Results 11 to 20 of about 223,630 (253)

CD8+CD122+ T-cells: a newly emerging regulator with central memory cell phenotypes [PDF]

Frontiers in Immunology, 2015
CD8+CD122+ T-cells have been traditionally described as antigen-specific memory T-cells that respond to previously encountered antigens more quickly and vigorously than their naïve counterparts.
Dacan eChen, Dacan eChen, Junfeng eLiu, Junfeng eLiu, Golay eNie, Zhenhua eDai, Zhenhua eDai   +6 more
doaj   +3 more sources

Smad4 represses the generation of memory-precursor effector T cells but is required for the differentiation of central memory T cells. [PDF]

Cell Death Dis, 2015
AbstractThe transcriptional regulation underlying the differentiation of CD8+ effector and memory T cells remains elusive. Here, we show that 18-month-old mice lacking the transcription factor Smad4 (homolog 4 of mothers against decapentaplegic, Drosophila), a key intracellular signaling effector for the TGF-β superfamily, in T cells exhibited lower ...
Cao J, Zhang X, Wang Q, Qiu G, Hou C, Wang J, Cheng Q, Lan Y, Han H, Shen H, Zhang Y, Yang X, Shen B, Zhang J.   +13 more
europepmc   +4 more sources

Distinct CD4−CD8− (Double-Negative) Memory T-Cell Subpopulations Are Associated With Indeterminate and Cardiac Clinical Forms of Chagas Disease

Frontiers in Immunology, 2021
CD4−CD8− (double-negative, DN) T cells are critical orchestrators of the cytokine network associated with the pathogenic inflammatory response in one of the deadliest cardiomyopathies known, Chagas heart disease, which is caused by Trypanosoma cruzi ...
Livia Silva Araújo Passos, Livia Silva Araújo Passos, Carolina Cattoni Koh, Luísa Mourão Dias Magalhães, Luísa Mourão Dias Magalhães, Maria do Carmo Pereira Nunes, Kenneth John Gollob, Kenneth John Gollob, Walderez Ornelas Dutra, Walderez Ornelas Dutra, Walderez Ornelas Dutra   +10 more
doaj   +1 more source

Runx3-overexpression cooperates with ex vivo AKT inhibition to generate receptor-engineered T cells with better persistence, tumor-residency, and antitumor ability

Journal for ImmunoTherapy of Cancer, 2023
Background Solid tumors pose unique roadblocks to treatment with chimeric antigen receptor (CAR) T cells, including limited T-cell persistence, inefficient tumor infiltration, and an immunosuppressive tumor microenvironment. To date, attempts to overcome
Qi Zhang, Jiangchao Wu, Tingbo Liang, Xueli Bai, Xun Wang, Jianpeng Sheng, Junlei Zhang, Jianghui Tang, Jinyuan Song, Yongtao Ji   +9 more
doaj   +1 more source

Extensive Replicative Capacity of Human Central Memory T Cells [PDF]

The Journal of Immunology, 2004
Abstract To characterize the replicative capacity of human central memory (TCM) CD4 T cells, we have developed a defined culture system optimized for the ex vivo expansion of Ag-specific CD4+ T cells. Artificial APCs (aAPCs) consisting of magnetic beads coated with Abs to HLA class II and a costimulatory Ab to CD28 were prepared; peptide-
Marcela V, Maus, Birgit, Kovacs, William W, Kwok, Gerald T, Nepom, Katia, Schlienger, James L, Riley, David, Allman, Terri H, Finkel, Carl H, June   +8 more
openaire   +2 more sources

Concurrent generation of effector and central memory CD8 T cells during vaccinia virus infection. [PDF]

PLoS ONE, 2008
It is generally thought that during the contraction phase of an acute anti-viral T cell reponse, the effector T cells that escape activation-induced cell death eventually differentiate into central memory T cells over the next several weeks.
Amale Laouar, Monika Manocha, Viraga Haridas, N Manjunath   +3 more
doaj   +1 more source

Central memory CD4+ T cells dominate the normal cerebrospinal fluid [PDF]

Cytometry Part B: Clinical Cytometry, 2010
To use cerebrospinal fluid (CSF) immune phenotyping as a diagnostic and research tool, we have set out to establish reference values of white blood cell (WBC) subsets in CSF.We assessed the absolute numbers and percentages of WBC subsets by 6-color flow cytometry in paired CSF and blood samples of 84 individuals without neurological disease who ...
Graaf, Marieke, Sillevis Smitt, Peter, Luitwieler, RL, van Velzen, C, Broek, Patricia, Kraan, Juliette, Gratama, Jan willem   +6 more
openaire   +3 more sources

Central and effector memory T cells in peripheral blood of patients with interstitial pneumonia: preliminary clues from a COVID-19 study

Respiratory Research, 2022
Background SARS-CoV-2 pre-existing T-cell immune reactivity can be present in some people. A general perturbation of the main peripheral lymphocyte subsets has been described in severe COVID-19 patients, but very few studies assessed the general memory T-
Makhabbat Bekbossynova, Lyudmila Akhmaltdinova, Kuanysh Dossybayeva, Ainur Tauekelova, Zauresh Smagulova, Tatyana Tsechoeva, Gulsimzhan Turebayeva, Aliya Sailybayeva, Zhanar Kalila, Tahmina Mirashirova, Timur Muratov, Dimitri Poddighe   +11 more
doaj   +1 more source

Cutting Edge: Central Memory CD8 T Cells in Aged Mice Are Virtual Memory Cells [PDF]

The Journal of Immunology, 2013
Abstract The number of memory phenotype CD8 T cells increases dramatically with aging in both humans and mice. However, the mechanism for this is unknown. The prevailing hypothesis is that memory T cells accumulate with aging as a result of lifelong antigenic stimulation. However, data supporting this supposition are lacking.
Bo-Chin, Chiu, Brian E, Martin, Valerie R, Stolberg, Stephen W, Chensue   +3 more
openaire   +2 more sources

A CD45RO+ stem cell memory T cell population intermediate to canonical stem cell memory and central memory T cells in human cancer. [PDF]

, 2022
Abstract T memory stem cells (Tscm) are integral for effective immunotherapy and antitumor responses, but little is known about Tscm immunobiology in solid human tumors. Here we identify self-renewing and multipotent Tscm tumor-infiltrating lymphocytes (TILs) in human cancer and present a novel Tscm subset which expresses CD45RO, is derived ...
Daniel Powell, Monika Eiva, Erica Brown, Veethika Pandey, Alexander Benton, Stacy Thomas, Wenzhao Meng, Aaron Rosenfeld, Eline Luning Prak   +8 more
openaire   +1 more source