Results 31 to 40 of about 4,939,783 (282)

The Cell’s Nucleolus: an Emerging Target for Chemotherapeutic Intervention [PDF]

ChemMedChem, 2013
AbstractThe transient nucleolus plays a central role in the up‐regulated synthesis of ribosomal RNA (rRNA) to sustain ribosome biogenesis, a hallmark of aberrant cell growth. This function, in conjunction with its unique pathohistological features in malignant cells and its ability to mediate apoptosis, renders this sub‐nuclear structure a potential ...
Amanda J, Pickard, Ulrich, Bierbach
openaire   +2 more sources

The nucleolus: a raft adrift in the nuclear sea or the keystone in nuclear structure?

Biomolecular Concepts, 2013
The nucleolus is a prominent nuclear structure that is the site of ribosomal RNA (rRNA) transcription, and hence ribosome biogenesis. Cellular demand for ribosomes, and hence rRNA, is tightly linked to cell growth and the rRNA makes up the majority of ...
O’Sullivan Justin M., Pai Dave A., Cridge Andrew G., Engelke David R., Ganley Austen R.D.   +4 more
doaj   +1 more source

High-Resolution Microscopy to Learn the Nuclear Organization of the Living Yeast Cells

Stem Cells International, 2021
The spatial organization of the nucleus is a key determinant in all genome activities. However, the accurate measurement of the nuclear organization is still technically challenging.
Renjie Wang, Aiwen Huang, Yan Wang, Pengxin Mei, He Zhu, Qianqian Chen, Sankui Xu   +6 more
doaj   +1 more source

RNA Relocation and Persistence of Nucleolus-Like Bodies at Mitosis in Benzo[a]Pyrene-Transformed Human Breast Epithelial Cells after Microcell-Mediated Transfer of Chromosomes 11 and 17

Analytical Cellular Pathology, 2001
RNA relocation and the incidence of nucleolus‐like bodies accumulated during mitosis were studied cytochemically in benzo[a]pyrene (BP)‐transformed human breast epithelial MCF‐10F cells after microcell‐mediated transfer of normal chromosomes 11 and 17 ...
Maria Luiza S. Mello, Mohamed H. Lareef, Benedicto C. Vidal, Jose Russo   +3 more
doaj   +1 more source

Nucleolar protein trafficking in response to HIV-1 Tat: rewiring the nucleolus. [PDF]

PLoS ONE, 2012
The trans-activator Tat protein is a viral regulatory protein essential for HIV-1 replication. Tat trafficks to the nucleoplasm and the nucleolus. The nucleolus, a highly dynamic and structured membrane-less sub-nuclear compartment, is the site of rRNA ...
Mohamed Ali Jarboui, Carlo Bidoia, Elena Woods, Barbara Roe, Kieran Wynne, Giuliano Elia, William W Hall, Virginie W Gautier   +7 more
doaj   +1 more source

Rlp7p is associated with 60S preribosomes, restricted to the granular component of the nucleolus, and required for pre-rRNA processing [PDF]

, 2002
Many analyses have examined subnucleolar structures in eukaryotic cells, but the relationship between morphological structures, pre-rRNA processing, and ribosomal particle assembly has remained unclear.
Tollervey, D, Hurt, E, Pierre-Emmanuel Gleizes, Elisabeth Petfalski, Ed Hurt, Olivier Gadal, David Tollervey, Gleizes, P E, Strauss, D, Gas, N, Daniela Strauss, Gadal, O, Petfalski, E, Nicole Gas   +13 more
core   +1 more source

The enteropathogenic E. coli effector EspF targets and disrupts the nucleolus by a process regulated by mitochondrial dysfunction.

PLoS Pathogens, 2010
The nucleolus is a multifunctional structure within the nucleus of eukaryotic cells and is the primary site of ribosome biogenesis. Almost all viruses target and disrupt the nucleolus--a feature exclusive to this pathogen group. Here, using a combination
Paul Dean, Jon A Scott, Andrew A Knox, Sabine Quitard, Nicholas J Watkins, Brendan Kenny   +5 more
doaj   +1 more source

Studies on the relation between heme and nucleic acid syntheses in erythroid cell. 3. Nucleolus of erythroblast, changes in relation with cell specialization [PDF]

, 1969
The disappearance of nucleolus has been traced in the rat erythroid cells in relation with the cell specialization under varying conditions, i. e. in anemia with or without treatment by bromouracil and aminopterin.
Shigehisa, Morio
core   +1 more source

Ultrastructural cytochemistry of the mammalian cell nucleolus. [PDF]

Journal of Histochemistry & Cytochemistry, 1990
In the present review on the organization of the mammalian cell nucleolus, we report and discuss data obtained during the past 10 years by means of cytochemical and immunocytochemical ultrastructural techniques. Particular emphasis is placed on the following topics: location of the nucleolus organizer regions in interphasic nucleolar components ...
M, Derenzini, M, Thiry, G, Goessens
openaire   +2 more sources

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source