Results 11 to 20 of about 52,621 (199)
Genome Organization in and around the Nucleolus
Cells, 2019 The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis takes place, and forms around the nucleolar organizer regions (NORs) that comprise ribosomal RNA (rRNA) genes.
Cristiana Bersaglieri, Raffaella Santoro
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Initial genomics of the human nucleolus. [PDF]
PLoS Genetics, 2010 We report for the first time the genomics of a nuclear compartment of the eukaryotic cell. 454 sequencing and microarray analysis revealed the pattern of nucleolus-associated chromatin domains (NADs) in the linear human genome and identified different ...
Attila Németh +9 more
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Therapeutic Approaches Targeting Nucleolus in Cancer
Cells, 2019 The nucleolus is a distinct sub-cellular compartment structure in the nucleus. First observed more than 200 years ago, the nucleolus is detectable by microscopy in eukaryotic cells and visible during the interphase as a sub-nuclear structure immersed in ...
Pietro Carotenuto +4 more
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Ultrastructural cytochemistry of the mammalian cell nucleolus. [PDF]
Journal of Histochemistry & Cytochemistry, 1990 In the present review on the organization of the mammalian cell nucleolus, we report and discuss data obtained during the past 10 years by means of cytochemical and immunocytochemical ultrastructural techniques. Particular emphasis is placed on the following topics: location of the nucleolus organizer regions in interphasic nucleolar components ...
M, Derenzini, M, Thiry, G, Goessens
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The Nucleolus and Parachromatin of the Ascites Tumor Cell [PDF]
The Journal of Cell Biology, 1957 1. A method is described for distinguishing the ribonucleoproteins of the nucleolus and parachromatin of ascitic tumor cells of the mouse. 2. In these cells the transfer of ribonucleoprotein from the nucleus to the cytoplasm can occur in two ways.
Robert Love, R Love
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Long Noncoding RNAs and Stress Response in the Nucleolus
Cells, 2019 Long noncoding RNAs (lncRNAs) perform diverse functions in the regulation of cellular processes. Here we consider a variety of lncRNAs found in the ribosome production center, the nucleolus, and focus on their role in the response to environmental ...
Sergei A. Pirogov +2 more
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Single-cell laser emitting cytometry for label-free nucleolus fingerprinting [PDF]
Nature CommunicationsThe nucleolus, a recognized biomolecular condensate, serves as the hub for ribosome biogenesis within the cell nucleus. Its quantity and morphology are discernible indicators of cellular functional states.
Guocheng Fang +9 more
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ULTRASTRUCTURE OF THE NUCLEOLUS DURING THE CHINESE HAMSTER CELL CYCLE [PDF]
The Journal of Cell Biology, 1971 Changes in the structure of the nucleolus during the cell cycle of the Chinese hamster cell in vitro were studied. Quantitative electron microscopic techniques were used to establish the size and volume changes in nucleolar structures. In mitosis, nucleolar remnants, "persistent nucleoli," consisting predominantly of ribosome-like granular material ...
J S, Noel +3 more
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Nucleolus: the fascinating nuclear body [PDF]
Histochemistry and Cell Biology, 2007 International audienceNucleoli are the prominent contrasted structures of the cell nucleus. In the nucleolus, ribosomal RNAs are synthesized, processed and assembled with ribosomal proteins.
Valentina Sirri +2 more
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A mammalian model reveals inorganic polyphosphate channeling into the nucleolus and induction of a hyper-condensate state [PDF]
Cell Reports: MethodsSummary: Inorganic polyphosphate (polyP) is a ubiquitous polymer that controls fundamental processes. To overcome the absence of a genetically tractable mammalian model, we developed an inducible mammalian cell line expressing Escherichia coli ...
Filipy Borghi +4 more
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