The rate of X-ray-induced DNA double-strand break repair in the embryonic mouse brain is unaff ected by exposure to 50 Hz magnetic fi elds [PDF]
, 2015 Following in utero exposure to low dose radiation (10 – 200 mGy), we recently observed a linear induction of DNA double-strand breaks (DSB) and activation of apoptosis in the embryonic neuronal stem/progenitor cell compartment.
Ahlbom IC +30 more
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c-Abl Kinase Is Required for Satellite Cell Function Through Pax7 Regulation
Frontiers in Cell and Developmental Biology, 2021 Satellite cells (SCs) are tissue-specific stem cells responsible for adult skeletal muscle regeneration and maintenance. SCs function is critically dependent on two families of transcription factors: the paired box (Pax) involved in specification and ...
Fabián Montecino +6 more
doaj +1 more source
NaNog: A pluripotency homeobox (master) molecule. [PDF]
, 2015 One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed necessary , then at a specified time can differentiate into any type of cell. This fundamental process
Aguib, YE +4 more
core +1 more source
Heart repair and stem cells [PDF]
The Journal of Physiology, 2006 Of the medical conditions currently being discussed in the context of possible treatments based on cell transplantation therapy, few have received more attention than the heart. Much focus has been on the potential application of bone marrow‐derived cell preparations, which have already been introduced into double‐blind, placebo‐controlled clinical ...
Linda W, van Laake +3 more
openaire +2 more sources
Multispectral imaging flow cytometry reveals distinct frequencies of γ-H2AX foci induction in DNA double strand break repair defective human cell lines [PDF]
, 2011 Copyright @ 2012 International Society for Advancement of Cytometry. The article can be accessed from the links below.This article has been made available through the Brunel Open Access Publishing Fund.The measurement of γ-H2AX foci induction in cells ...
Bottley, G +6 more
core +1 more source
ATM in focus:a damage sensor and cancer target [PDF]
, 2012 The ability of a cell to conserve and maintain its native DNA sequence is fundamental for the survival and normal functioning of the whole organism and protection from cancer development.
Khalil, Hilal S. +2 more
core +4 more sources
Bone repair and stem cells [PDF]
Current Opinion in Genetics & Development, 2016 Bones are an important component of vertebrates; they grow explosively in early life and maintain their strength throughout life. Bones also possess amazing capabilities to repair-the bone is like new without a scar after complete repair. In recent years, a substantial progress has been made in our understanding on mammalian bone stem cells.
Noriaki, Ono, Henry M, Kronenberg
openaire +2 more sources
Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures [PDF]
, 2013 The repair of articular cartilage is challenging due to the sparse native cell population combined with the avascular and aneural nature of the tissue. In recent years cartilage tissue engineering has shown great promise.
Blitterswijk, C.A. van +4 more
core +3 more sources
Transplantation of Bioreactor-Produced Neural Stem Cells into the Rodent Brain
Cell Transplantation, 2006 The development of new cell replacement strategies using neural stem cells (NSC) may provide an alternative and unlimited cell source for clinical neural transplantation in neurodegenerative diseases such as Parkinson's and Huntington's disease.
M. Mcleod Ph.D. +6 more
doaj +1 more source
A 3D Cell Death Assay to Quantitatively Determine Ferroptosis in Spheroids
Cells, 2020 The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening.
Robin Demuynck +4 more
doaj +1 more source