Results 51 to 60 of about 600,930 (299)
Chinese Journal of Contemporary Neurology and Neurosurgery, 2021 Objective To investigate the clinicopathological features of central nervous system diffuse and multifocal lesions in the cerebral white matter. Methods The clinical and radiological data of 27 cases of diffuse and multifocal lesions in the cerebral ...
FU Yong⁃juan
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Spectrum of acute central nervous system demyelinating diseases [PDF]
Perspectives In Medical Research, 2017 Central nervous system(CNS) demyelinative diseases are mainly Multiple Sclerosis, Acute Disseminated Encephalomyelitis (ADEM), Acute hemorrhagic Leucoencephalitis (AHL). Multiple Sclerosis is the most common.
Bharathkanth Reddy M1 , Ranjith Kumar P2 , P.L John Israel3
doaj
Restorative therapy using microglial depletion and repopulation for central nervous system injuries and diseases [PDF]
, 2022 Weipeng Shi +6 more
openalex +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Microphysiological Systems for Neurodegenerative Diseases in Central Nervous System
Micromachines, 2020 Neurodegenerative diseases are among the most severe problems in aging societies. Various conventional experimental models, including 2D and animal models, have been used to investigate the pathogenesis of (and therapeutic mechanisms for ...
Mihyeon Bae +3 more
doaj +1 more source
A review on recent advances on nobiletin in central and peripheral nervous system diseases [PDF]
, 2023 Yueshan Pang +3 more
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Viral diseases of the central nervous system [PDF]
Current Opinion in Virology, 2015 Virus-induced diseases of the central nervous system (CNS) represent a significant burden to human health worldwide. The complexity of these diseases is influenced by the sheer number of different neurotropic viruses, the diverse routes of CNS entry, viral tropism, and the immune system.
Phillip A, Swanson, Dorian B, McGavern
openaire +2 more sources
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source