Frontiers in Bioengineering and Biotechnology, 2014 As mathematical models become more commonly integrated into the study of biology, a common language for describing biological processes is manifesting. Many tools have emerged for the simulation of in vivo systems, with only a few examples of prominent ...
Daniel eLewis +3 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Uptake of synthetic low density lipoprotein by leukemic stem cells — a potential stem cell targeted drug delivery strategy [PDF]
, 2010 Chronic Myeloid Leukemia (CML) stem/progenitor cells, which over-express Bcr-Abl, respond to imatinib by a reversible block in proliferation without significant apoptosis.
Jørgensen, Heather G. +25 more
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Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics
, 2021 © 2021 Elsevier Inc. Synthetic biology is a design-driven discipline centered on engineering novel biological functions through the discovery, characterization, and repurposing of molecular parts.
Justin H. Letendre +7 more
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