Results 161 to 170 of about 459,720 (267)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Targeting AXL cellular networks in kidney fibrosis. [PDF]

Front Immunol
Grøndal SM, Blø M, Nilsson LIH, Rayford AJ, Jackson A, Gausdal G, Lorens JB.   +6 more
europepmc   +1 more source

A Dynamic Algorithm for Interference Management in D2D-Enabled Heterogeneous Cellular Networks: Modeling and Analysis. [PDF]

Sensors (Basel), 2022
Kamruzzaman M, Sarkar NI, Gutierrez J.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Spatial Cellular Networks from omics data with SpaCeNet. [PDF]

Genome Res
Schrod S, Lück N, Lohmayer R, Solbrig S, Völkl D, Wipfler T, Shutta KH, Ben Guebila M, Schäfer A, Beißbarth T, Zacharias HU, Oefner PJ, Quackenbush J, Altenbuchinger M.   +13 more
europepmc   +1 more source

SOX9 Protein in Pancreatic Cancer Regulates Multiple Cellular Networks in a Cell-Specific Manner. [PDF]

Biomedicines, 2022
Kopantzev E, Kondratyeva L, Kopantseva M, Kashkin K, Gnatenko D, Grigorieva E, Alekseenko I, Safina D, Chernov I.   +8 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Trioxane-based MS-cleavable cross-linking mass spectrometry for profiling multimeric interactions of cellular networks. [PDF]

Nat Commun
Yu C, Novitsky E, Balasubramani SG, Wang X, Shen X, Yang Q, Rychnovsky S, Echeverria I, Huang L.   +8 more
europepmc   +1 more source

Location-Privacy Leakage and Integrated Solutions for 5G Cellular Networks and Beyond. [PDF]

Sensors (Basel), 2021
Tomasin S, Centenaro M, Seco-Granados G, Roth S, Sezgin A.   +4 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source