Results 11 to 20 of about 12,335,534 (353)
Frontiers in Cell and Developmental Biology, 2021 The origin of multicellular life from unicellular beings is an epochal step in the evolution of eukaryotes. There are several factors influencing cell fate choices during differentiation and morphogenesis of an organism. Genetic make-up of two cells that
Ranjani Dhakshinamoorthy +1 more
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Trafficking and cell migration [PDF]
Traffic, 2009 The migration of single cells and epithelial sheets is of great importance for gastrulation and organ formation in developing embryos and, if misregulated, can have dire consequences e.g. during cancer metastasis. A keystone of cell migration is the regulation of adhesive contacts, which are dynamically assembled and disassembled via endocytosis. Here,
Ulrich, F., Heisenberg, C.
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Frontiers in Microbiology, 2022 The C-terminus of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein E contains a PBM (PDZ-binding motif) targeting PDZ (PSD-95/Dlg/ZO-1) domains, which is identical to the PBM of SARS-CoV.
Yanlei Zhu +9 more
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Guiding Neuronal Cell Migrations [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Neuronal migration is, along with axon guidance, one of the fundamental mechanisms underlying the wiring of the brain. As other organs, the nervous system has acquired the ability to grow both in size and complexity by using migration as a strategy to position cell types from different origins into specific coordinates, allowing for the generation of ...
Marín Parra, Óscar +3 more
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, 2004 Cell migration is crucial to the life of unicellular and multicellular organisms. Unicellular organisms migrate to find food and avoid predators; this migration can occur by swimming through a fluid, which is achieved by flagellar or ciliary beating (exemplified by E. coli or Paramecium, respectively), or crawling along a surface (as in amoebae).
J. Victor Small, Emmanuel Vignal
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eLife, 2021 Physiological and pathological morphogenetic events involve a wide array of collective movements, suggesting that multicellular arrangements confer biochemical and biomechanical properties contributing to tissue-scale organization.
Yelena Y Bernadskaya +4 more
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Regulation of P53 signaling in breast cancer by the E3 ubiquitin ligase RNF187
Cell Death and Disease, 2022 The tumor suppressor P53 plays critical role in preventing cancer. P53 is rarely mutated and remains functional in luminal-type breast cancer(1).
Xin Li +13 more
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Blood Advances, 2017 : CD34 is routinely used to identify and isolate human hematopoietic stem/progenitor cells (HSPCs) for use clinically in bone marrow transplantation, but its function on these cells remains elusive.
Dina B. AbuSamra +8 more
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Spectrin binding motifs regulate Scribble cortical dynamics and polarity function
eLife, 2015 The tumor suppressor protein Scribble (SCRIB) plays an evolutionary conserved role in cell polarity. Despite being central for its function, the molecular basis of SCRIB recruitment and stabilization at the cell cortex is poorly understood.
Batiste Boëda +1 more
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Physical Models of Collective Cell Migration [PDF]
Annual Review of Condensed Matter Physics, 2019 Collective cell migration is a key driver of embryonic development, wound healing, and some types of cancer invasion. Here, we provide a physical perspective of the mechanisms underlying collective cell migration. We begin with a catalog of the cell–cell
Ricard Alert, X. Trepat
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