Results 311 to 320 of about 11,198,861 (420)

Plasticity of CD4+ T cell lineage differentiation.

Immunity, 2009
Liang Zhou, M. Chong, D. Littman
semanticscholar   +1 more source

SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway

Advanced Science, EarlyView.
Structural maintenance of chromosome protein 4 (SMC4) has been implicated in prostate cancer metastasis. Knockdown of SMC4 in RM1‐LM cells significantly attenuates proliferation, migration, and lung metastasis in vivo. Furthermore, SMC4 interacts with GLUT1 (Slc2a1), thereby enhancing glycolysis, ATP production, and activation of the Rheb/mTOR pathway.
Wei Zhang, Siyuan Qin, Xiaokang Li, Ming Chang, Tianzi Wei, Xin Huang, Haibo Tong, Xia Guo, Yi Lu, Jian Zhang   +9 more
wiley   +1 more source

Control of Intestinal Stemness and Cell Lineage by Histone Variant H2A.Z Isoforms. [PDF]

Mol Cell Biol
Rispal J, Rives C, Jouffret V, Leoni C, Dubois L, Chevillard-Briet M, Trouche D, Escaffit F.   +7 more
europepmc   +1 more source

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

Scuphr: A probabilistic framework for cell lineage tree reconstruction. [PDF]

PLoS Comput Biol
Koptagel H, Jun SH, Hård J, Lagergren J.   +3 more
europepmc   +1 more source

Hosts and Commensal Bacteria Synergistically Antagonize Opportunistic Pathogens at the Single‐Cell Resolution

Advanced Science, EarlyView.
In the tripartite‐species model, Drosophila larvae stimulate lactate production through excreting digestion enzymes. S. marcescens population senses a cue of lactate and tends to diverge into virulent and reduced virulence subclusters with remarkable heterogeneity to metabolize carbon metabolism and counter colonization resistance, giving a fitness ...
Sheng Zhang, Ziguang Wang, Anqi Liu, Jinshu Li, Jingjing Zhuang, Xiaowen Ji, Paul I. Mulama, Maoye Li, Haiqun Cao, Eng‐King Tan, Wei Liu   +10 more
wiley   +1 more source

New generalized metric based on branch length distance to compare B cell lineage trees. [PDF]

Algorithms Mol Biol
Farnia M, Tahiri N.
europepmc   +1 more source

3D‐Printed Titanium Trabecular Scaffolds with Sustained Release of Hypoxia‐Induced Exosomes for Dual‐Mimetic Bone Regeneration

Advanced Science, EarlyView.
This study presents 3D‐printed Ti‐6Al‐4V trabecular scaffolds combined with hypoxia‐induced exosomes encapsulated in PEGDA/GelMA microspheres for sustained release. The scaffolds mimic the structure of natural bone, while the exosome delivery system enhances osteogenesis and angiogenesis, significantly promoting bone regeneration and offering a ...
Lincong Luo, Weihan Zheng, Jiaying Li, Tingting Chen, Wanting Xue, Tao Lin, Mingrui Liu, Zi Yan, Jiaxin Yang, Jiamin Li, Jiahao Pu, Yaobin Wu, Konghe Hu, Shiyu Li, Wenhua Huang   +14 more
wiley   +1 more source

Transcriptome-wide analysis reveals potential roles of CFD and ANGPTL4 in fibroblasts regulating B cell lineage for extracellular matrix-driven clustering and novel avenues for immunotherapy in breast cancer. [PDF]

Mol Med
Wang H, Zhu YN, Zhang S, Liu K, Huang R, Li Z, Mei L, Li Y.   +7 more
europepmc   +1 more source

Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell

Cell, 2001
D. Krause, N. Theise, M. Collector, O. Henegariu, Sonya J. Hwang, Rebekah Gardner, S. Neutzel, S. Sharkis   +7 more
semanticscholar   +1 more source