Epigenetic reshaping through damage: promoting cell fate transition by BrdU and IdU incorporation
Cell & BioscienceBackground Thymidine analogs have long been recognized for their ability to randomly incorporate into DNA. However, the precise mechanisms through which thymidine analogs facilitate cell fate transition remains unclear.
Chuang Li +7 more
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Lineages of the Cardiac Conduction System
Journal of Cardiovascular Development and Disease, 2017 The cardiac conduction system (CCS) initiates and coordinately propagates the electrical impulse to orchestrate the heartbeat. It consists of a set of interconnected components with shared properties.
Rajiv Mohan +2 more
doaj +1 more source
The Organization and Cell-lineage of the Ascidian Egg . By Professor E. G. Conklin, Journal of the Academy of Natural Sciences of Philadelphia, Second Series, Volume XIII., Part I., 1905. [PDF]
, 1906 C. M. Child
openalex +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra +17 more
wiley +1 more source
Reconstructing Cell Lineage Trees from Phenotypic Features with Metric Learning [PDF]
arXivHow a single fertilized cell gives rise to a complex array of specialized cell types in development is a central question in biology. The cells grow, divide, and acquire differentiated characteristics through poorly understood molecular processes. A key approach to studying developmental processes is to infer the tree graph of cell lineage division and
arxiv
MITOCHONDRIAL GENETIC ANALYSIS BY ZYGOTE CELL LINEAGES IN SACCHAROMYCES CEREVISIAE [PDF]
, 1973 D. Wilkie, David Y. Thomas
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Compound Heterozygous MRPS14 Variants Associated With Leigh Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT MRPS14 (uS14m) is a nuclear‐encoded ribosomal protein important for mitochondria‐specific translation. To date, only a single individual with a recessive MRPS14‐related disorder (also known as COXPD38) has been reported. We report an additional subject possessing novel compound heterozygous MRPS14 variants (p.Asp37Asn, p.Asn60Asp). The subject
Maria Gabriela Otero +15 more
wiley +1 more source
Efficient Algorithms for Moral Lineage Tracing [PDF]
arXiv, 2017 Lineage tracing, the joint segmentation and tracking of living cells as they move and divide in a sequence of light microscopy images, is a challenging task. Jug et al. have proposed a mathematical abstraction of this task, the moral lineage tracing problem (MLTP), whose feasible solutions define both a segmentation of every image and a lineage forest ...
arxiv
Slow intermixing of cells during Xenopus embryogenesis contributes to the consistency of the blastomere fate map [PDF]
, 1989 The relatively consistent fates of the blastomeres of the frog embryo could result from (i) predetermination of the blastomeres or (ii) reproducible morphogenetic cell movements. In some species, the mixing of the cells during development provides a test
Fraser, Scott E., Wetts, Richard
core
Dissecting endothelial cell heterogeneity with new tools
Cell RegenerationThe formation of a blood vessel network is crucial for organ development and regeneration. Over the past three decades, the central molecular mechanisms governing blood vessel growth have been extensively studied.
Jing Zhong +6 more
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