Targeting cell cycle proteins in breast cancer cells with siRNA by using lipid-substituted polyethylenimines [PDF]
Frontiers in Bioengineering and Biotechnology, 2015 The cell cycle proteins are key regulators of cell cycle progression whose de-regulation is one of the causes of breast cancer. RNA interference (RNAi) is an endogenous mechanism to regulate gene expression and it could serve as the basis of regulating ...
Manoj eParmar +6 more
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Copper Chaperone Atox1 Interacts with Cell Cycle Proteins [PDF]
Computational and Structural Biotechnology Journal, 2018 The anaphase-promoting complex (APC) is involved in several processes in the cell cycle, most prominently it facilitates the separation of the sister chromatids during mitosis, before cell division.
Maria Matson Dzebo +5 more
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Cell cycle proteins moonlight in multiciliogenesis. [PDF]
Science, 2017 Proteins that control cell cycle progression also drive multiciliated cell ...
Levine M, Holland A.
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Cell cycle proteins: Linking the cell cycle to tumors [PDF]
Oncol ResThe cell cycle is a tightly coupled series of events that enable cells to grow and proliferate. Cyclin-dependent kinases (CDKs) play crucial roles in the cell cycle by enabling cells to transition between different phases when they are activated. Cell cycle proteins enhance the activity of CDKs, while natural CDK inhibitors (CDKIs) suppress them.
ZHONG J +11 more
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A map of protein dynamics during cell-cycle progression and cell-cycle exit.
PLoS Biology, 2017 The cell-cycle field has identified the core regulators that drive the cell cycle, but we do not have a clear map of the dynamics of these regulators during cell-cycle progression versus cell-cycle exit.
Sara Gookin +7 more
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Expression of cell cycle proteins in male breast carcinoma
World Journal of Surgical Oncology, 2010 Introduction Male breast cancer (MBC) is a rare, yet potentially aggressive disease. Although literature regarding female breast cancer (FBC) is extensive, little is known about the etiopathogenesis of male breast cancer. Studies from our laboratory show
Senger Jenna-Lynn +4 more
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Cell cycle proteins as promising targets in cancer therapy. [PDF]
Nat Rev Cancer, 2017 Otto T, Sicinski P.
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Macrophages—proliferation, activation, and cell cycle proteins [PDF]
Journal of Leukocyte Biology, 1999 Abstract Our understanding of mammalian cell proliferation has increased enormously over the past decade. A major advance has been identification and characterization of cyclins and their catalytic partners, cyclin-dependent kinases (cdks).
P. Vadiveloo
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Overexpression of Cell Cycle Proteins of Peripheral Lymphocytes in Patients with Alzheimer's Disease. [PDF]
Psychiatry Investig, 2016 Objective Biological markers for Alzheimer's disease (AD) will help clinicians make objective diagnoses early during the course of dementia. Previous studies have suggested that cell cycle dysregulation begins earlier than the onset of clinical ...
Kim H +6 more
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Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer's disease. [PDF]
Acta Neuropathol, 2015 Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder for which no effective treatment is available. Increased insight into the disease mechanism in early stages of pathology is required for the development of a successful therapy ...
van Leeuwen LA, Hoozemans JJ.
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