Results 1 to 10 of about 12,836,766 (354)

Mitochondrial fragmentation enables localized signaling required for cell repair. [PDF]

J Cell Biol, 2020
Mitochondria exist as a dynamic network, and their fragmentation is associated with cell death. We found that mitochondria near the cell membrane injury site rapidly fragment and enable local signaling for repair.
Horn A, Raavicharla S, Shah S, Cox D, Jaiswal JK.   +4 more
europepmc   +2 more sources

3D Bioprinting of Novel Biocompatible Scaffolds for Endothelial Cell Repair. [PDF]

Polymers (Basel), 2019
The aim of this study was to develop and evaluate an optimized 3D bioprinting technology in order to fabricate novel scaffolds for the application of endothelial cell repair.
Wu Y, Heikal L, Ferns G, Ghezzi P, Nokhodchi A, Maniruzzaman M.   +5 more
europepmc   +2 more sources

Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis. [PDF]

Nat Aging, 2021
Childs BG, Zhang C, Shuja F, Sturmlechner I, Trewartha S, Fierro Velasco R, Baker D, Li H, van Deursen JM.   +8 more
europepmc   +2 more sources

In Vitro Veritas: From 2D Cultures to Organ-on-a-Chip Models to Study Immunogenic Cell Death in the Tumor Microenvironment

Cells, 2022
Immunogenic cell death (ICD) is a functionally unique form of cell death that promotes a T-cell-dependent anti-tumor immune response specific to antigens originating from dying cancer cells.
Dmitri V. Krysko, Robin Demuynck, Iuliia Efimova, Faye Naessens, Olga Krysko, Elena Catanzaro   +5 more
doaj   +1 more source

HS3ST2 expression induces the cell autonomous aggregation of tau

Scientific Reports, 2022
Heparan sulfates have long been known to intracellularly accumulate in Alzheimer’s disease neurons, where they colocalize with neurofibrillary tangles made of abnormally phosphorylated and aggregated tau protein.
M. B. Huynh, N. Rebergue, H. Merrick, W. Gomez-Henao, E. Jospin, D. S. F. Biard, D. Papy-Garcia   +6 more
doaj   +1 more source

Ferroptosis: friend or foe in cancer immunotherapy?

OncoImmunology, 2023
Ferroptosis has gained interest due to it immunogenicity and the higher sensitivity of cancer cells to it. However, it was recently shown that ferroptosis in tumor-associated neutrophils leads to immunosuppression and negatively impacts therapy. Here, we
Robin Demuynck, Iuliia Efimova, Elena Catanzaro, Dmitri V Krysko   +3 more
doaj   +1 more source

Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke.

Immunity, 2021
The precise mechanisms underlying the beneficial effects of regulatory T (Treg) cells on long-term tissue repair remain elusive. Here, using single-cell RNA sequencing and flow cytometry, we found that Treg cells infiltrated the brain 1 to 5 weeks after ...
Ligen Shi, Zeyu Sun, W. Su, Fei Xu, Di Xie, Qingxiu Zhang, Xuejiao Dai, Kartik Iyer, T. K. Hitchens, L. Foley, Sicheng Li, D. Stolz, Kong Chen, Ying Ding, A. Thomson, R. Leak, Jun Chen, Xiaoming Hu   +17 more
semanticscholar   +1 more source

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. [PDF]

, 2020
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex multi-cellular organ that intimately links with the cardiovascular system to accomplish gas exchange.
Basil, Maria C, Chapman, Hal A, Engler, Anna E, Guo, Minzhe, Herriges, Michael J, Kathiriya, Jaymin J, Katzen, Jeremy, Kotton, Darrell N, Morrisey, Edward E, Rock, Jason R, Snoeck, Hans-Willem, Vunjak-Novakovic, Gordana, Whitsett, Jeffrey A, Windmueller, Rebecca, Ysasi, Alexandra B, Zacharias, William J   +15 more
core   +2 more sources

Sulfated Undaria pinnatifida Polysaccharide Promotes Endocytosis of Nano-Calcium Oxalate Dihydrate by Repairing Subcellular Organelles in HK-2 Cells

Antioxidants, 2023
The clinical manifestation of primary hyperoxaluria includes hyperoxaluria and recurrent urinary calculi. In this study, an oxidative damage model was constructed based on oxalate damage to the human renal proximal tubular epithelial cells (HK-2), and a ...
Xue-Wu Chen, Yu-Yun Zheng, Jian-Ming Ouyang   +2 more
doaj   +1 more source

Heparan sulfate functions are altered in the osteoarthritic cartilage

Arthritis Research & Therapy, 2020
Background Heparan sulfate (HS) proteoglycans (PG) may be found at the chondrocyte surface and in the pericellular cartilage matrix, and are involved in cell-cell and cell-matrix interactions.
Sara Shamdani, Sandrine Chantepie, Camille Flageollet, Nadia Henni-Chebra, Yohann Jouan, Florent Eymard, Eric Hay, Martine Cohen-Solal, Dulce Papy-Garcia, Xavier Chevalier, Patricia Albanese   +10 more
doaj   +1 more source