Results 41 to 50 of about 52,621 (199)

The nucleolus: a raft adrift in the nuclear sea or the keystone in nuclear structure?

Biomolecular Concepts, 2013
The nucleolus is a prominent nuclear structure that is the site of ribosomal RNA (rRNA) transcription, and hence ribosome biogenesis. Cellular demand for ribosomes, and hence rRNA, is tightly linked to cell growth and the rRNA makes up the majority of ...
O’Sullivan Justin M., Pai Dave A., Cridge Andrew G., Engelke David R., Ganley Austen R.D.   +4 more
doaj   +1 more source

In vivo analysis of NHPX reveals a novel nucleolar localization pathway involving a transient accumulation in splicing speckles [PDF]

, 2002
The NHPX protein is a nucleolar factor that binds directly to a conserved RNA target sequence found in nucleolar box C/D snoRNAs and in U4 snRNA. Using enhanced yellow fluorescent protein (EYFP)– and enhanced cyan fluorescent protein–NHPX fusions, we ...
Leung, Anthony K. L., Angus I. Lamond, Anthony K.L. Leung, Lamond, Angus I.; id_orcid   +3 more
core   +1 more source

High-Resolution Microscopy to Learn the Nuclear Organization of the Living Yeast Cells

Stem Cells International, 2021
The spatial organization of the nucleus is a key determinant in all genome activities. However, the accurate measurement of the nuclear organization is still technically challenging.
Renjie Wang, Aiwen Huang, Yan Wang, Pengxin Mei, He Zhu, Qianqian Chen, Sankui Xu   +6 more
doaj   +1 more source

RNA Relocation and Persistence of Nucleolus-Like Bodies at Mitosis in Benzo[a]Pyrene-Transformed Human Breast Epithelial Cells after Microcell-Mediated Transfer of Chromosomes 11 and 17

Analytical Cellular Pathology, 2001
RNA relocation and the incidence of nucleolus‐like bodies accumulated during mitosis were studied cytochemically in benzo[a]pyrene (BP)‐transformed human breast epithelial MCF‐10F cells after microcell‐mediated transfer of normal chromosomes 11 and 17 ...
Maria Luiza S. Mello, Mohamed H. Lareef, Benedicto C. Vidal, Jose Russo   +3 more
doaj   +1 more source

M148R and M149R are two virulence factors for myxoma virus pathogenesis in the European rabbit [PDF]

, 2009
Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus).
Camus-Bouclainville, Christelle, Sophie Blanié, Blanié, Sophie, Christelle Camus-Bouclainville, Mortier, Jérémy, Stéphane Bertagnoli, Mortier, J, Maxence Delverdier, Bertagnoli, Stéphane, Jérémy Mortier, Delverdier, Maxence   +10 more
core   +1 more source

Nucleolar protein trafficking in response to HIV-1 Tat: rewiring the nucleolus. [PDF]

PLoS ONE, 2012
The trans-activator Tat protein is a viral regulatory protein essential for HIV-1 replication. Tat trafficks to the nucleoplasm and the nucleolus. The nucleolus, a highly dynamic and structured membrane-less sub-nuclear compartment, is the site of rRNA ...
Mohamed Ali Jarboui, Carlo Bidoia, Elena Woods, Barbara Roe, Kieran Wynne, Giuliano Elia, William W Hall, Virginie W Gautier   +7 more
doaj   +1 more source

The enteropathogenic E. coli effector EspF targets and disrupts the nucleolus by a process regulated by mitochondrial dysfunction.

PLoS Pathogens, 2010
The nucleolus is a multifunctional structure within the nucleus of eukaryotic cells and is the primary site of ribosome biogenesis. Almost all viruses target and disrupt the nucleolus--a feature exclusive to this pathogen group. Here, using a combination
Paul Dean, Jon A Scott, Andrew A Knox, Sabine Quitard, Nicholas J Watkins, Brendan Kenny   +5 more
doaj   +1 more source

Studies on the relation between heme and nucleic acid syntheses in erythroid cell. 3. Nucleolus of erythroblast, changes in relation with cell specialization

, 1969
The disappearance of nucleolus has been traced in the rat erythroid cells in relation with the cell specialization under varying conditions, i. e. in anemia with or without treatment by bromouracil and aminopterin.
Shigehisa, Morio
core   +1 more source

NIR is a nucleolar RNA-binding protein that is involved in cell proliferation [PDF]

Archives of Biological Sciences, 2013
A novel inhibitor of histone acetyltransferase repressor (NIR) is a histone acetylation inhibitor that associates with p53, p63 and histone complexes. Staining with anti-NIR antibodies revealed that the protein is localized at the nucleolus.
Kang Min Kook, Han Seung Jin
doaj   +1 more source

Single-molecule dynamics suggest that ribosomes assemble at sites of translation in Bacillus subtilis

Frontiers in Microbiology, 2022
Eukaryotic cells transcribe ribosomal RNA and largely assemble ribosomes in a structure called the nucleolus, where chromosomal regions containing rRNA operons are clustered.
Joshua Stoll, Victor Zegarra, Gert Bange, Peter L. Graumann   +3 more
doaj   +1 more source