World Journal of Surgical Oncology, 2023 Background The Forkhead box M1 factor (FOXM1) is a crucial activator for cancer cell proliferation. While FOXM1 has been shown to promote hepatocellular carcinoma (HCC) progression, its transcriptional mechanisms remain incompletely understood.
Hua-Yu Wu +3 more
doaj +1 more source
Functional characterization of the diatom cyclin-dependent kinase A2 as a mitotic regulator reveals plant-like properties in a non-green lineage [PDF]
, 2015 Background: Cyclin-dependent kinases (CDKs) are crucial regulators of cell cycle progression in eukaryotes. The diatom CDKA2 was originally assigned to the classical A-type CDKs, but its cell cycle phase-specific transcription at the G2-to-M phase ...
Bowler, Chris +4 more
core +2 more sources
Hematology, Transfusion and Cell Therapy, 2021 Introduction: ATLL is a rare and aggressive neoplasm caused by the human T-lymphotropic virus type 1 (HTLV-1). It is estimated that at least 5-10 million people carry HTLV-1 and 2-5% out of them will develop ATLL.
JRA Filho +9 more
doaj +1 more source
Redox Biology, 2022 Endothelial dysfunction is the initial process of atherosclerosis. Heat shock protein 90 (Hsp90), as a molecular chaperone, plays a crucial role in various cardiovascular diseases. Hsp90 function is regulated by S-nitrosylation (SNO).
Shuang Zhao +20 more
doaj +1 more source
Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery
Journal of Hematology & Oncology, 2018 Heat shock protein 90 (Hsp90) is a critical molecular chaperone protein that regulates the folding, maturation, and stability of a wide variety of proteins.
Ting Li +3 more
doaj +1 more source
Generation and Characterization of a Tissue-Specific Centrosome Indicator Mouse Line. [PDF]
, 2016 Centrosomes are major microtubule organizing centers (MTOCs) that play an important role in chromosome segregation during cell division. Centrosomes provide a stable anchor for microtubules, constituting the centers of the spindle poles in mitotic cells,
Chen, Ju +2 more
core +2 more sources
A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells. [PDF]
, 2015 Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors.
Bucko, Paula +8 more
core +1 more source
Temperature stress promotes cell division arrest in Xanthomonas citri subsp. citri
MicrobiologyOpen, 2016 Citrus canker is an economically important disease that affects orange production in some of the most important producing areas around the world. It represents a great threat to the Brazilian and North American citriculture, particularly to the states of
Júlia A. P. Sumares +6 more
doaj +1 more source
The Toxoplasma gondii active serine hydrolase 4 regulates parasite division and intravacuolar parasite architecture [PDF]
, 2018 Hydrolase are enzymes that regulate diverse biological processes, including posttranslational protein modifications. Recent work identified four active serine hydrolases (ASHs) in Toxoplasma gondii as candidate depalmitoylases. However, only TgPPT1 (ASH1)
Amara, Neri +7 more
core +2 more sources
Thyroid status modulates T lymphoma growth via cell cycle regulatory proteins and angiogenesis [PDF]
, 2014 We have shown in vitro that thyroid hormones (THs) regulate the balance between proliferation and apoptosis of T lymphoma cells. The effects of THs on tumor development have been studied, but the results are still controversial.
Barreiro Arcos, María Laura +10 more
core +1 more source