Results 151 to 160 of about 488,024 (316)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A versatile CMOS building block for fully analogically-programmable VLSI cellular neural networks
, 1994 The design of a new CMOS building block to be used for analogically programming the control and the feedback operators of cellular neural networks is reported.
Setti G., Piovaccari A.
core +1 more source
Beyond natural biology: rewiring cellular networks to study innate immunity. [PDF]
Curr Opin Immunol, 2023 Landau LM, Kagan JC.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
On the emergence and evolution of artificial cell signaling networks [PDF]
, 2007 This PhD project is concerned with the evolution of Cell Signaling Networks (CSNs) in silico. CSNs are complex biochemical networks responsible for the coordination of cellular activities.
Decraene, James
core
A geocast architecture for mobile cellular networks
, 2000 In this paper, we address the geocasting problem for cellular mobile networks. The crucial components to support geocasting services are, the geolocation mechanism, dispersion of the geolocation information, and geocast message routing and delivery.
Ali N. Akansu +8 more
core +1 more source
Kinase Mobility Shift Assay (KiMSA) for Assessing Protein Kinase A Activity
Bio-ProtocolThe cAMP-dependent protein kinase (PKA) is one of the most extensively distributed kinases among intracellular signal cascades, with a pivotal role in the regulation of various processes, including the capacitation of sperm cells. Traditional assessments
Analia Novero +8 more
doaj +1 more source
Interference mitigation in intentional jammers aided non-uniform heterogeneous cellular networks. [PDF]
PLoS One, 2023 Ghonaim SM +7 more
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source