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Chimaeras and Cell Lineage in Development
Nature, 1972CHIMAERAS (or “allophenic individuals”) let us see the pedigree of cells. For instance, a blastocyst compounded from a black-coated-mouse embryo and a white-coated-mouse embryo may develop into a striped or piebald adult mouse1. In other adult tissues, other markers (such as isozymes) reveal a similar conglomerate of two cell types2.
Lewis Wolpert +2 more
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The role of cell lineage in development
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1985Studies of the role of cell lineage in development began in the latter part of the 19th century, fell into decline in the early part of the 20th, and were revived about 20 years ago. This recent revival was accompanied by the introduction of new and powerful analytical techniques.
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The Lineages of Neuroglial Cells
The Neuroscientist, 1996The study of neuroglial cell lineages in the CNS identifies the time in development, when astrocytes and oligodendrocytes diverge from a common precursor cell. Recent studies using retroviral tracing show that the lineages for astrocytes and oligodendrocytes begin to diverge as early as embryonic day 13 (E13) in the cerebellum and as early as E15 in ...
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Stem cells of the melanocyte lineage
Cancer Biomarkers, 2007Melanocytes are pigment-producing cells responsible for coloration of skin and hair. Studies using mouse models have allowed identification of putative melanocyte stem cells within the hair follicle and understanding of hair graying caused by abnormal melanocyte stem cell maintenance. The malignant transformation of melanocytes results in melanoma, the
Kristina Buac, William J. Pavan
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Forcing cells to change lineages
Nature, 2009The ability to produce stem cells by induced pluripotency (iPS reprogramming) has rekindled an interest in earlier studies showing that transcription factors can directly convert specialized cells from one lineage to another. Lineage reprogramming has become a powerful tool to study cell fate choice during differentiation, akin to inducing mutations ...
Thomas Graf, Tariq Enver
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Cell lineage and segmentation in the leech
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1985Segments in the leech arise by the proliferation of longitudinally arrayed bandlets of blast cells derived from ten identifiable embryonic stem cells, two M, two N, four O /P and two Q teloblasts. In each bandlet, older blast cells lie ahead of those born later.
Marty Shankland, David A. Weisblat
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The simplicity of metazoan cell lineages
Nature, 2005Developmental processes are thought to be highly complex, but there have been few attempts to measure and compare such complexity across different groups of organisms. Here we introduce a measure of biological complexity based on the similarity between developmental and computer programs.
Hans-Peter Meinzer +11 more
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The lineage decisions of helper T cells
Nature Reviews Immunology, 2002After encountering antigen, helper T (T(H)) cells undergo differentiation to effector cells, which can secrete high levels of interferon-gamma, interleukin-4 (IL-4), IL-10 and other immunomodulators. How T(H) cells acquire, and remember, new patterns of gene expression is an area of intensive investigation.
Kenneth M. Murphy, Steven L. Reiner
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Cell lineage in molluscan development
Microscopy Research and Technique, 1992AbstractCell lineage specification in molluscs is brought about by two mechanisms: the segregation of morphogenetic plasms and inductive cell interactions. The evidence for the existence of morphogenetic plasms is largely circumstantial, but in one species, Bithynia, such a plasm has been identified in the polar lobe that forms at first cleavage ...
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