Results 1 to 10 of about 13,797,858 (403)

Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice

Biology of Sex Differences, 2023
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in Western countries, evolving into metabolic dysfunction-associated steatohepatitis (MASH) with a sexual dimorphism. Fertile women exhibit lower MASLD risk than men,
Carlos Cuño-Gómiz, Estefanía de Gregorio, Anna Tutusaus, Patricia Rider, Nuria Andrés-Sánchez, Anna Colell, Albert Morales, Montserrat Marí   +7 more
doaj   +1 more source

Antioxidants Threaten Multikinase Inhibitor Efficacy against Liver Cancer by Blocking Mitochondrial Reactive Oxygen Species

Antioxidants, 2021
Sorafenib and regorafenib, multikinase inhibitors (MKIs) used as standard chemotherapeutic agents for hepatocellular carcinoma (HCC), generate reactive oxygen species (ROS) during cancer treatment.
Blanca Cucarull, Anna Tutusaus, Tania Hernáez-Alsina, Pablo García de Frutos, María Reig, Anna Colell, Montserrat Marí, Albert Morales   +7 more
doaj   +1 more source

CELL PROLIFERATION

Cell Proliferation, 2006
Abstract Cell proliferation is the earliest step in the protracted process of mammalian brain development. Various genetic and environmental factors modulate the pace of cell proliferation and the number and type of cells produced.
Masaru, Iwai, Masatsugu, Horiuchi
  +5 more sources

Correlating Cell Behavior with Tissue Topology in Embryonic Epithelia [PDF]

, 2011
Measurements on embryonic epithelial tissues in a diverse range of organisms have shown that the statistics of cell neighbor numbers are universal in tissues where cell proliferation is the primary cell activity.
Chuai, Manli, Newman, Timothy J., Sandersius, Sebastian A., Weijer, Cornelis J.   +3 more
core   +13 more sources

NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation

Nature Communications, 2021
Mitotic spindle assembly is required for proper cell division, but many underlying mechanisms remain unclear. Here, the authors show that NuMa undergoes liquid-liquid phase separation, condensing on spindle poles during mitotic entry and enriching ...
Mengjie Sun, Mingkang Jia, He Ren, Biying Yang, Wangfei Chi, Guangwei Xin, Qing Jiang, Chuanmao Zhang   +7 more
doaj   +1 more source

Role of Oxidative Stress in Liver Disorders

Livers, 2022
Oxygen is vital for life as it is required for many different enzymatic reactions involved in intermediate metabolism and xenobiotic biotransformation.
Laura Conde de la Rosa, Leire Goicoechea, Sandra Torres, Carmen Garcia-Ruiz, José C. Fernandez-Checa   +4 more
doaj   +1 more source

The role of cellular fibronectin in the interaction of human endothelial cells with polymers [PDF]

, 1993
During in-vitro adhesion, spreading and proliferation of human endothelial cells (HEC) on tissue culture polystyrene (TCPS), cellular fibronectin is deposited onto the surface of TCPS in spite of the fact that relatively large amounts of proteins have ...
Aken, W.G. van, Bantjes, A., Beugeling, T., Dekker, A., Feijen, J., Mourik, J.A. van, Poot, A., Spijkers, J.   +7 more
core   +12 more sources

Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by intermittent anti-PI3Kα/β/δ treatment

Nature Communications, 2022
Limited response to immune checkpoint inhibitors has been reported in patients with castration-resistant prostate cancer. Here the authors show that intermittent, but not continuous, treatment with an anti-PI3Kα/β/δ-inhibitor promotes anti-tumor immunity
Zhi Qi, Zihan Xu, Liuzhen Zhang, Yongkang Zou, Jinping Li, Wenyu Yan, Cheng Li, Ningshu Liu, Hong Wu   +8 more
doaj   +1 more source

Transcription shapes DNA replication initiation to preserve genome integrity

Genome Biology, 2021
Background Early DNA replication occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question of how early DNA replication coordinates with transcription to avoid collisions and DNA damage.
Yang Liu, Chen Ai, Tingting Gan, Jinchun Wu, Yongpeng Jiang, Xuhao Liu, Rusen Lu, Ning Gao, Qing Li, Xiong Ji, Jiazhi Hu   +10 more
doaj   +1 more source

Skin Cell Proliferation Stimulated by Microneedles [PDF]

, 2012
A classical wound may be defined as a disruption of tissue integrity. Wounds, caused by trauma from accidents or surgery, that close via secondary intention rely on the biological phases of healing, i.e., hemostasis, inflammation, proliferation, and ...
Kloth, Luther C., Liebl, Horst
core   +2 more sources