Results 21 to 30 of about 223,630 (253)

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates [PDF]

Journal of Clinical Investigation, 2008
The adoptive transfer of antigen-specific T cells that have been expanded ex vivo is being actively pursued to treat infections and malignancy in humans. The T cell populations that are available for adoptive immunotherapy include both effector memory and central memory cells, and these differ in phenotype, function, and homing.
Carolina, Berger, Michael C, Jensen, Peter M, Lansdorp, Mike, Gough, Carole, Elliott, Stanley R, Riddell   +5 more
openaire   +2 more sources

BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals.

PLoS ONE, 2021
BCG vaccination is known to induce innate immune memory, which confers protection against heterologous infections. However, the effect of BCG vaccination on the conventional adaptive immune cells subsets is not well characterized.
Nathella Pavan Kumar, Chandrasekaran Padmapriyadarsini, Anuradha Rajamanickam, Perumal Kannabiran Bhavani, Arul Nancy, Bharathi Jayadeepa, Nandhini Selvaraj, Dinesh Asokan, Rachel Mariam Renji, Vijayalakshmi Venkataramani, Srikanth Tripathy, Subash Babu   +11 more
doaj   +2 more sources

Molecular Signatures Distinguish Human Central Memory from Effector Memory CD8 T Cell Subsets [PDF]

The Journal of Immunology, 2005
Abstract Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naive central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells using gene expression microarrays and phospho-protein-specific intracellular flow cytometry.
Willinger, Tim, Freeman, Tom, Hasegawa, Hitoshi, McMichael, Andrew J, Callan, Margaret F C   +4 more
openaire   +3 more sources

CMV‐specific central memory T cells reside in bone marrow [PDF]

European Journal of Immunology, 2007
AbstractCMV‐specific CD8+ T cell responses in peripheral blood (PB) are characterized by a preponderance of effector and effector memory T cells. CMV‐specific central memory T cells (TCM), which are considered crucial in maintaining long‐term immunity, are rarely detectable in PB.
Anne, Letsch, Maren, Knoedler, Il-Kang, Na, Florian, Kern, Anne-Marie, Asemissen, Ulrich, Keilholz, Michael, Loesch, Eckhard, Thiel, Hans-Dieter, Volk, Carmen, Scheibenbogen   +9 more
openaire   +2 more sources

Age related human T cell subset evolution and senescence

Immunity & Ageing, 2019
T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects.
Mingde Li, Danlin Yao, Xiangbo Zeng, Dimitri Kasakovski, Yikai Zhang, Shaohua Chen, Xianfeng Zha, Yangqiu Li, Ling Xu   +8 more
doaj   +1 more source

Immunotherapeutic Potential of T Memory Stem Cells

Frontiers in Oncology, 2021
Memory T cells include T memory stem cells (TSCM) and central memory T cells (TCM). Compared with effector memory T cells (TEM) and effector T cells (TEFF), they have better durability and anti-tumor immunity. Recent studies have shown that although TSCM
Yujie Li, Dengqiang Wu, Xuejia Yang, Sufang Zhou, Sufang Zhou   +4 more
doaj   +1 more source

Unidirectional development of CD8⁺ central memory T cells into protective Listeria‐specific effector memory T cells [PDF]

European Journal of Immunology, 2006
AbstractThree distinct subsets of antigen‐experienced CD8+ T cells have been identified so far: short‐living effector T cells (TEC) and two long‐living subsets, described as central (TCM) and effector memory (TEM) T cells. The lineage relationships of these subpopulations as well as their involvement in protection have not yet been conclusively ...
Katharina M, Huster, Martina, Koffler, Christian, Stemberger, Matthias, Schiemann, Hermann, Wagner, Dirk H, Busch   +5 more
openaire   +2 more sources

Rapid Transduction and Expansion of Transduced T Cells with Maintenance of Central Memory Populations

Molecular Therapy: Methods & Clinical Development, 2020
Chimeric antigen receptor (CAR)-T cells show great promise in treating cancers and viral infections. However, most protocols developed to expand T cells require relatively long periods of time in culture, potentially leading to progression toward ...
Mary S. Pampusch, Kumudhini Preethi Haran, Geoffrey T. Hart, Eva G. Rakasz, Aaron K. Rendahl, Edward A. Berger, Elizabeth Connick, Pamela J. Skinner   +7 more
doaj   +1 more source

Identification of immune cell infiltration and effective biomarkers of polycystic ovary syndrome by bioinformatics analysis

BMC Pregnancy and Childbirth, 2023
Background Patients with polycystic ovary syndrome (PCOS) exhibit a chronic inflammatory state, which is often accompanied by immune, endocrine, and metabolic disorders.
Mengge Gao, Xiaohua Liu, Mengxuan Du, Heng Gu, Hang Xu, Xingming Zhong   +5 more
doaj   +1 more source

Bystander Central Memory but Not Effector Memory CD8+ T Cells Suppress Allograft Rejection [PDF]

The Journal of Immunology, 2008
Abstract Memory T cells respond faster and more vigorously than their naive counterparts and are critical for adaptive immunity. However, it is unknown whether and how memory T cells react in the face of irrelevant Ags. It is generally accepted that bystander memory T cells are neutral in immune responsiveness.
Ni, Wan, Hehua, Dai, Tao, Wang, Yolonda, Moore, Xin Xiao, Zheng, Zhenhua, Dai   +5 more
openaire   +2 more sources