Results 221 to 230 of about 429,016 (241)

The Role of Glia Telomere Dysfunction in the Pathogenesis of Central Nervous System Diseases. [PDF]

Mol Neurobiol
Papageorgakopoulou MA, Bania A, Lagogianni IA, Birmpas K, Assimakopoulou M.   +4 more
europepmc   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Current progression in application of extracellular vesicles in central nervous system diseases. [PDF]

Eur J Med Res
Zhang XM, Huang J, Ni XY, Zhu HR, Huang ZX, Ding S, Yang XY, Tan YD, Chen JF, Cai JH.   +9 more
europepmc   +1 more source

Hodgkin's Disease-Related Central Nervous System Angiopathy Presenting as Reversible Posterior Leukoencephalopathy

, 2004
Yusei Miyazaki, Yasutaka Tajima, Kazumasa Sudo, Akihisa Matsumoto, Jun Tashiro, Seiji Kikuchi, Hidenao Sasaki, Kunio Tashiro   +7 more
openalex   +2 more sources

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Progress in the Treatment of Central Nervous System Diseases Based on Nanosized Traditional Chinese Medicine. [PDF]

Adv Sci (Weinh)
Li J, Long Q, Ding H, Wang Y, Luo D, Li Z, Zhang W.   +6 more
europepmc   +1 more source

Wearable Systems of Reconfigurable Microneedle Electrode Array for Subcutaneous Multiplexed Recording of Myoelectric and Electrochemical Signals

Advanced Science, EarlyView.
A reconfigurable microneedle electrode array integrated system is developed for minimally invasive and transdermal monitoring of subcutaneous electromyography, reactive oxygen species, and pH values. By assembling discrete thumbtack‐shaped microneedles into an array, the system enables multi‐parameter detection with single‐microneedle resolution.
Zhengjie Liu, Chuanjie Yao, Xingyuan Xu, Xinshuo Huang, Shuang Huang, Shantao Zheng, Tao Zhang, Yan Li, Fanmao Liu, Yuxiang Wu, Jing Liu, Hui‐jiuan Chen, Xi Xie   +12 more
wiley   +1 more source

Advances in molecular mechanisms and therapeutic strategies for central nervous system diseases based on gut microbiota imbalance. [PDF]

J Adv Res
Tao W, Zhang Y, Wang B, Nie S, Fang L, Xiao J, Wu Y.   +6 more
europepmc   +1 more source

Consequences and Mechanisms of Noise‐Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing

Advanced Science, EarlyView.
Noise‐induced synaptopathy (NIS) is largely reversible due to self‐repair. NIS and noise‐induced hidden hearing loss are two concepts with similarities and differences. The major hearing deficits in NIHHL are temporal processing disorders. The translation of animal data in NIS studies to humans is hindered by many factors.
Hui Wang, Steven J Aiken, Jian Wang
wiley   +1 more source

Does Surgical Treatment for Benign Prostate Enlargement (BPE)-Related Bladder Outlet Obstruction (BOO) Benefit Patients with Central Nervous System Diseases? A Systematic Review. [PDF]

J Clin Med
Charalampous I, Tsikopoulos I, Mitkani C, Samarinas M, Yuan Y, Vouros I, Tsafrakidis P, Anastasios A, Gkotsi A, Sakalis V.   +9 more
europepmc   +1 more source