Results 31 to 40 of about 223,630 (253)

High CCR5 density on central memory CD4+ T cells in acute HIV-1 infection is mostly associated with rapid disease progression. [PDF]

PLoS ONE, 2012
CD4+ central memory T cells play a critical role in the pathogenesis of simian immunodeficiency virus disease, and the CCR5 density on the surface of CD4 T cells is an important factor in human immunodeficiency virus (HIV)-1 disease progression.
Xue Yang, Yan-mei Jiao, Rui Wang, Yun-xia Ji, Hong-wei Zhang, Yong-hong Zhang, De-xi Chen, Tong Zhang, Hao Wu   +8 more
doaj   +1 more source

A Pool of Central Memory-Like CD4 T Cells Contains Effector Memory Precursors [PDF]

The Journal of Immunology, 2003
AbstractThe L51S mutation in the D10.G4.1 TCR α-chain reduces the affinity of the TCR to its ligand by affecting the interactions among the TCR, the β-chain of I-Ak, and the bound peptide. We show that this mutation drives the generation of a pool of memory CD44highCD62LnegCD45RBneg CD4 TCR transgenic T cells.
J Magarian, Blander, Derek B, Sant'Angelo, Daniela, Metz, Sang-Won, Kim, Richard A, Flavell, Kim, Bottomly, Charles A, Janeway   +6 more
openaire   +2 more sources

Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia

Journal of Hematology & Oncology, 2018
Stem cell memory T (TSCM) and central memory T (TCM) cells can rapidly differentiate into effector memory (TEM) and terminal effector (TEF) T cells, and have the most potential for immunotherapy. In this study, we found that the frequency of TSCM and TCM
Ling Xu, Danlin Yao, Jiaxiong Tan, Zifan He, Zhi Yu, Jie Chen, Gengxin Luo, Chunli Wang, Fenfang Zhou, Xianfeng Zha, Shaohua Chen, Yangqiu Li   +11 more
doaj   +1 more source

Hoxb4 overexpression in CD4 memory phenotype T cells increases the central memory population upon homeostatic proliferation. [PDF]

PLoS ONE, 2013
Memory T cell populations allow a rapid immune response to pathogens that have been previously encountered and thus form the basis of success in vaccinations.
Héloïse Frison, Gloria Giono, Paméla Thébault, Marilaine Fournier, Nathalie Labrecque, Janet J Bijl   +5 more
doaj   +1 more source

Comparison of the Development of SARS-Coronavirus-2-Specific Cellular Immunity, and Central Memory CD4+ T-Cell Responses Following Infection versus Vaccination

Vaccines, 2021
Memory T-cell responses following infection with coronaviruses are reportedly long-lived and provide long-term protection against severe disease. Whether vaccination induces similar long-lived responses is not yet clear since, to date, there are limited ...
Kevin M. Dennehy, Eva Löll, Christine Dhillon, Johanna-Maria Classen, Tobias D. Warm, Lukas Schuierer, Alexander Hyhlik-Dürr, Christoph Römmele, Yvonne Gosslau, Elisabeth Kling, Reinhard Hoffmann   +10 more
doaj   +1 more source

Recombinant BCG expressing the LTAK63 adjuvant increased memory T cells and induced long-lasting protection against Mycobacterium tuberculosis challenge in mice

Frontiers in Immunology, 2023
Vaccine-induced protection against Mycobacterium tuberculosis (Mtb) is usually ascribed to the induction of Th1, Th17, and CD8+ T cells. However, protective immune responses should also involve other immune cell subsets, such as memory T cells.
Lázaro Moreira Marques-Neto, Monalisa Martins Trentini, Alex Issamu Kanno, Dunia Rodriguez, Luciana Cezar de Cerqueira Leite   +4 more
doaj   +1 more source

Central memory self/tumor-reactive CD8 ⁺ T cells confer superior antitumor immunity compared with effector memory T cells [PDF]

Proceedings of the National Academy of Sciences, 2005
Central memory CD8 + T cells (T CM ) and effector memory CD8 + T cells (T EM ) are found in humans and mice; however, their relative contributions to host immunity have only recently been examined in vivo .
Christopher A, Klebanoff, Luca, Gattinoni, Parizad, Torabi-Parizi, Keith, Kerstann, Adela R, Cardones, Steven E, Finkelstein, Douglas C, Palmer, Paul A, Antony, Sam T, Hwang, Steven A, Rosenberg, Thomas A, Waldmann, Nicholas P, Restifo   +11 more
openaire   +2 more sources

Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis

Journal of Translational Medicine, 2007
Background Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease.
Novitskaya Inna, Khatcherian Artemis, Cardinale Irma, Sullivan-Whalen Mary, Gilleaudeau Patricia, Kikuchi Toyoko, Lee Edmund, Lin Shao-Lee, Chamian Francesca, Wittkowski Knut M, Krueger James G, Lowes Michelle A   +11 more
doaj   +1 more source

Manufacture of Gene-Modified Human T-Cells with a Memory Stem/Central Memory Phenotype [PDF]

Human Gene Therapy Methods, 2014
Advances in genetic engineering have made it possible to generate human T-cell products that carry desired functionalities, such as the ability to recognize cancer cells. The currently used strategies for the generation of gene-modified T-cell products lead to highly differentiated cells within the infusion product, and on the basis of data obtained in
Gomez-Eerland, Raquel, Nuijen, Bastiaan, Heemskerk, Bianca, van Rooij, Nienke, van den Berg, Joost H, Beijnen, Jos H, Uckert, Wolfgang, Kvistborg, Pia, Schumacher, Ton N, Haanen, John B A G, Jorritsma, Annelies   +10 more
openaire   +4 more sources

Role of Immunological Memory Cells as a Therapeutic Target in Multiple Sclerosis

Brain Sciences, 2017
Pharmacological targeting of memory cells is an attractive treatment strategy in various autoimmune diseases, such as psoriasis and rheumatoid arthritis.
Tanima Bose
doaj   +1 more source