Mechanobiology of the nucleus during the G2-M transition
NucleusCellular behavior is continuously influenced by mechanical forces. These forces span the cytoskeleton and reach the nucleus, where they trigger mechanotransduction pathways that regulate downstream biochemical events.
Joana T. Lima, Jorge G. Ferreira
doaj +1 more source
Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome
Nature Communications, 2020 While biallelic mutations of the SLC26A4 gene cause non-syndromic hearing loss with enlarged vestibular aqueducts or Pendred syndrome, a considerable number of patients carry mono-allelic mutations.
Mengnan Li +21 more
doaj +1 more source
The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis [PDF]
, 2013 The spatial and temporal control of polarity is fundamental to the survival of all organisms. Cells define their polarity using highly conserved mechanisms that frequently rely upon the action of small GTPases, such as Ras and Cdc42.
A Merla +58 more
core +3 more sources
Unified quantitative characterization of epithelial tissue development
eLife, 2015 Understanding the mechanisms regulating development requires a quantitative characterization of cell divisions, rearrangements, cell size and shape changes, and apoptoses.
Boris Guirao +8 more
doaj +1 more source
A safeguard mechanism regulates Rho GTPases to coordinate cytokinesis with the establishment of cell polarity. [PDF]
PLoS Biology, 2013 The spatiotemporal control of cell polarity is crucial for the development of multicellular organisms and for reliable polarity switches during cell cycle progression in unicellular systems.
Franz Meitinger +5 more
doaj +1 more source
Combined effect of cell geometry and polarity domains determines the orientation of unequal division
eLife, 2021 Cell division orientation is thought to result from a competition between cell geometry and polarity domains controlling the position of the mitotic spindle during mitosis.
Benoit G Godard +3 more
doaj +1 more source
A screen for round egg mutants in Drosophila identifies tricornered, furry, and misshapen as regulators of egg chamber elongation. [PDF]
, 2012 The elongation of tissues and organs during embryonic development results from the coordinate polarization of cell behaviors with respect to the elongation axis.
Bilder, David +4 more
core +2 more sources
Where does asymmetry come from?:Illustrating principles of polarity and asymmetry establishment in Drosophila neuroblasts [PDF]
, 2020 Asymmetric cell division (ACD) is the fundamental process through which one cell divides into two cells with different fates. In animals, it is crucial for the generation of cell-type diversity and for stem cells, which use ACD both to self-renew and ...
Januschke, Jens, Loyer, Nicolas
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms? [PDF]
Open Biology, 2013 Spatio-temporal coordination of events during cell division is crucial for animal development. In recent years, emerging data have strengthened the notion that tight coupling of cell cycle progression and cell polarity in dividing cells is crucial for ...
Anna Noatynska +3 more
doaj +1 more source