Results 31 to 40 of about 61,199 (301)

Cell-penetrating peptide exploited syndecans

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2010
Cell-penetrating peptides (CPPs) are short peptides capable of translocating across the plasma membrane of live cells and transporting conjugated compounds intracellularly. Fifteen years after discovering the first model cationic CPPs, penetratin and TAT, CPP internalization is still challenging many questions.
Letoha, Tarnas, Keller-Pinter, Aniko, Kusz, Erzsebet, Kolozsi, Csongor, Bozso, Zsolt, Toth, Gabor, Vizler, Csaba, Olah, Zoltan, Szilak, Laszlo   +8 more
openaire   +3 more sources

Matrix stiffness affects endocytic uptake of MK2-inhibitor peptides. [PDF]

, 2013
In this study, the role of substrate stiffness on the endocytic uptake of a cell-penetrating peptide was investigated. The cell-penetrating peptide, an inhibitor of mitogen-activated protein kinase activated protein kinase II (MK2), enters a primary ...
Brugnano, Jamie L, Panitch, Alyssa
core   +10 more sources

Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide. [PDF]

, 2016
Malignant gliomas have poor prognosis and urgently require new therapies. Activating Transcription Factor 5 (ATF5) is highly expressed in gliomas, and interference with its expression/function precipitates targeted glioma cell apoptosis in vitro and in ...
Angelastro, James, Arias, Angelo, Cates, Charles, Cayanan, Geraldine, Fung, Jennifer, Greene, Lloyd, Karpel-Massler, Georg, Lamé, Michael, Nakayama Wong, Lynn, Rowland, Douglas, Sidorov, Maxim, Siegelin, Markus   +11 more
core   +2 more sources

Hybrid peptides inspired by the RWQWRWQWR sequence inhibit cervical cancer cells growth in vitro [PDF]

Exploration of Drug Science
Aim: The aim of this research was to generate new peptide molecules with cytotoxic activity against cervical cancer that can become effective in mitigating the impact of the disease and preventing its progression.
Natalia Ardila-Chantré, Claudia Marcela Parra-Giraldo, Yerly Vargas-Casanova, Andrea Carolina Barragán-Cardenas, Ricardo Fierro-Medina, Zuly Jenny Rivera-Monroy, Jhon Erick Rivera-Monroy, Javier Eduardo García-Castañeda   +7 more
doaj   +1 more source

Cleavage of the vaspin N-terminus releases cell-penetrating peptides that affect early stages of adipogenesis and inhibit lipolysis in mature adipocytes

Adipocyte, 2021
Vaspin expression and function is related to metabolic disorders and comorbidities of obesity. In various cellular and animal models of obesity, diabetes and atherosclerosis vaspin has shown beneficial, protective and/or compensatory action.
Catherine A. Tindall, Estelle Erkner, Jan Stichel, Annette G. Beck-Sickinger, Anne Hoffmann, Juliane Weiner, John T. Heiker   +6 more
doaj   +1 more source

Beyond the discovered peptides by Viktor Mutt – a contribution [PDF]

Proceedings of the Estonian Academy of Sciences
A summary of the results obtained in the collaboration between the laboratory of Prof. Viktor Mutt at Karolinska Institutet and our laboratory at Stockholm University, headed by Prof. Tamas Bartfai, is given.
Ülo Langel
doaj   +1 more source

Characterisation of cell‐penetrating peptide‐mediated peptide delivery [PDF]

British Journal of Pharmacology, 2005
Cell‐penetrating peptides such as antennapedia, TAT, transportan and polyarginine have been extensively employed for in vitro and in vivo delivery of biologically active peptides. However, little is known of the relative efficacy, toxicity and uptake mechanism of individual protein transduction domain–peptide conjugates, factors that will be critical
Jones, Simon W., Christison, Richard, Bundell, Ken, Voyce, Catherine J., Brockbank, Sarah M V, Newham, Peter, Lindsay, Mark A.   +6 more
openaire   +2 more sources

Do Cell-Penetrating Peptides Actually “Penetrate” Cellular Membranes? [PDF]

Molecular Therapy, 2012
Cell-penetrating peptides (CPPs), also referred to as peptide transduction domains (PTDs), are polypeptide domains that can enter many, if not most, cell types. CPP/PTDs mediate transduction into cells of a wide range of cargos that otherwise lack bioavailability, such as peptides, proteins, antisense oligonucleotides, and small interfering RNAs.
Palm-Apergi, Caroline, Lönn, Peter, Dowdy, Steven F   +2 more
openaire   +2 more sources

Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]

, 2013
Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P., Cooper, A., Curreli, F., Debnath, A.K., Freed, E.O., Lee, S., Mehta, M., Mercredi, P.Y., Scacalossi, D., Summers, M.F., Tong, X., Waheed, A.A., Zhang, H.   +12 more
core   +2 more sources

Ligands for oral delivery of peptides across the blood-brain-barrier

Acta Materia Medica, 2022
Peptides are short chains of amino acids linked by peptide bonds. Many peptides and proteins are limited by their poor enzymatic stability and permeability across the intestinal epithelial membranes and/or blood-brain barrier (BBB).
Murad Al Gailani, Mengyang Liu, Jingyuan Wen   +2 more
doaj   +1 more source