Cell Reports, 2016 The nucleolus is the site of rRNA gene transcription, rRNA processing, and ribosome biogenesis. However, the nucleolus also plays additional roles in the cell. We isolated nucleoli using fluorescence-activated cell sorting (FACS) and identified nucleolus-
Frédéric Pontvianne +11 more
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Yeast nuclear envelope subdomains with distinct abilities to resist membrane expansion [PDF]
, 2006 Peer ...
Cohen-Fix, Orna +5 more
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The Cell’s Nucleolus: an Emerging Target for Chemotherapeutic Intervention [PDF]
ChemMedChem, 2013 AbstractThe transient nucleolus plays a central role in the up‐regulated synthesis of ribosomal RNA (rRNA) to sustain ribosome biogenesis, a hallmark of aberrant cell growth. This function, in conjunction with its unique pathohistological features in malignant cells and its ability to mediate apoptosis, renders this sub‐nuclear structure a potential ...
Amanda J, Pickard, Ulrich, Bierbach
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Nucleolar asymmetry and the importance of septin integrity upon cell cycle arrest. [PDF]
PLoS ONE, 2017 Cell cycle arrest can be imposed by inactivating the anaphase promoting complex (APC). In S. cerevisiae this arrest has been reported to stabilize a metaphase-like intermediate in which the nuclear envelope spans the bud neck, while chromatin repeatedly ...
Urvashi Rai, Fadi Najm, Alan M Tartakoff
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Regulation and Roles of the Nucleolus in Embryonic Stem Cells: From Ribosome Biogenesis to Genome Organization [PDF]
, 2020 The nucleolus is the largest compartment of the eukaryotic cell's nucleus. It acts as a ribosome factory, thereby sustaining the translation machinery. The nucleolus is also the subnuclear compartment with the highest transcriptional activity in the cell,
Gupta, Shivani +1 more
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The Multiple Functions of the Nucleolus in Plant Development, Disease and Stress Responses
Frontiers in Plant Science, 2018 The nucleolus is the most conspicuous domain in the eukaryotic cell nucleus, whose main function is ribosomal RNA (rRNA) synthesis and ribosome biogenesis.
Natalia O. Kalinina +5 more
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Nucleolar localization of the ErbB3 receptor as a new target in glioblastoma
BMC Molecular and Cell Biology, 2022 Background The nucleolus is a subnuclear, non-membrane bound domain that is the hub of ribosome biogenesis and a critical regulator of cell homeostasis. Rapid growth and division of cells in tumors are correlated with intensive nucleolar metabolism as a ...
Marzia Tagliaferro +8 more
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The nucleolus, an ally, and an enemy of cancer cells [PDF]
Histochemistry and Cell Biology, 2018 The rates of ribosome production by a nucleolus and of protein biosynthesis by ribosomes are tightly correlated with the rate of cell growth and proliferation. All these processes must be matched and appropriately regulated to provide optimal cell functioning. Deregulation of certain factors, including oncogenes, controlling these processes, especially
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Cic1p/Nsa3p is required for synthesis and nuclear export of 60S ribosomal subunits [PDF]
, 2003 Cic1p/Nsa3p was previously reported to be associated with the 26S proteasome and required for the degradation of specific substrates, but was also shown to be associated with early pre-60S particles and to be localized to the nucleolus.
Tollervey, D +7 more
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Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery [PDF]
, 2014 Copyright @ 2014 Booth et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.When the nucleolus ...
Elizabeth Petfalski +36 more
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