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Cell-Penetrating Peptides and Transportan [PDF]
Pharmaceutics, 2021 In the most recent 25–30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems.
Ülo Langel
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Internalization mechanisms of cell-penetrating peptides [PDF]
Beilstein Journal of Nanotechnology, 2020 In today’s modern era of medicine, macromolecular compounds such as proteins, peptides and nucleic acids are dethroning small molecules as leading therapeutics. Given their immense potential, they are highly sought after.
Ivana Ruseska, Andreas Zimmer
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Selective Moonlighting Cell-Penetrating Peptides [PDF]
Pharmaceutics, 2021 Cell penetrating peptides (CPPs) are molecules capable of passing through biological membranes. This capacity has been used to deliver impermeable molecules into cells, such as drugs and DNA probes, among others.
Rafael Morán-Torres +5 more
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Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System
Pharmaceutics, 2022 Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of compounds into cells. Since the discovery of the first members of this peptide family, many other peptides have been identified; nowadays, dozens of these peptides ...
Ildikó Szabó +5 more
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Cell-Penetrating Peptides for Antiviral Drug Development [PDF]
Pharmaceuticals, 2010 Viral diseases affect hundreds of millions of people worldwide, and the few available drugs to treat these diseases often come with limitations. The key obstacle to the development of new antiviral agents is their delivery into infected cells in vivo ...
Lee W. Riley, Melaine Delcroix
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Cell Penetrating Peptides, Novel Vectors for Gene Therapy
Pharmaceutics, 2020 Cell penetrating peptides (CPPs), also known as protein transduction domains (PTDs), first identified ~25 years ago, are small, 6−30 amino acid long, synthetic, or naturally occurring peptides, able to carry variety of cargoes across the cellular ...
Rebecca E. Taylor, Maliha Zahid
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Bismuth-Cyclized Cell-Penetrating Peptides. [PDF]
Mol PharmIntracellular delivery of biological cargos, which would yield new research tools and novel therapeutics, remains an active area of research. A convenient and potentially general approach involves the conjugation of a cell-penetrating peptide to a cargo of interest. However, linear CPPs lack sufficient cytosolic entry efficiency and metabolic stability,
Ritchey JL, Filippi L, Ballard D, Pei D.
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Cell-penetrating peptides for sustainable agriculture. [PDF]
Trends Plant SciCell-penetrating peptides (CPPs) are short (typically 5-30 amino acids), cationic, amphipathic, or hydrophobic peptides that facilitate the cellular uptake of diverse cargo molecules by eukaryotic cells via direct translocation or endocytosis across the plasma membrane.
Patel P, Benzle K, Pei D, Wang GL.
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Beyond Transduction: Anti-Inflammatory Effects of Cell Penetrating Peptides [PDF]
MoleculesOne of the bottlenecks to bringing new therapies to the clinic has been a lack of vectors for delivering novel therapeutics in a targeted manner. Cell penetrating peptides (CPPs) have received a lot of attention and have been the subject of numerous ...
Jack Lopuszynski +2 more
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Conjugation of Cell-Penetrating Peptides to Antimicrobial Peptides Enhances Antibacterial Activity
ACS Omega, 2019 Antimicrobial peptides (AMPs), essential elements in host innate immune defenses against numerous pathogens, have received considerable attention as potential alternatives to conventional antibiotics. Most AMPs exert broad-spectrum antimicrobial activity
Hyunhee Lee +5 more
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